Mycobacterium tuberculosis‐specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease

• Published in: European journal of immunology Vol. 43; no. 6; pp. 1568 - 1577
• Main Authors: Rozot, Virginie, Vigano, Selena, Mazza‐Stalder, Jesica, Idrizi, Elita, Day, Cheryl L., Perreau, Matthieu, Lazor‐Blanchet, Catherine, Petruccioli, Elisa, Hanekom, Willem, Goletti, Delia, Bart, Pierre‐Alexandre, Nicod, Laurent, Pantaleo, Giuseppe, Harari, Alexandre
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.06.2013
• Subjects: Active TB disease; Acute Disease; Antigens, CD - metabolism; CD8-Positive T-Lymphocytes - immunology; Cell Proliferation; Cells, Cultured; Cytokines - metabolism; Cytotoxicity; Functional profile; GPI-Linked Proteins - metabolism; Humans; Immunology; Immunophenotyping; Latent Mtb infection; Latent Tuberculosis - immunology; Lymphocytes; Mtb‐specific CD8+ T cells; Mycobacterium tuberculosis - immunology; Programmed Cell Death 1 Receptor - metabolism; Receptors, Immunologic - metabolism; Signaling Lymphocytic Activation Molecule Family; T cell receptors; T-Lymphocyte Subsets - immunology; Tuberculosis; Tuberculosis, Pulmonary - immunology

Protective immunity to Mycobacterium tuberculosis (Mtb) remains poorly understood and the role of Mtb‐specific CD8+ T cells is controversial. Here we performed a broad phenotypic and functional characterization of Mtb‐specific CD8+ T cells in 326 subjects with latent Mtb infection (LTBI) or active T...