Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren - Vaidyanathan, Sujata; Camenisch, Gian; Schuetz, Helmut; Reynolds, Christine; Yeh, Ching-Ming; Bizot, Marie-Noelle; Dieterich, Hans Armin; Howard, Dan; Dole, William P (Journal of clinical pharmacology, 2008)
Keywords: Adult; Amides - adverse effects; Amides - pharmacokinetics; Animals; Antifungal Agents - adverse effects; Antifungal Agents - pharmacokinetics; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; Caco-2 Cells; Cell Line; Cytochrome P-450 CYP3A - metabolism; Digoxin - adverse effects; Digoxin - pharmacokinetics; Drug Interactions; Female; Fumarates - adverse effects; Fumarates - pharmacokinetics; Heptanoic Acids - adverse effects; Heptanoic Acids - pharmacokinetics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics; Ketoconazole - adverse effects; Ketoconazole - pharmacokinetics; Male; Organic Anion Transporters - metabolism; Pyrroles - adverse effects; Pyrroles - pharmacokinetics; Renin - antagonists & inhibitors; Tissue Distribution; Young Adult