Synthesis and Characterization of Amphiphilic Biodegradable Copolymer, Poly(aspartic acid-co-lactic acid)
An amphiphilic biodegradable polymer, poly(aspartic acid‐co‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid units was confirmed...
Saved in:
| Published in | Macromolecular bioscience Vol. 3; no. 1; pp. 34 - 43 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY-VCH Verlag
01.01.2003
WILEY‐VCH Verlag Wiley-VCH |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | An amphiphilic biodegradable polymer, poly(aspartic acid‐co‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid units was confirmed by IR and NMR spectroscopy. A copolymer of sodium aspartate and lactic acid (PALNa) was prepared by reacting PAL with an aqueous sodium hydroxide solution. The PAL was soluble in many organic solvents, while the PALNa was soluble in methanol and water. The hydrolytic degradation behavior of PAL varied with the copolymer composition. A higher Asp content resulted in a faster molecular weight decrease, and introducing glycolic acid units accelerated the degradation rate.
Microphotograph of microsphere of PAL‐1/5. |
|---|---|
| AbstractList | An amphiphilic biodegradable polymer, poly(aspartic acid‐co‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid units was confirmed by IR and NMR spectroscopy. A copolymer of sodium aspartate and lactic acid (PALNa) was prepared by reacting PAL with an aqueous sodium hydroxide solution. The PAL was soluble in many organic solvents, while the PALNa was soluble in methanol and water. The hydrolytic degradation behavior of PAL varied with the copolymer composition. A higher Asp content resulted in a faster molecular weight decrease, and introducing glycolic acid units accelerated the degradation rate.
Microphotograph of microsphere of PAL‐1/5. Abstract An amphiphilic biodegradable polymer, poly(aspartic acid‐ co ‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L ‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid units was confirmed by IR and NMR spectroscopy. A copolymer of sodium aspartate and lactic acid (PALNa) was prepared by reacting PAL with an aqueous sodium hydroxide solution. The PAL was soluble in many organic solvents, while the PALNa was soluble in methanol and water. The hydrolytic degradation behavior of PAL varied with the copolymer composition. A higher Asp content resulted in a faster molecular weight decrease, and introducing glycolic acid units accelerated the degradation rate. Microphotograph of microsphere of PAL‐1/5. magnified image Microphotograph of microsphere of PAL‐1/5. |
| Author | Shinoda, Hosei Asou, Yukiko Tanaka, Kimiko Suetsugu, Akio |
| Author_xml | – sequence: 1 givenname: Hosei surname: Shinoda fullname: Shinoda, Hosei email: hosei.shinoda@mitsui-chem.co.jp organization: Mitsui Chemicals, Inc., 580-32 Nagaura, Sodegaura City, Chiba 299-0265, Japan – sequence: 2 givenname: Yukiko surname: Asou fullname: Asou, Yukiko organization: Mitsui Chemicals, Inc., 580-32 Nagaura, Sodegaura City, Chiba 299-0265, Japan – sequence: 3 givenname: Akio surname: Suetsugu fullname: Suetsugu, Akio organization: Mitsui Chemical Analysis & Consulting Service Inc., Nagaura, Sodegaura City, Chiba 299-0265, Japan – sequence: 4 givenname: Kimiko surname: Tanaka fullname: Tanaka, Kimiko organization: Mitsui Chemical Analysis & Consulting Service Inc., Nagaura, Sodegaura City, Chiba 299-0265, Japan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14552166$$DView record in Pascal Francis |
| BookMark | eNqFkN1LwzAUxYNMcJu--twXQcHOpG3S9nErbg42FVQGvoS7fLho15akoPOvN2Nj-iYEci_3_M69nB7qVHWlEDoneEAwjm7WsDSDCOM4xxinR6hLGGEhJTntHOosPUE9594xJmmWR11knjZVu1LOuAAqGRQrsCBaZc03tKaugloHw3WzMv6VRgQjU0v1ZkHCslRBUTd1uVkrex08-uISXAO29TIQRoaiDkvvtW-vTtGxhtKps_3fRy_j2-fiLpw9TKbFcBaKhGZpKBVomkQ5IVEcJTERkCwjwvxCKiQVmBGtNNNJBgonGclhyaQfMM0EzqSUcR8Ndr7C1s5ZpXljzRrshhPMt0HxbVD8EJQHLnZAA05AqS1UwrhfKqHUH8C8Lt_pPk2pNv-48vlwNP27I9yxxrXq68CC_eAsjVPKF_cTnhTxeI6LV76IfwByBoxv |
| CitedBy_id | crossref_primary_10_1002_app_34168 crossref_primary_10_1002_macp_201000710 crossref_primary_10_1016_j_polymdegradstab_2020_109216 crossref_primary_10_3390_polym12102324 crossref_primary_10_1039_c2gc35875a crossref_primary_10_1002_app_33074 crossref_primary_10_1007_s10337_012_2180_1 crossref_primary_10_1080_15421401003719787 crossref_primary_10_1007_s10924_013_0587_x crossref_primary_10_1016_j_eurpolymj_2018_08_056 crossref_primary_10_1002_mabi_201100265 crossref_primary_10_1016_j_colsurfa_2012_12_014 crossref_primary_10_1016_j_progpolymsci_2018_10_004 crossref_primary_10_1002_jbm_a_30550 crossref_primary_10_1163_138577210X521314 crossref_primary_10_1007_s00396_007_1713_x crossref_primary_10_1021_acsbiomaterials_1c00150 crossref_primary_10_1016_j_polymer_2005_09_029 crossref_primary_10_1016_j_polymer_2024_127324 crossref_primary_10_1002_app_27549 crossref_primary_10_1002_app_42970 crossref_primary_10_1002_masy_200900103 crossref_primary_10_1080_1023666X_2012_668452 crossref_primary_10_1007_s11458_007_0037_1 crossref_primary_10_1016_j_polymdegradstab_2004_11_003 crossref_primary_10_1021_acs_biomac_7b00016 crossref_primary_10_1016_j_polymdegradstab_2008_11_001 crossref_primary_10_1016_j_ijadhadh_2005_12_004 crossref_primary_10_3724_SP_J_1105_2008_00929 crossref_primary_10_1517_17425247_5_9_979 crossref_primary_10_1016_j_polymdegradstab_2016_10_016 crossref_primary_10_1016_j_polymdegradstab_2009_05_008 crossref_primary_10_1002_app_28944 crossref_primary_10_1007_s00396_005_1432_0 crossref_primary_10_1021_acsapm_4c01179 crossref_primary_10_1007_s11051_011_0387_y crossref_primary_10_1007_s00396_008_1924_9 crossref_primary_10_1007_s11172_018_2115_6 crossref_primary_10_1007_s10856_006_7307_1 crossref_primary_10_1016_j_dib_2016_11_088 crossref_primary_10_1007_s00216_008_2565_z crossref_primary_10_1016_j_progpolymsci_2013_11_007 crossref_primary_10_1177_0885328214533736 crossref_primary_10_1002_polb_22193 crossref_primary_10_1016_j_eurpolymj_2014_07_043 crossref_primary_10_1016_j_polymdegradstab_2020_109323 crossref_primary_10_1002_app_52907 crossref_primary_10_4028_www_scientific_net_AMR_739_3 crossref_primary_10_1002_masy_200851210 crossref_primary_10_1080_00914037_2022_2029440 crossref_primary_10_1002_app_31943 |
| Cites_doi | 10.1016/0142-9612(81)90060-0 10.1021/ma950529u 10.1021/ma00106a004 10.1002/app.1991.070431117 10.1002/(SICI)1521-3935(19990201)200:2<436::AID-MACP436>3.0.CO;2-6 10.1080/10601329608010880 10.1021/ma961579h 10.1021/ma9712108 10.1002/1521-4095(200012)12:23<1841::AID-ADMA1841>3.0.CO;2-E 10.1021/jm00266a006 10.1002/jbm.820240804 10.1016/0142-9612(87)90034-2 10.1080/10601329508010289 10.1002/app.1984.070290913 10.1007/BF02068677 10.1002/macp.1990.021911007 10.1021/jo01063a026 10.1016/S0142-9612(98)00066-0 10.1016/S0032-3861(00)00889-2 10.1016/0010-7824(73)90033-4 10.1007/BF02763661 10.1021/ma961411w 10.1016/0168-3659(93)90103-C 10.1021/cr000108x 10.1002/macp.1992.021931101 10.1016/0032-3861(81)90168-3 10.1021/ma00104a016 10.1248/cpb.33.1195 10.1002/jab.770010109 10.1021/bm9900038 10.1002/jbm.820231003 10.1016/0032-3861(93)90212-S 10.1021/ma9701752 10.1016/0030-4220(71)90044-2 10.1002/(SICI)1097-4636(199604)30:4<553::AID-JBM14>3.0.CO;2-I |
| ContentType | Journal Article |
| Copyright | 2002 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2003 INIST-CNRS |
| Copyright_xml | – notice: 2002 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim – notice: 2003 INIST-CNRS |
| DBID | BSCLL IQODW AAYXX CITATION |
| DOI | 10.1002/mabi.200390007 |
| DatabaseName | Istex Pascal-Francis CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | CrossRef |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Applied Sciences |
| EISSN | 1616-5195 |
| EndPage | 43 |
| ExternalDocumentID | 10_1002_mabi_200390007 14552166 MABI200390007 ark_67375_WNG_4C3FM0CZ_W |
| Genre | article |
| GroupedDBID | --- -~X .3N .GA .Y3 05W 0R~ 10A 1L6 1OC 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABLJU ABPVW ABTAH ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BSCLL BY8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ O66 O9- OIG P2P P2W P2X P4D Q.N Q11 QB0 QRW R.K ROL RWI RX1 RYL SUPJJ SV3 UB1 V2E W8V W99 WBKPD WFSAM WIH WIK WJL WOHZO WQJ WRC WXSBR WYISQ XG1 XV2 ZY4 ZZTAW ~IA ~WT AAPBV ABHUG ACXME ADAWD ADDAD AFVGU AGJLS IQODW AAYXX CITATION |
| ID | FETCH-LOGICAL-c4587-deaf542911232431ca4b216dab5cd5c061fef6f48ae04819ab6dcd56f6c08ddd3 |
| IEDL.DBID | DR2 |
| ISSN | 1616-5187 |
| IngestDate | Fri Aug 23 01:56:13 EDT 2024 Sun Oct 22 16:09:43 EDT 2023 Sat Aug 24 00:59:20 EDT 2024 Wed Oct 30 09:55:07 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Biological properties Lactone copolymer Property composition relationship Molecular structure Biodegradability Cyclopolymerization Lactic acid copolymer Condensation polymerization Aspartic derivative copolymer Experimental study In vitro Hydrolysis Chemical modification Preparation Aspartic acid Imide copolymer Carboxylate copolymer Aliphatic copolymer Amphiphilic polymer |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4587-deaf542911232431ca4b216dab5cd5c061fef6f48ae04819ab6dcd56f6c08ddd3 |
| Notes | ark:/67375/WNG-4C3FM0CZ-W istex:4333185E2103D5990191DA29ECFCBB6A3E13A154 ArticleID:MABI200390007 |
| PageCount | 10 |
| ParticipantIDs | crossref_primary_10_1002_mabi_200390007 pascalfrancis_primary_14552166 wiley_primary_10_1002_mabi_200390007_MABI200390007 istex_primary_ark_67375_WNG_4C3FM0CZ_W |
| PublicationCentury | 2000 |
| PublicationDate | January 2003 |
| PublicationDateYYYYMMDD | 2003-01-01 |
| PublicationDate_xml | – month: 01 year: 2003 text: January 2003 |
| PublicationDecade | 2000 |
| PublicationPlace | Weinheim |
| PublicationPlace_xml | – name: Weinheim |
| PublicationTitle | Macromolecular bioscience |
| PublicationTitleAlternate | Macromol. Biosci |
| PublicationYear | 2003 |
| Publisher | WILEY-VCH Verlag WILEY‐VCH Verlag Wiley-VCH |
| Publisher_xml | – name: WILEY-VCH Verlag – name: WILEY‐VCH Verlag – name: Wiley-VCH |
| References | R. G. Sinclair, J. Macromol. Sci. Pure Appl. Chem. 1996, A33, 585. J. Elisseeff, K. Anseth, R. Langer, J. S. Hrkach, Macromolecules 1997, 30, 2182. S.-I. Moon, C.-W. Lee, I. Taniguchi, Y. Kimura, Polymer 2001, 42, 5059. T. M. Jackanicz, H. K. Nash, D. L. Wise, J. B. Gregory, Contraception 1973, 8, 227. R. R. M. Bos, F. R. Rozema, G. Boering, A. J. Nijenhuis, A. J. Pennings, Adv. Biomater. 1992, 10, 405. K. Makino, M. Arakawa, T. Kondo, Chem. Pharm. Bull. 1985, 33, 1195. R. E. Drumright, P. R. Gruber, D. E. Henton, Adv. Mater. 2000, 12, 1841. J. Kovacs, H. N. Kovacs, I. Konyves, J. Csaszar, T. Vajda, H. Mix, J. Org. Chem. 1961, 26, 1084. [Chem. Abstr. 1995, 122, 58909]. K. Tabata, H. Abe, Y. Doi, Biomacromolecules 2000, 1, 157. Y. Ikada, Y. Shikinami, Y. Hara, M. Tagawa, E. Fukada, J. Biomed. Mater. Res. 1996, 30, 553. J.-H. Zhu, Z.-R. Shen, L.-T. Wu, S.-L. Yang, J. Appl. Polym. Sci. 1991, 43, 2099. C. G. Pitt, M. M. Gratzl, G. L. Kimmel, J. Surles, A. Schindler, Biomaterials 1981, 2, 215. J. Helder, P. J. Dijkstra, J. Feijen, J. Biomed. Mater. Res. 1990, 24, 1005. [Chem. Abstr. 1997, 126, 317833]. J. P. Pennings, H. Dijkstra, A. J. Pennings, Polymer 1993, 34, 942. [Chem. Abstr. 1994, 121, 282692]. D. E. Cutright, E. E. Hunsuck, Oral Surg. Oral Med. Oral Pathol. 1971, 31, 134. K. E. Gonsalves, S. Jin, M.-I. Baraton, Biomaterials 1998, 19, 1501. P. D. Sholes, A. G. A. Coombes, L. Illum, S. S. Davis, M. Vert, M. C. Davies, J. Controlled Release 1993, 25, 145. N. Kawashima, S. Ogawa, S. Obuchi, M. Matsuo, T. Yagi, in Biopolymers, Vol. 4, Y. Doi, A. Steinbuchel, Eds., 2002, 251. D. A. Barrera, E. Zylstra, P. T. Lansbury, R. Langer, Macromolecules 1995, 28, 425. K. Matsubara, T. Nakato, M. Tomida, Macromolecules 1998, 31, 1466. D. Wang, X.-D. Feng, Macromolecules 1997, 30, 5688. [Chem. Abstr. 1995, 123, 257943]. [Chem. Abstr. 1993, 118, 22835]. J. L. Espartero, I. Rashkov, S. M. Li, N. Manolova, M. Vert, Macromolecules 1996, 29, 3535. K. Matsubara, T. Nakato, M. Tomida, Macromolecules 1997, 30, 2305. K. Matsubara, T. Nakato, M. Tomida, Polymer Preprints 1996, 37(1), 699. [Chem. Abstr. 1994, 120, 9195]. P. J. in'tVeld, P. J. Dijkstra, J. Feijen, Makromol. Chem. 1992, 193, 2713. M. Vert, G. Schwarch, J. Coudane, J. Macromol. Sci. Pure Appl. Chem. 1995, A32, 787. P. Neri, G. Antoni, F. Benvenuti, F. Cocola, G. Gazzei, J. Med. Chem. 1973, 16, 893. R. Westervelt, Chem. Week 2000, 162, 9. A. M. Reed, D. K. Gilding, Polymer 1981, 22, 494. A. U. Daniels, M. K. D. Chang, K. P. Andriano, J. Appl. Biomater. 1990, 1, 57. S. K. Wolk, G. Swift, Y. H. Paik, Macromolecules 1994, 27, 7613. M. Ajioka, K. Enomoto, K. Suzuki, A. Yamaguchi, J. Environ. Polym. Degrad. 1995, 3, 225. T. Ouchi, A. Hamada, Y. Ohya, Macromol. Chem. Phys. 1999, 200, 436. J. W. Leenslag, A. J. Pennings, R. R. M. Boss, F. R. Rozema, G. Boering, Biomaterials 1987, 8, 70. M. Bero, J. Kasperczyk, Z. J. Jedlinski, Makromol. Chem. 1990, 191, 2287. K. Y. Lee, D. J. Mooney, Chem. Rev. 2001, 101, 1869. J. W. Leenslag, S. Gogolewski, A. J. Pennings, J. Appl. Polym. Sci. 1984, 29, 2829. [Chem. Abstr. 1975, 82, 126912]. S. Roweton, S. J. Huang, G. Swift, J. Environ. Polym. Degrad. 1997, 5, 175. T. Nakamura, S. Hitomi, S. Watanabe, Y. Shimizu, K. Jamshidi, S.-H. Hyon, Y. Ikada, J. Biomed. Mater. Res. 1989, 23, 1115. M. Chasin, R. Langer, "Biodegradable Polymers as Drug Delivery Systems", Marcel Dekker, New York 1990. 1993; 25 2001; 101 1989; 23 1995; A32 1987; 8 1981; 2 1992 1993; 118 1973; 16 1994 1994; 121 1996; 30 2002; 4 1984; 29 1994; 27 2000; 1 1997 1997; 126 1999; 200 1997; 5 1992; 10 1995; 3 1996; 37 2001; 42 1995 1995; 123 1981; 22 1971; 31 1990; 1 1993; 34 1996; A33 1994 1995; 122 1996; 29 1992; 193 1998; 19 1990; 24 1990 1995; 28 2000; 12 1991; 43 1997; 30 2000; 162 1990; 191 1995 1994; 120 1985; 33 1974 1975; 82 1973; 8 1998; 31 1961; 26 e_1_2_5_27_2 Roweton S. (e_1_2_5_21_2) 1997; 5 Bos R. R. M. (e_1_2_5_9_2) 1992; 10 e_1_2_5_25_2 e_1_2_5_46_2 e_1_2_5_23_2 e_1_2_5_44_2 e_1_2_5_42_2 e_1_2_5_29_2 e_1_2_5_13_2 e_1_2_5_38_2 e_1_2_5_15_2 e_1_2_5_36_2 e_1_2_5_7_2 e_1_2_5_34_2 e_1_2_5_5_2 e_1_2_5_11_2 (e_1_2_5_28_3) 1997; 126 e_1_2_5_32_2 e_1_2_5_3_2 e_1_2_5_1_2 (e_1_2_5_13_3) 1993; 118 e_1_2_5_17_2 (e_1_2_5_25_3) 1994; 121 e_1_2_5_19_2 Matsubara K. (e_1_2_5_40_2) 1996; 37 (e_1_2_5_14_3) 1994; 120 e_1_2_5_30_2 (e_1_2_5_24_3) 1995; 122 e_1_2_5_26_2 Chasin M. (e_1_2_5_2_2) 1990 e_1_2_5_24_2 e_1_2_5_47_2 (e_1_2_5_26_3) 1995; 123 e_1_2_5_22_2 e_1_2_5_45_2 e_1_2_5_43_2 e_1_2_5_28_2 e_1_2_5_41_2 e_1_2_5_14_2 e_1_2_5_37_2 e_1_2_5_35_2 e_1_2_5_8_2 e_1_2_5_10_2 e_1_2_5_33_2 e_1_2_5_6_2 e_1_2_5_12_2 e_1_2_5_31_2 e_1_2_5_4_2 Westervelt R. (e_1_2_5_20_2) 2000; 162 Kawashima N. (e_1_2_5_16_2) 2002 e_1_2_5_18_2 e_1_2_5_39_2 (e_1_2_5_27_3) 1975; 82 |
| References_xml | – volume: 4 start-page: 251 year: 2002 – volume: 162 start-page: 9 year: 2000 publication-title: Chem. Week – volume: 33 start-page: 1195 year: 1985 publication-title: Chem. Pharm. Bull. – volume: 120 start-page: 9195 year: 1995 1994 publication-title: Chem. Abstr. – volume: 42 start-page: 5059 year: 2001 publication-title: Polymer – volume: 22 start-page: 494 year: 1981 publication-title: Polymer – volume: 19 start-page: 1501 year: 1998 publication-title: Biomaterials – volume: 27 start-page: 7613 year: 1994 publication-title: Macromolecules – volume: 118 start-page: 22835 year: 1992 1993 publication-title: Chem. Abstr. – volume: 12 start-page: 1841 year: 2000 publication-title: Adv. Mater. – volume: 123 start-page: 257943 year: 1995 1995 publication-title: Chem. Abstr. – volume: 29 start-page: 3535 year: 1996 publication-title: Macromolecules – volume: 1 start-page: 57 year: 1990 publication-title: J. Appl. Biomater. – volume: 5 start-page: 175 year: 1997 publication-title: J. Environ. Polym. Degrad. – volume: 30 start-page: 2182 year: 1997 publication-title: Macromolecules – volume: A32 start-page: 787 year: 1995 publication-title: J. Macromol. Sci. Pure Appl. Chem. – volume: 28 start-page: 425 year: 1995 publication-title: Macromolecules – volume: 200 start-page: 436 year: 1999 publication-title: Macromol. Chem. Phys. – volume: 10 start-page: 405 year: 1992 publication-title: Adv. Biomater. – year: 1990 – volume: 31 start-page: 134 year: 1971 publication-title: Oral Surg. Oral Med. Oral Pathol. – volume: 101 start-page: 1869 year: 2001 publication-title: Chem. Rev. – volume: 191 start-page: 2287 year: 1990 publication-title: Makromol. Chem. – volume: 8 start-page: 70 year: 1987 publication-title: Biomaterials – volume: 30 start-page: 553 year: 1996 publication-title: J. Biomed. Mater. Res. – volume: 26 start-page: 1084 year: 1961 publication-title: J. Org. Chem. – volume: 82 start-page: 126912 year: 1974 1975 publication-title: Chem. Abstr. – volume: 126 start-page: 317833 year: 1997 1997 publication-title: Chem. Abstr. – volume: 193 start-page: 2713 year: 1992 publication-title: Makromol. Chem. – volume: 3 start-page: 225 year: 1995 publication-title: J. Environ. Polym. Degrad. – volume: 43 start-page: 2099 year: 1991 publication-title: J. Appl. Polym. Sci. – volume: 8 start-page: 227 year: 1973 publication-title: Contraception – volume: A33 start-page: 585 year: 1996 publication-title: J. Macromol. Sci. Pure Appl. Chem. – volume: 23 start-page: 1115 year: 1989 publication-title: J. Biomed. Mater. Res. – volume: 34 start-page: 942 year: 1993 publication-title: Polymer – volume: 121 start-page: 282692 year: 1994 1994 publication-title: Chem. Abstr. – volume: 30 start-page: 5688 year: 1997 publication-title: Macromolecules – volume: 2 start-page: 215 year: 1981 publication-title: Biomaterials – volume: 24 start-page: 1005 year: 1990 publication-title: J. Biomed. Mater. Res. – volume: 30 start-page: 2305 year: 1997 publication-title: Macromolecules – volume: 122 start-page: 58909 year: 1994 1995 publication-title: Chem. Abstr. – volume: 16 start-page: 893 year: 1973 publication-title: J. Med. Chem. – volume: 37 start-page: 699 issue: 1 year: 1996 publication-title: Polymer Preprints – volume: 25 start-page: 145 year: 1993 publication-title: J. Controlled Release – volume: 31 start-page: 1466 year: 1998 publication-title: Macromolecules – volume: 29 start-page: 2829 year: 1984 publication-title: J. Appl. Polym. Sci. – volume: 1 start-page: 157 year: 2000 publication-title: Biomacromolecules – ident: e_1_2_5_46_2 doi: 10.1016/0142-9612(81)90060-0 – ident: e_1_2_5_37_2 doi: 10.1021/ma950529u – ident: e_1_2_5_31_2 doi: 10.1021/ma00106a004 – volume: 122 start-page: 58909 year: 1995 ident: e_1_2_5_24_3 publication-title: Chem. Abstr. – ident: e_1_2_5_45_2 doi: 10.1002/app.1991.070431117 – ident: e_1_2_5_35_2 doi: 10.1002/(SICI)1521-3935(19990201)200:2<436::AID-MACP436>3.0.CO;2-6 – ident: e_1_2_5_18_2 doi: 10.1080/10601329608010880 – ident: e_1_2_5_38_2 doi: 10.1021/ma961579h – ident: e_1_2_5_24_2 – ident: e_1_2_5_41_2 doi: 10.1021/ma9712108 – volume: 123 start-page: 257943 year: 1995 ident: e_1_2_5_26_3 publication-title: Chem. Abstr. – ident: e_1_2_5_19_2 doi: 10.1002/1521-4095(200012)12:23<1841::AID-ADMA1841>3.0.CO;2-E – ident: e_1_2_5_36_2 doi: 10.1021/jm00266a006 – ident: e_1_2_5_26_2 – ident: e_1_2_5_29_2 doi: 10.1002/jbm.820240804 – ident: e_1_2_5_8_2 doi: 10.1016/0142-9612(87)90034-2 – volume: 126 start-page: 317833 year: 1997 ident: e_1_2_5_28_3 publication-title: Chem. Abstr. – ident: e_1_2_5_1_2 doi: 10.1080/10601329508010289 – ident: e_1_2_5_7_2 doi: 10.1002/app.1984.070290913 – ident: e_1_2_5_15_2 doi: 10.1007/BF02068677 – ident: e_1_2_5_42_2 doi: 10.1002/macp.1990.021911007 – ident: e_1_2_5_22_2 doi: 10.1021/jo01063a026 – ident: e_1_2_5_32_2 doi: 10.1016/S0142-9612(98)00066-0 – volume: 121 start-page: 282692 year: 1994 ident: e_1_2_5_25_3 publication-title: Chem. Abstr. – ident: e_1_2_5_17_2 doi: 10.1016/S0032-3861(00)00889-2 – ident: e_1_2_5_3_2 doi: 10.1016/0010-7824(73)90033-4 – volume: 5 start-page: 175 year: 1997 ident: e_1_2_5_21_2 publication-title: J. Environ. Polym. Degrad. doi: 10.1007/BF02763661 contributor: fullname: Roweton S. – ident: e_1_2_5_34_2 doi: 10.1021/ma961411w – ident: e_1_2_5_47_2 doi: 10.1016/0168-3659(93)90103-C – ident: e_1_2_5_11_2 doi: 10.1021/cr000108x – ident: e_1_2_5_13_2 – ident: e_1_2_5_30_2 doi: 10.1002/macp.1992.021931101 – ident: e_1_2_5_43_2 doi: 10.1016/0032-3861(81)90168-3 – start-page: 251 volume-title: Biopolymers year: 2002 ident: e_1_2_5_16_2 contributor: fullname: Kawashima N. – ident: e_1_2_5_39_2 doi: 10.1021/ma00104a016 – volume: 10 start-page: 405 year: 1992 ident: e_1_2_5_9_2 publication-title: Adv. Biomater. contributor: fullname: Bos R. R. M. – ident: e_1_2_5_4_2 doi: 10.1248/cpb.33.1195 – volume: 82 start-page: 126912 year: 1975 ident: e_1_2_5_27_3 publication-title: Chem. Abstr. – ident: e_1_2_5_12_2 doi: 10.1002/jab.770010109 – ident: e_1_2_5_27_2 – volume: 162 start-page: 9 year: 2000 ident: e_1_2_5_20_2 publication-title: Chem. Week contributor: fullname: Westervelt R. – ident: e_1_2_5_23_2 doi: 10.1021/bm9900038 – volume: 37 start-page: 699 issue: 1 year: 1996 ident: e_1_2_5_40_2 publication-title: Polymer Preprints contributor: fullname: Matsubara K. – ident: e_1_2_5_44_2 doi: 10.1002/jbm.820231003 – volume: 120 start-page: 9195 year: 1994 ident: e_1_2_5_14_3 publication-title: Chem. Abstr. – ident: e_1_2_5_5_2 doi: 10.1016/0032-3861(93)90212-S – ident: e_1_2_5_14_2 – ident: e_1_2_5_33_2 doi: 10.1021/ma9701752 – ident: e_1_2_5_28_2 – volume-title: Biodegradable Polymers as Drug Delivery Systems year: 1990 ident: e_1_2_5_2_2 contributor: fullname: Chasin M. – volume: 118 start-page: 22835 year: 1993 ident: e_1_2_5_13_3 publication-title: Chem. Abstr. – ident: e_1_2_5_25_2 – ident: e_1_2_5_6_2 doi: 10.1016/0030-4220(71)90044-2 – ident: e_1_2_5_10_2 doi: 10.1002/(SICI)1097-4636(199604)30:4<553::AID-JBM14>3.0.CO;2-I |
| SSID | ssj0017892 |
| Score | 1.9542851 |
| Snippet | An amphiphilic biodegradable polymer, poly(aspartic acid‐co‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and... Abstract An amphiphilic biodegradable polymer, poly(aspartic acid‐ co ‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp)... |
| SourceID | crossref pascalfrancis wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 34 |
| SubjectTerms | Aminoacid polymers Applied sciences biodegradable copolymerization drug delivery systems Exact sciences and technology Physicochemistry of polymers renewable resources Synthetic biopolymers |
| Title | Synthesis and Characterization of Amphiphilic Biodegradable Copolymer, Poly(aspartic acid-co-lactic acid) |
| URI | https://api.istex.fr/ark:/67375/WNG-4C3FM0CZ-W/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmabi.200390007 |
| Volume | 3 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF5V4VAuPAoI86j2UBWQ6tSvXdvH1JAWpEYIqBJxsWZfktXGqfKQmp74CfxGfgmz68ZpekEqF8uv9dozs7OfVzPfELLHQcscQPhcQOSjUUgf4iDwWZ4h_s2TyBgXbTHgJ2fJlxEb3crib_gh2gU3OzKcv7YDHMTscE0aOgZROT5PW_bSppOHcWpjuj5-a_mjwjRzVZER1XCfhVm6Ym0MosPN5huz0gMr4CsbJQkzFJRpKlxsolc3_fQfE1i9eBN1ct5dzEVXXt_hdPyfL3tCHt1gU9prjOkp2dL1DtkuViXhnpHx92WNgHFWzSjUihYt2XOTy0knhvbQOqpLu0oj6VE1UZaLQtn0LFrYcgzLsZ4e0K-48x7Ql9meKMhK_fn1W05wc-FyttypD8_JWf_Tj-LEv6nX4MuEoa9SGowtfxU6mBaHEhIRhRw7YVIxicjBaMNNkoG2LDU5CK7wAjdcBplSKn5BOvWk1i8JZUrHucpDmQr840tUjjApi3kaawgYRKlH3q30VV42tBxlQ8AclVZ8ZSs-j-w7dba3wfTcBrOlrBwOjsukiPunQfGzHHpkd0Pf6-cmDDEO5x6JnNb-0WF52jv63B69uk-j1-Shixl0Kz1vSGc-Xei3iH3mYtfZ91-Ar_2r |
| link.rule.ids | 315,783,787,1378,27938,27939,46308,46732 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB5RONBL31W3D-pD1YdEIC87yXEJbJeWXSEKourF8lOK6GbR7iKVnvoT-hv7Sxg7JGh7QWovUV6Ok5mx_WU08w3AGyaMKoSQAZMiDtAoVCCSMAxokSP-LdLYWh9tMWbDk_TTV9pGE7pcmIYfonO4uZHh52s3wJ1DevuGNXQiZOUJPV3dy-wOrOGYT1wRg92jjkEqynJfFxlxDQtolGctb2MYby-3X1qX1pyIf7g4STFHUdmmxsUyfvUL0OA-yPbVm7iTs62LhdxSP_9idfyvb3sA967hKek39vQQVkz9CNbLtircY5h8uawRM86rORG1JmXH99ykc5KpJX00kOrcOWoU2amm2tFRaJehRUpXkeFyYmab5BB33guczlxPRKhK__n1W01x892nbflTH57AyWDvuBwG1yUbApVSnK60EdZVwIo8UksiJVIZRww7oUpTheDBGstsmgvjiGoKIZnGC8wyFeZa6-QprNbT2jwDQrVJCl1EKpP405fqApFSnqCKjQipiLMevGsVxs8bZg7ecDDH3ImPd-LrwVuvz-42MTtz8WwZ5afjjzwtk8EoLL_x0x5sLCn85rkpRZjDWA9ir7ZbOuSj_s5-d_T8Xxq9hvXh8eiAH-yPP7-Auz6E0Dt-XsLqYnZhXiEUWsgNb-xXUqkB1A |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bT9RAFD5RSNQXAS9xFXAeDGpioZeZafu4FFcQ2RCQQHyZnM4laXC7m90lEZ_8Cf5GfgkzU7a4vpjIS9PbdNpzzpz5OjnnOwBvOGqZI5YBLzEOrFHIAJMwDFieWfyb09gYH23R57sn9PMZO_sji7_hh2gX3NzI8P7aDfCRMlu3pKEDLCvP5-nKXqb3YZHyJHRBXTtHLYFUlGa-LLKFNTxgUZbOaBvDeGu-_dy0tOgk_MOFSeLESso0JS7m4auff3pLgLM3b8JOzjcvpuWm_PkXqeNdPm0ZHt-AU9JtrGkF7un6CTwsZjXhnsLg-LK2iHFSTQjWihQt23OTzEmGhnSteVQjt0wjyXY1VI6MQrn8LFK4egyXAz3-QA7tzju0zsz1RFBW6urXbzm0m-8-acufev8MTnofvxa7wU3BhkBSZp2V0mhc_avI47QkkkjLOOK2EyYVkxY6GG24oRlqR1OTY8mVvcANl2GmlEqew0I9rPULIEzpJFd5JNPS_vJRlVuclCU8TTSGDOO0A29n-hKjhpdDNAzMsXDiE634OrDh1dnehuNzF82WMnHa_yRokfQOwuKbOO3A-py-b59LmQU5nHcg9lr7R4fioLu91x69_J9Gr-HB4U5PfNnr77-CRz5-0K_6rMLCdHyh1ywOmpbr3tSvAU8fAIM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+Characterization+of+Amphiphilic+Biodegradable+Copolymer%2C+Poly%28aspartic+acid%E2%80%90+co+%E2%80%90lactic+acid%29&rft.jtitle=Macromolecular+bioscience&rft.au=Shinoda%2C+Hosei&rft.au=Asou%2C+Yukiko&rft.au=Suetsugu%2C+Akio&rft.au=Tanaka%2C+Kimiko&rft.date=2003-01-01&rft.issn=1616-5187&rft.eissn=1616-5195&rft.volume=3&rft.issue=1&rft.spage=34&rft.epage=43&rft_id=info:doi/10.1002%2Fmabi.200390007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_mabi_200390007 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1616-5187&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1616-5187&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1616-5187&client=summon |