miRNA-132/212 Gene-Deletion Aggravates the Effect of Oxygen-Glucose Deprivation on Synaptic Functions in the Female Mouse Hippocampus

Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily conserved short-length/noncoding RNA molecules recently implicated in adaptive/maladaptive neuronal responses to ischemia. Previous research...

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Published inCells (Basel, Switzerland) Vol. 10; no. 7; p. 1709
Main Authors Bormann, Daniel, Stojanovic, Tamara, Cicvaric, Ana, Schuld, Gabor J., Cabatic, Maureen, Ankersmit, Hendrik Jan, Monje, Francisco J.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.07.2021
MDPI
Subjects
Acetylcholine receptors (muscarinic)
Acetylcholine receptors (nicotinic)
Alzheimer's disease
Animal cognition
Brain research
Brain slice preparation
Complications
Dentate gyrus
field excitatory postsynaptic potentials (fEPSP)
Gene deletion
Glucose
Hippocampus
Hypoxia
Injuries
Ischemia
MeCP2 protein
Memory
Methyl-CpG binding protein
miRNA
miRNA 132/212
Neurogenesis
Oxygen
oxygen-glucose deprivation (OGD)
Pathophysiology
Physiology
Stroke
Synaptic transmission
United Kingdom > UK
Austria
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Abstract Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily conserved short-length/noncoding RNA molecules recently implicated in adaptive/maladaptive neuronal responses to ischemia. Previous research independently implicated the miRNA-132/212 cluster in cholinergic signaling and synaptic transmission, and in adaptive/protective mechanisms of neuronal responses to hypoxia. However, the putative role of miRNA-132/212 in the response of synaptic transmission to ischemia remained unexplored. Using hippocampal slices from female miRNA-132/212 double-knockout mice in an established electrophysiological model of ischemia, we here describe that miRNA-132/212 gene-deletion aggravated the deleterious effect of repeated oxygen-glucose deprivation insults on synaptic transmission in the dentate gyrus, a brain region crucial for learning and memory functions. We also examined the effect of miRNA-132/212 gene-deletion on the expression of key mediators in cholinergic signaling that are implicated in both adaptive responses to ischemia and hippocampal neural signaling. miRNA-132/212 gene-deletion significantly altered hippocampal AChE and mAChR-M1, but not α7-nAChR or MeCP2 expression. The effects of miRNA-132/212 gene-deletion on hippocampal synaptic transmission and levels of cholinergic-signaling elements suggest the existence of a miRNA-132/212-dependent adaptive mechanism safeguarding the functional integrity of synaptic functions in the acute phase of cerebral ischemia.
AbstractList Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily conserved short-length/noncoding RNA molecules recently implicated in adaptive/maladaptive neuronal responses to ischemia. Previous research independently implicated the miRNA-132/212 cluster in cholinergic signaling and synaptic transmission, and in adaptive/protective mechanisms of neuronal responses to hypoxia. However, the putative role of miRNA-132/212 in the response of synaptic transmission to ischemia remained unexplored. Using hippocampal slices from female miRNA-132/212 double-knockout mice in an established electrophysiological model of ischemia, we here describe that miRNA-132/212 gene-deletion aggravated the deleterious effect of repeated oxygen-glucose deprivation insults on synaptic transmission in the dentate gyrus, a brain region crucial for learning and memory functions. We also examined the effect of miRNA-132/212 gene-deletion on the expression of key mediators in cholinergic signaling that are implicated in both adaptive responses to ischemia and hippocampal neural signaling. miRNA-132/212 gene-deletion significantly altered hippocampal AChE and mAChR-M1, but not α7-nAChR or MeCP2 expression. The effects of miRNA-132/212 gene-deletion on hippocampal synaptic transmission and levels of cholinergic-signaling elements suggest the existence of a miRNA-132/212-dependent adaptive mechanism safeguarding the functional integrity of synaptic functions in the acute phase of cerebral ischemia.
Author Schuld, Gabor J.
Ankersmit, Hendrik Jan
Bormann, Daniel
Stojanovic, Tamara
Cicvaric, Ana
Cabatic, Maureen
Monje, Francisco J.
AuthorAffiliation 4 Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York, NY 10461, USA; ana.cicvaric@einsteinmed.org
1 Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria; n1118880@students.meduniwien.ac.at (D.B.); tamara.stojanovic@meduniwien.ac.at (T.S.); n01629958@students.meduniwien.ac.at (G.J.S.); maureen.cabatic@meduniwien.ac.at (M.C.)
3 Division of Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2 Laboratory for Cardiac and Thoracic Diagnosis, Department of Surgery, Regeneration and Applied Immunology, Medical University of Vienna, Research Laboratories Vienna General Hospital, Waehringer Guertel 18-20, 1090 Vienna, Austria; hendrik.ankersmit@meduniwien.ac.at
5 Aposcience AG, Dresdner Straße 87/A 21, 1200 Vienna, Austria
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– name: 4 Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, New York, NY 10461, USA; ana.cicvaric@einsteinmed.org
– name: 2 Laboratory for Cardiac and Thoracic Diagnosis, Department of Surgery, Regeneration and Applied Immunology, Medical University of Vienna, Research Laboratories Vienna General Hospital, Waehringer Guertel 18-20, 1090 Vienna, Austria; hendrik.ankersmit@meduniwien.ac.at
– name: 1 Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria; n1118880@students.meduniwien.ac.at (D.B.); tamara.stojanovic@meduniwien.ac.at (T.S.); n01629958@students.meduniwien.ac.at (G.J.S.); maureen.cabatic@meduniwien.ac.at (M.C.)
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Snippet Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily...
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StartPage 1709
SubjectTerms Acetylcholine receptors (muscarinic)
Acetylcholine receptors (nicotinic)
Alzheimer's disease
Animal cognition
Brain research
Brain slice preparation
Complications
Dentate gyrus
field excitatory postsynaptic potentials (fEPSP)
Gene deletion
Glucose
Hippocampus
Hypoxia
Injuries
Ischemia
MeCP2 protein
Memory
Methyl-CpG binding protein
miRNA
miRNA 132/212
Neurogenesis
Oxygen
oxygen-glucose deprivation (OGD)
Pathophysiology
Physiology
Stroke
Synaptic transmission
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Title miRNA-132/212 Gene-Deletion Aggravates the Effect of Oxygen-Glucose Deprivation on Synaptic Functions in the Female Mouse Hippocampus
URI https://www.proquest.com/docview/2554474916
https://pubmed.ncbi.nlm.nih.gov/PMC8306255
https://doaj.org/article/503a5d8c8d7c459bb0474eb03cae4515
Volume 10
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