A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to...

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Published inAlzheimer's & dementia Vol. 15; no. 5; pp. 625 - 634
Main Authors Fortier, Mélanie, Castellano, Christian-Alexandre, Croteau, Etienne, Langlois, Francis, Bocti, Christian, St-Pierre, Valérie, Vandenberghe, Camille, Bernier, Michaël, Roy, Maggie, Descoteaux, Maxime, Whittingstall, Kevin, Lepage, Martin, Turcotte, Éric E., Fulop, Tamas, Cunnane, Stephen C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2019
Subjects
Acetoacetate
Aged
Alzheimer's disease
Beta-hydroxybutyrate
Brain - metabolism
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - metabolism
Decanoic acid
Energy Metabolism - physiology
Female
Fluorodeoxyglucose
Fluorodeoxyglucose F18 - metabolism
Glucose
Glucose - metabolism
Humans
Ketone
Ketones - administration & dosage
Ketones - metabolism
Male
Medium chain triglyceride
Mild cognitive impairment
Neuropsychological Tests - statistics & numerical data
Octanoic acid
PET imaging
Positron-Emission Tomography
Medium chain triglyceride
Decanoic acid
PET imaging
Mild cognitive impairment
Beta-hydroxybutyrate
Fluorodeoxyglucose
Glucose
Alzheimer's disease
Ketone
Octanoic acid
Acetoacetate
Online AccessGet full text

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Abstract Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention. A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI. •30 g/day of medium chain triglyceride (kMCT) doubles brain ketone metabolism in MCI.•As a result, net brain energy status improved on the kMCT.•Improvement in some cognitive outcomes was positively related to brain ketone uptake.•Both the kMCT and placebo were moderately well tolerated.
AbstractList Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel.INTRODUCTIONUnlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel.Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later.METHODSFifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later.Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention.RESULTSBrain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention.A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.DISCUSSIONA dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.
Introduction Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Methods Fifty‐two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Results Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy‐five percent of participants completed the intervention. Discussion A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.
Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention. A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.
Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain with more fuel. Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later. Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention. A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI. •30 g/day of medium chain triglyceride (kMCT) doubles brain ketone metabolism in MCI.•As a result, net brain energy status improved on the kMCT.•Improvement in some cognitive outcomes was positively related to brain ketone uptake.•Both the kMCT and placebo were moderately well tolerated.
Author Castellano, Christian-Alexandre
Descoteaux, Maxime
Bocti, Christian
Whittingstall, Kevin
Cunnane, Stephen C.
Fortier, Mélanie
Lepage, Martin
Vandenberghe, Camille
Bernier, Michaël
St-Pierre, Valérie
Roy, Maggie
Langlois, Francis
Croteau, Etienne
Turcotte, Éric E.
Fulop, Tamas
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31027873$$D View this record in MEDLINE/PubMed
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2019 The Alzheimer's Association
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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IngestDate Thu Jul 10 22:47:30 EDT 2025
Mon Jul 21 05:55:02 EDT 2025
Tue Jul 01 00:19:44 EDT 2025
Thu Apr 24 22:56:55 EDT 2025
Wed Jan 22 16:40:17 EST 2025
Fri Feb 23 02:17:36 EST 2024
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Issue 5
Keywords Medium chain triglyceride
Decanoic acid
PET imaging
Mild cognitive impairment
Beta-hydroxybutyrate
Fluorodeoxyglucose
Glucose
Alzheimer's disease
Ketone
Octanoic acid
Acetoacetate
Language English
License Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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PublicationTitle Alzheimer's & dementia
PublicationTitleAlternate Alzheimers Dement
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Snippet Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain...
Introduction Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium...
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wiley
elsevier
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SubjectTerms Acetoacetate
Aged
Alzheimer's disease
Beta-hydroxybutyrate
Brain - metabolism
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - metabolism
Decanoic acid
Energy Metabolism - physiology
Female
Fluorodeoxyglucose
Fluorodeoxyglucose F18 - metabolism
Glucose
Glucose - metabolism
Humans
Ketone
Ketones - administration & dosage
Ketones - metabolism
Male
Medium chain triglyceride
Mild cognitive impairment
Neuropsychological Tests - statistics & numerical data
Octanoic acid
PET imaging
Positron-Emission Tomography
Title A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
URI https://dx.doi.org/10.1016/j.jalz.2018.12.017
https://onlinelibrary.wiley.com/doi/abs/10.1016%2Fj.jalz.2018.12.017
https://www.ncbi.nlm.nih.gov/pubmed/31027873
https://www.proquest.com/docview/2216289593
Volume 15
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