Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

• Published in: Journal of biomedical optics Vol. 29; no. 3; p. 037002
• Main Authors: Kline, Olivia, Vishwanath, Karthik, Colbrunn, Boyd, Peachman, Andrew, Zhang, Jing, Vadivelu, Sudhakar
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.03.2024; SPIE
• Subjects: Child; Children; Health aspects; Humans; Hydrocephalus; Pain - complications; Pediatrics; Retrospective Studies; Sensing; Spectrum Analysis; Ventriculoperitoneal Shunt - adverse effects; United States; optical spectroscopy; vascular nociception; tissue optics; visible-near infrared; in vivo
• DOI: 10.1117/1.JBO.29.3.037002
• ISSN: 1083-3668; 1560-2281

Shuntodynia is patient reported pain at the site of the implanted ventriculoperitoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement is a chronic and prevalent standard of care treatment and requires lifetime management. Shuntodynia is a subjective measure of shunt dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in the clinic. Pediatric subjects were recruited for optical sensing during routine clinical follow-up visits, post-VP shunt implantations. Acquired optical signals were translated into skin-hemodynamic signatures and were compared between subjects that reported shuntodynia versus those that did not. Diffuse reflectance spectroscopy (DRS) measurements were collected between 450 and 700 nm using a single-channel fiber-optical probe from ( ) patients. Multiple reflectance spectra were obtained by the attending physician from regions both proximal and distal to the VP shunt sites and from a matched contralateral site for each subject. Acquired reflectance spectra were processed quantitatively into functional tissue optical endpoints. A two-way, repeated measures analysis of variance was used to assess whether and which of the optical variables were statistically separable, across subjects with shuntodynia versus those without. Analyses indicated that intrapatient differences in vascular oxygen saturation measured between shunt sites relative to that obtained at the scar or contralateral sites was significantly lower in the pain group. We also find that the total hemoglobin concentrations at the shunt site were lowest relative to the other sites for subjects reporting pain. These findings suggest that shuntodynia pain arises in the scalp tissue around the implanted shunts and may be caused due to hypoxia and inflammation. Optically derived hemodynamic variables were statistically significantly different in subjects presenting with shuntodynia relative to those without. DRS could provide a viable mode in routine bedside monitoring of subjects with VP shunts for clinical management and assessment of shuntodynia.