A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

• Published in: Alzheimer's & dementia Vol. 15; no. 5; pp. 625 - 634
• Main Authors: Fortier, Mélanie, Castellano, Christian-Alexandre, Croteau, Etienne, Langlois, Francis, Bocti, Christian, St-Pierre, Valérie, Vandenberghe, Camille, Bernier, Michaël, Roy, Maggie, Descoteaux, Maxime, Whittingstall, Kevin, Lepage, Martin, Turcotte, Éric E., Fulop, Tamas, Cunnane, Stephen C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: Acetoacetate; Aged; Alzheimer's disease; Beta-hydroxybutyrate; Brain - metabolism; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - metabolism; Decanoic acid; Energy Metabolism - physiology; Female; Fluorodeoxyglucose; Fluorodeoxyglucose F18 - metabolism; Glucose; Glucose - metabolism; Humans; Ketone; Ketones - administration & dosage; Ketones - metabolism; Male; Medium chain triglyceride; Mild cognitive impairment; Neuropsychological Tests - statistics & numerical data; Octanoic acid; PET imaging; Positron-Emission Tomography; Medium chain triglyceride; Decanoic acid; PET imaging; Mild cognitive impairment; Beta-hydroxybutyrate; Fluorodeoxyglucose; Glucose; Alzheimer's disease; Ketone; Octanoic acid; Acetoacetate

Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to...