Chemerin activation in human obesity

• Published in: Obesity (Silver Spring, Md.) Vol. 24; no. 7; pp. 1522 - 1529
• Main Authors: Chang, Shwu‐Shin, Eisenberg, Dan, Zhao, Lei, Adams, Christopher, Leib, Ryan, Morser, John, Leung, Lawrence
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2016
• Subjects: Adipocytes; Adipose Tissue - chemistry; Adipose Tissue - metabolism; Adult; Body mass index; Case-Control Studies; Chemokines; Chemokines - analysis; Chemokines - physiology; Diabetes; Female; Gastrointestinal surgery; Humans; Inflammation; Intercellular Signaling Peptides and Proteins - analysis; Intercellular Signaling Peptides and Proteins - physiology; Male; Metabolism; Middle Aged; Obesity; Obesity - blood; Obesity - physiopathology; Omentum - chemistry; Omentum - metabolism; Proteins; Spectrum analysis; Studies; Subcutaneous Fat - chemistry; Subcutaneous Fat - metabolism; Volunteers; Weight control

Objective Chemerin is an inflammatory adipokine, whose activity is regulated by successive proteolytic cleavages at its C‐terminus. It is secreted as an inactive precursor (chem163S); cleavage at Lys158 converts it to chem158K with modest activity. Chem157S is the most potent form and chem155A is in...