Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders

• Published in: Journal of affective disorders Vol. 215; pp. 118 - 124
• Main Authors: Jiang, Xiaoling, Zhong, Wen, An, Haiyan, Fu, Mingyu, Chen, Yuanyuan, Zhang, Zhenggang, Xiao, Zhongju
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: Acute stress response; Adolescent; Adult; Case-Control Studies; Dehydroepiandrosterone - metabolism; Dehydroepiandrosterone Sulfate - metabolism; Depressive Disorder - complications; Depressive Disorder - metabolism; Depressive disorders; DHEA; DHEA-S; Female; Humans; Hydrocortisone - metabolism; Hypothalamo-Hypophyseal System - metabolism; Male; Pituitary-Adrenal System - metabolism; Psychiatric Status Rating Scales; Psychiatry; Saliva - metabolism; Stress, Psychological - complications; Stress, Psychological - metabolism; Young Adult; DHEA; Acute stress response; DHEA-S; Depressive disorders

In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders....