Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 1; pp. 148 - 154
• Main Authors: Amrein, Karin, Amrein, Steven, Drexler, Camilla, Dimai, Hans Peter, Dobnig, Harald, Pfeifer, Klaus, Tomaschitz, Andreas, Pieber, Thomas R., Fahrleitner-Pammer, Astrid
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2012; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adult; Age; Age Factors; Biological and medical sciences; Body composition; Body Composition - physiology; Body mass index; Bone composition; Bone density; Bone Density - physiology; Bone growth; Bone mass; Bone mineral content; Bone mineral density; Bone Morphogenetic Proteins - blood; Bone Morphogenetic Proteins - metabolism; Calcium - blood; Case-Control Studies; Correlation analysis; Cross-Sectional Studies; Endocrinopathies; Exercise; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gender; Genetic Markers; Health; Humans; Male; Medical sciences; Middle Aged; Motor Activity - physiology; Osteocalcin; Osteocalcin - blood; Osteocytes; Osteogenesis; Physical activity; Population studies; Renal function; Serum levels; Sex Characteristics; Signal transduction; SOST protein; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Wnt protein; Young Adult; β-Catenin; Human; Physical exercise; Obesity; Nutrition; Nutrition disorder; Sex; Metabolic diseases; Body composition; Osteoarticular system; Association; Bone mass; Adult; Bone mineral density; Bone; Age; Endocrinology; Nutritional status

Context:Sclerostin is produced by osteocytes and inhibits bone formation through the Wnt/β-catenin-signaling pathway. Only limited data are available on circulating sclerostin levels in healthy subjects.Objective:We aimed to evaluate the correlation between sclerostin and physical activity, anthropo...