Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy

• Published in: Lasers in surgery and medicine Vol. 38; no. 8; pp. 754 - 761
• Main Authors: Li, Heng, Standish, Beau A., Mariampillai, Adrian, Munce, Nigel R., Mao, Youxin, Chiu, Stephanie, Marcon, Norman E., Wilson, Brian C., Vitkin, Alex, Yang, Victor X.D.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2006
• Subjects: Animals; Cell Line, Tumor; Dihematoporphyrin Ether - pharmacology; Doppler blood flow imaging; Equipment Design; Feasibility Studies; interstitial fiber sensors; Male; Microcirculation - drug effects; Neoplasm Transplantation; optical coherence tomography; Photochemotherapy; photodynamic therapy; Photosensitizing Agents - pharmacology; Prostatic Neoplasms - blood supply; Prostatic Neoplasms - drug therapy; Rats; Tomography, Optical Coherence - instrumentation; Ultrasonography, Doppler, Color

Introduction Doppler optical coherence tomography (DOCT) is an emerging imaging modality that provides subsurface microstructural and microvascular tissue images with near histological resolution and sub‐mm/second velocity sensitivity. A key drawback of OCT for some applications is its shallow (1–3...