Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes

• Published in: Advanced functional materials Vol. 31; no. 5; pp. 2006116 - n/a
• Main Authors: Rizwan, Muhammad, Fokina, Ana, Kivijärvi, Tove, Ogawa, Mina, Kufleitner, Markus, Laselva, Onofrio, Smith, Laura J., Bear, Christine E., Ogawa, Shinichiro, Keller, Gordon, Shoichet, Molly S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.01.2021
• Subjects: Cystic fibrosis; Differentiation (biology); Fluorescence; hepatoblast differentiation; hyaluronan; Hyaluronic acid; hydrogel; Hydrogels; Liver; Materials science; notch signaling; photocaging; Signaling; Stem cells

Cholangiocytes form an intricate network of bile ducts to enable proper liver function; yet, recapitulating human stem cell differentiation to cholangiocytes in vitro requires Notch signaling and soluble ligands do not activate the Notch pathway. To overcome these limitations, jagged1 is immobilized...