T-cell stimulation with purified mycobacterial antigens in patients and healthy subjects infected with Mycobacterium leprae: secreted antigen 85 is another immunodominant antigen

• Published in: Scandinavian journal of immunology Vol. 38; no. 2; p. 167
• Main Authors: Launois, P, Niang, M N, Sarthou, J L, Rivier, F, Drowart, A, Van Vooren, J P, Millan, J, Huygen, K
• Format: Journal Article
• Language: English
• Published: England 01.08.1993
• Subjects: Antigens, Bacterial - immunology; Bacterial Proteins - immunology; Heat-Shock Proteins - immunology; Humans; Interferon-gamma - physiology; Leprosy - immunology; Lymphocyte Activation; Mycobacterium bovis - immunology; Mycobacterium leprae - immunology; T-Lymphocytes - immunology

Peripheral blood leucocytes from 9 paucibacillary and 12 multibacillary leprosy patients, from 18 healthy controls and from 34 healthy leprosy contacts were stimulated with three mycobacterial heat shock proteins with respective molecular weights of 70, 65 and 18 kDa and with the secreted 30-32 kDa...