Mice lacking α1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens

• Published in: Pathology international Vol. 64; no. 5; pp. 199 - 208
• Main Authors: Kashiwazaki, Hiromi, Kakizaki, Masatoshi, Ikehara, Yuzuru, Togayachi, Akira, Narimatsu, Hisashi, Watanabe, Rihito
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.05.2014; John Wiley and Sons Inc
• Subjects: Animals; Brain - pathology; Brain - virology; Cell Count; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - prevention & control; cytokine; Cytokines - metabolism; Disease Models, Animal; Fucosyltransferases - deficiency; Fucosyltransferases - genetics; Fucosyltransferases - physiology; Fut9; Immunity, Innate - genetics; Immunity, Innate - immunology; Immunity, Innate - physiology; Lewis X; Lipopolysaccharides - immunology; MHV; Mice; Mice, Knockout; Mice, Mutant Strains; Murine hepatitis virus - immunology; Murine hepatitis virus - isolation & purification; neuropathogenic virus; Original; Spleen - pathology; Spleen - virology; cytokine; Lewis X; neuropathogenic virus; MHV; Fut9

Carbohydrate structures, including Lewis X (Lex), which is not synthesized in mutant mice that lack α1,3‐fucosyltransferase 9 (Fut9−/−), are involved in cell–cell recognition and inflammation. However, immunological alteration in Fut9−/− mice has not been studied. Thus, the inflammatory response of...