Evaluation of urinary N-acetyl cysteinyl allyl isothiocyanate as a biomarker for intake and bioactivity of Brussels sprouts

• Published in: Food and chemical toxicology Vol. 41; no. 12; pp. 1817 - 1825
• Main Authors: Hwang, E.-S, Jeffery, E.H
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2003
• Subjects: Acetylcysteine - metabolism; Allyl isothiocyanate; Animals; Anticarcinogenic Agents - urine; Biomarkers; Brassica - metabolism; Brassica oleracea gemnifera; Brussels sprouts; Cooking; Diet; Dose-Response Relationship, Drug; Eating; Glucosinolates - metabolism; Humans; Isothiocyanates - urine; Male; Mercapturic acid; N-acetyl cysteine; N-acetyl cysteinyl allyl isothiocyanate; NAD(P)H Dehydrogenase (Quinone) - metabolism; Proteins - metabolism; Quinone reductase; Rats; Rats, Inbred F344; Sinigrin; QR; AITC; Quinone reductase; Mercapturic acid; Allyl isothiocyanate; BS; BSA; NAC; β-NADPH; Brussels sprouts; N-acetyl cysteine; Sinigrin; HPLC

Isothiocyanates (ITC), glucosinolate hydrolysis products from Brussels sprouts (BS) and other cruciferous vegetables, are considered to protect the body from cancer by induction of detoxification enzymes such as quinone reductase (QR). Urinary N-acetyl-cysteine ( NAC) conjugates of ITC have been pro...