Myosteatosis, but not Sarcopenia, Predisposes NAFLD Subjects to Early Steatohepatitis and Fibrosis Progression

• Published in: Clinical gastroenterology and hepatology Vol. 21; no. 2; pp. 388 - 397.e10
• Main Authors: Hsieh, Yun-Cheng, Joo, Sae Kyung, Koo, Bo Kyung, Lin, Han-Chieh, Lee, Dong Hyeon, Chang, Mee Soo, Park, Jeong Hwan, So, Young Ho, Kim, Won
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023
• Subjects: Fibrosis; Gastroenterology and Hepatology; Humans; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - complications; Muscle Quality; Myocyte; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - epidemiology; Non-alcoholic Fatty Liver Disease - metabolism; Prospective Studies; Sarcopenia; Sarcopenia - complications; Sarcopenia - epidemiology; Steatosis; NAFLD; VATI; ALT; HR; HU; Myocyte; Muscle Quality; Sarcopenia; HDL; MA; hs-CRP; NAFL; BMI; AST; OR; CI; L3; LSM; IQR; NASH; SMI; Steatosis; CT; HOMA-IR; TE; TG; GGT; high-density lipoprotein; alanine aminotransferase; high-sensitivity C-reactive protein; odds ratio; gamma-glutamyl transferase; nonalcoholic steatohepatitis; homeostasis model assessment of insulin resistance; Hounsfield unit; nonalcoholic fatty liver; body mass index; third lumbar vertebra; nonalcoholic fatty liver disease; transient elastography; interquartile range; skeletal muscle index; computed tomography; liver stiffness measurement; visceral adipose tissue index; triglycerides; aspartate aminotransferase; hazard ratio; confidence interval; muscle attenuation

Sarcopenia and myosteatosis are associated with advanced nonalcoholic fatty liver disease (NAFLD). However, muscle alterations in early stage NAFLD remain unclear. Patients with nonalcoholic fatty liver (NAFL) or early nonalcoholic steatohepatitis (NASH) without significant fibrosis were selected fr...