Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant

• Published in: The New England journal of medicine Vol. 358; no. 4; pp. 369 - 374
• Main Authors: Alexander, Stephen I, Smith, Neil, Smith, Arabella, Hu, Min, Verran, Deborah, Shun, Albert, Dorney, Stuart, Webster, Boyd, Shaw, Peter John, Lammi, Ahti, Stormon, Michael O
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 24.01.2008
• Subjects: Biological and medical sciences; Child; Female; General aspects; Graft vs Host Disease; Hemolysis - immunology; Humans; Immunosuppression; Liver Failure, Acute - surgery; Liver Transplantation - immunology; Medical sciences; T-Lymphocytes - immunology; Transplantation Chimera - immunology; Transplantation Tolerance - genetics; Transplantation Tolerance - immunology; Transplantation, Homologous; Human; Medicine; Treatment; Donor; Surgery; Liver; Tolerance; Graft; Recipient; Transplantation; Chimerism; Cadaver

Complete hematopoietic chimerism and tolerance to a liver allograft developed in a 9-year-old girl who received a liver transplant from a deceased male donor. Tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies. The hemolysis...