Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease
Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation t...
Saved in:
| Published in | Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 12; no. 1 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
John Wiley & Sons, Inc
2020
John Wiley and Sons Inc Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown.
Methods: We determined CSF levels of irisin and brain‐derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ)42, total tau, and Mini‐Mental State Exam (MMSE) scores in a cohort comprising AD patients (n = 14) and non‐demented controls (NDC; n = 25).
Results: CSF irisin correlated positively with BDNF, Aβ42, and MMSE scores, but not with CSF total tau.
Discussion: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD. |
|---|---|
| AbstractList | Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown.
Methods: We determined CSF levels of irisin and brain‐derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ)42, total tau, and Mini‐Mental State Exam (MMSE) scores in a cohort comprising AD patients (n = 14) and non‐demented controls (NDC; n = 25).
Results: CSF irisin correlated positively with BDNF, Aβ42, and MMSE scores, but not with CSF total tau.
Discussion: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD. Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown. Methods: We determined CSF levels of irisin and brain‐derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ) 42 , total tau, and Mini‐Mental State Exam (MMSE) scores in a cohort comprising AD patients ( n = 14) and non‐demented controls (NDC; n = 25). Results: CSF irisin correlated positively with BDNF, Aβ 42 , and MMSE scores, but not with CSF total tau. Discussion: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD. Abstract Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown. Methods: We determined CSF levels of irisin and brain‐derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ)42, total tau, and Mini‐Mental State Exam (MMSE) scores in a cohort comprising AD patients (n = 14) and non‐demented controls (NDC; n = 25). Results: CSF irisin correlated positively with BDNF, Aβ42, and MMSE scores, but not with CSF total tau. Discussion: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD. Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown.Methods: We determined CSF levels of irisin and brain‐derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ)42, total tau, and Mini‐Mental State Exam (MMSE) scores in a cohort comprising AD patients (n = 14) and non‐demented controls (NDC; n = 25).Results: CSF irisin correlated positively with BDNF, Aβ42, and MMSE scores, but not with CSF total tau.Discussion: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD. |
| Author | Ferreira, Sergio T. Drummond, Cláudia Vanderborght, Bart Sudo, Felipe K. Assunção, Naima Tovar‐Moll, Fernanda Ribeiro, Felipe C. Lourenco, Mychael V. Mattos, Paulo De Felice, Fernanda G. |
| AuthorAffiliation | 3 Department of Speech and Hearing Pathology Federal University of Rio de Janeiro Rio de Janeiro Brazil 8 Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro, Rio de Janeiro Rio de Janeiro Brazil 1 Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria – Rio de Janeiro Rio de Janeiro Brazil 5 Institute of Psychiatry, Federal University of Rio de Janeiro Rio de Janeiro Brazil 7 Centre for Neurosciences Studies Queen's University Kingston Ontario Canada 2 D'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil 6 Department of Psychiatry Queen's University Kingston Ontario Canada 4 Institute of Biomedical Sciences Federal University of Rio de Janeiro Rio de Janeiro Brazil |
| AuthorAffiliation_xml | – name: 6 Department of Psychiatry Queen's University Kingston Ontario Canada – name: 5 Institute of Psychiatry, Federal University of Rio de Janeiro Rio de Janeiro Brazil – name: 4 Institute of Biomedical Sciences Federal University of Rio de Janeiro Rio de Janeiro Brazil – name: 7 Centre for Neurosciences Studies Queen's University Kingston Ontario Canada – name: 8 Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro, Rio de Janeiro Rio de Janeiro Brazil – name: 1 Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria – Rio de Janeiro Rio de Janeiro Brazil – name: 2 D'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil – name: 3 Department of Speech and Hearing Pathology Federal University of Rio de Janeiro Rio de Janeiro Brazil |
| Author_xml | – sequence: 1 givenname: Mychael V. surname: Lourenco fullname: Lourenco, Mychael V. organization: Cidade Universitaria – Rio de Janeiro – sequence: 2 givenname: Felipe C. surname: Ribeiro fullname: Ribeiro, Felipe C. organization: Cidade Universitaria – Rio de Janeiro – sequence: 3 givenname: Felipe K. surname: Sudo fullname: Sudo, Felipe K. organization: D'Or Institute for Research and Education (IDOR), Rio de Janeiro – sequence: 4 givenname: Cláudia surname: Drummond fullname: Drummond, Cláudia organization: Federal University of Rio de Janeiro – sequence: 5 givenname: Naima surname: Assunção fullname: Assunção, Naima organization: Federal University of Rio de Janeiro – sequence: 6 givenname: Bart surname: Vanderborght fullname: Vanderborght, Bart organization: D'Or Institute for Research and Education (IDOR), Rio de Janeiro – sequence: 7 givenname: Fernanda surname: Tovar‐Moll fullname: Tovar‐Moll, Fernanda organization: Federal University of Rio de Janeiro – sequence: 8 givenname: Paulo surname: Mattos fullname: Mattos, Paulo organization: Institute of Psychiatry, Federal University of Rio de Janeiro – sequence: 9 givenname: Fernanda G. surname: De Felice fullname: De Felice, Fernanda G. email: felice@bioqmed.ufrj.br organization: Queen's University – sequence: 10 givenname: Sergio T. surname: Ferreira fullname: Ferreira, Sergio T. email: ferreira@bioqmed.ufrj.br organization: Federal University of Rio de Janeiro, Rio de Janeiro |
| BookMark | eNp9kc9uEzEQh1eoiP6hF55gJQ5IqCn22N71XpBCQqFSBRc4W7P2bOJosw72plU48Qh9Fh6Eh-BJcJsK0Qsnj-xvvrHmd1wcDGGgonjB2TlnDN44dHDOgQn5pDgCoWCia2gO_qkPi9OUVowxLhuQnD0rDgUoDVqIo8LOKFIbQ9r4Afuy67felT765IfShhipx5FSeePHZYnrXR-8-_3j9tfPs_Ld_NPFWYmDy9xi8KMPQ5mbpv33Jfk1xVepdD4RJnpePO2wT3T6cJ4UXy_ef5l9nFx9_nA5m15NrFRaTgiaBrG2DWpZ81ZxraGV2OjaQidBtZ2WqgbXMVBNBZJcQxoQOlW3KIDESXG597qAK7OJfo1xZwJ6c38R4sJgHL3tyWhUFjkj6oDLrMKu6nRTSSsAJWmVXW_3rs22XZOzNIwR-0fSxy-DX5pFuDa1YFX-eha8fBDE8G1LaTSrsI15x8lAJZTmmvEqU6_3lM0RpEjd3wmcmbt8zV2-5j7fDPM9fON72v2HNPPpHPY9fwD4pKi5 |
| CitedBy_id | crossref_primary_10_3390_ijms22115795 crossref_primary_10_3389_fnagi_2022_980561 crossref_primary_10_1002_ana_26946 crossref_primary_10_9758_cpn_22_1030 crossref_primary_10_3389_fncel_2022_953991 crossref_primary_10_1002_alz_12757 crossref_primary_10_1523_ENEURO_0256_22_2023 crossref_primary_10_1007_s11914_022_00736_9 crossref_primary_10_1038_s41392_024_01841_0 crossref_primary_10_3389_fnins_2023_1131214 crossref_primary_10_1155_2021_4717349 crossref_primary_10_31189_2165_6193_12_4_111 crossref_primary_10_3390_ijms22041605 crossref_primary_10_3390_ijms23063245 crossref_primary_10_3390_ijms231810388 crossref_primary_10_1002_alz_12893 crossref_primary_10_3390_app11157120 crossref_primary_10_1007_s11011_023_01202_w crossref_primary_10_1007_s00210_023_02726_9 crossref_primary_10_3389_fnagi_2022_965190 crossref_primary_10_3390_ijerph19106153 crossref_primary_10_1007_s12035_023_03490_w crossref_primary_10_3389_fpsyt_2022_967683 crossref_primary_10_1111_jnc_15039 |
| Cites_doi | 10.1038/s41591-018-0275-4 10.1016/j.cmet.2013.09.008 10.1038/nature10777 10.1111/jne.12433 10.1016/j.jalz.2013.12.004 10.1038/nrn4019 10.1073/pnas.1516622112 10.1001/jamaneurol.2019.1879 10.1038/s41591-020-0781-z 10.3389/fnagi.2015.00094 10.1007/s12017-015-8361-y 10.1523/JNEUROSCI.2814-14.2014 10.1111/jnc.13713 10.1016/j.cmet.2015.08.016 10.1016/j.freeradbiomed.2016.04.200 10.18632/aging.102391 10.1016/j.jalz.2017.09.006 10.3233/JAD-179911 |
| ContentType | Journal Article |
| Copyright | 2020 The Authors. published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2020 The Authors. published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association – notice: 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P WIN AAYXX CITATION 3V. 7RV 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. KB0 M0S NAPCQ PIMPY PQEST PQQKQ PQUKI PRINS 5PM DOA |
| DOI | 10.1002/dad2.12034 |
| DatabaseName | Wiley Online Library Open Access Wiley Online Library Free Backfiles CrossRef ProQuest Central (Corporate) Proquest Nursing & Allied Health Source ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) Nursing & Allied Health Premium Publicly Available Content (ProQuest) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central Nursing & Allied Health Premium ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest Central (Alumni) |
| DatabaseTitleList | Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: 7X7 name: ProQuest Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | LOURENCO et al |
| EISSN | 2352-8729 |
| EndPage | n/a |
| ExternalDocumentID | oai_doaj_org_article_8a5ca10eef21424eaf6f8964c32a4e85 10_1002_dad2_12034 DAD212034 |
| Genre | article |
| GrantInformation_xml | – fundername: Alzheimer's Association funderid: AARG‐D‐615741 – fundername: International Society for Neurochemistry – fundername: National Institute for Translational Neuroscience funderid: 465346/2014‐6 – fundername: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro funderid: 202.817/2016; 202.744/2019; 201.432/2014; 202.944/2015 – fundername: Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico funderid: 406436/2016‐9; 434093/2018‐1; 467546/2014‐2 – fundername: ; – fundername: Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico grantid: 406436/2016‐9; 434093/2018‐1; 467546/2014‐2 – fundername: ; grantid: AARG‐D‐615741 – fundername: National Institute for Translational Neuroscience grantid: 465346/2014‐6 – fundername: ; grantid: 202.817/2016; 202.744/2019; 201.432/2014; 202.944/2015 |
| GroupedDBID | 0R~ 0SF 1OC 24P 457 53G 6I. 7RV 7X7 8FI 8FJ AACTN AAEDW AAFTH AAHHS AALRI AAXUO ABMAC ABUWG ACCFJ ACGFS ACXQS ADBBV ADEZE ADKYN ADPDF ADRAZ ADVLN ADZMN ADZOD AEEZP AEQDE AEVXI AEXQZ AFKRA AFTJW AGHFR AITUG AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AMRAJ AOIJS AVUZU BAWUL BENPR CCPQU EBS EJD EMOBN FDB FYUFA GROUPED_DOAJ HMCUK HYE IAO IHR INH KQ8 M48 M~E NAPCQ NCXOZ O9- OK1 OVD OVEED PIMPY ROL RPM SSZ TEORI UKHRP WIN AAYXX CITATION 3V. 7XB 8FK AZQEC DWQXO K9. PQEST PQQKQ PQUKI PRINS 5PM |
| ID | FETCH-LOGICAL-c4584-e299aa7c9a8471b51882b4a987c2f425bf84572df0259624ed9e82a2f57ba32e3 |
| IEDL.DBID | RPM |
| ISSN | 2352-8729 |
| IngestDate | Thu Jul 04 20:48:38 EDT 2024 Tue Sep 17 21:12:44 EDT 2024 Fri Sep 13 01:41:48 EDT 2024 Fri Aug 23 02:17:06 EDT 2024 Sat Aug 24 01:03:13 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Attribution-NonCommercial This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4584-e299aa7c9a8471b51882b4a987c2f425bf84572df0259624ed9e82a2f57ba32e3 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306518/ |
| PMID | 32582833 |
| PQID | 2635818016 |
| PQPubID | 5066178 |
| PageCount | 5 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8a5ca10eef21424eaf6f8964c32a4e85 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7306518 proquest_journals_2635818016 crossref_primary_10_1002_dad2_12034 wiley_primary_10_1002_dad2_12034_DAD212034 |
| PublicationCentury | 2000 |
| PublicationDate | 2020 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – year: 2020 text: 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken |
| PublicationTitle | Alzheimer's & dementia : diagnosis, assessment & disease monitoring |
| PublicationYear | 2020 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2012; 481 2013; 18 2015; 17 2015; 16 2019; 11 2019; 76 2015; 112 2015; 22 2019; 25 2016; 100 2020; 26 2016; 138 2016; 28 2018; 64 2015; 7 2014; 34 2014; 10 2018; 14 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_14_1 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_10_1 e_1_2_8_11_1 e_1_2_8_12_1 |
| References_xml | – volume: 26 start-page: 398 year: 2020 end-page: 407 article-title: A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease publication-title: Nat Med – volume: 100 start-page: 108 year: 2016 end-page: 122 article-title: Energy metabolism and inflammation in brain aging and Alzheimer's disease publication-title: Free Radic Biol Med – volume: 25 start-page: 165 year: 2019 end-page: 175 article-title: Exercise‐linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models publication-title: Nat Med – volume: 76 start-page: 1203 year: 2019 end-page: 1210 article-title: Associations of Physical Activity and beta‐Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults publication-title: JAMA Neurol – volume: 14 start-page: 263 year: 2018 end-page: 270 article-title: Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial publication-title: Alzheimers Dement – volume: 18 start-page: 649 year: 2013 end-page: 659 article-title: Exercise induces hippocampal BDNF through a PGC‐1alpha/FNDC5 pathway publication-title: Cell Metabolism – volume: 28 year: 2016 article-title: Deciphering brain insulin receptor and insulin‐like growth factor 1 receptor signalling publication-title: J Neuroendocrinol – volume: 481 start-page: 463 year: 2012 end-page: 468 article-title: A PGC1‐α‐dependent myokine that drives brown‐fat‐like development of white fat and thermogenesis publication-title: Nature – volume: 17 start-page: 326 year: 2015 end-page: 332 article-title: Lower cerebrospinal fluid concentration of brain‐derived neurotrophic factor predicts progression from mild cognitive impairment to Alzheimer's Disease publication-title: Neuromolecular Med – volume: 112 start-page: 12157 year: 2015 end-page: 12162 article-title: The myokine irisin increases cortical bone mass publication-title: Proc Natl Acad Sci U S A – volume: 11 start-page: 9188 year: 2019 end-page: 9208 article-title: Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum publication-title: Aging – volume: 138 start-page: 785 year: 2016 end-page: 805 article-title: Synaptopathies: synaptic dysfunction in neurological disorders ‐ a review from students to students publication-title: J Neurochem – volume: 64 start-page: 405 year: 2018 end-page: 426 article-title: Metabolic defects in Alzheimer's disease: from basic neurobiology to clinical approaches publication-title: J Alzheimers Dis – volume: 7 start-page: 94 year: 2015 article-title: Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease publication-title: Front Aging Neurosci – volume: 34 start-page: 15139 year: 2014 end-page: 15149 article-title: Exercise, energy intake, glucose homeostasis, and the brain publication-title: J Neurosci – volume: 16 start-page: 660 year: 2015 end-page: 671 article-title: Hippocampal insulin resistance and cognitive dysfunction publication-title: Nat Rev Neurosci – volume: 22 start-page: 761 year: 2015 end-page: 776 article-title: Metabolic and non‐cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology publication-title: Cell Metab – volume: 10 start-page: S26 year: 2014 end-page: S32 article-title: How does brain insulin resistance develop in Alzheimer's disease? publication-title: Alzheimers Dement – ident: e_1_2_8_10_1 doi: 10.1038/s41591-018-0275-4 – ident: e_1_2_8_11_1 doi: 10.1016/j.cmet.2013.09.008 – ident: e_1_2_8_9_1 doi: 10.1038/nature10777 – ident: e_1_2_8_5_1 doi: 10.1111/jne.12433 – ident: e_1_2_8_4_1 doi: 10.1016/j.jalz.2013.12.004 – ident: e_1_2_8_14_1 doi: 10.1038/nrn4019 – ident: e_1_2_8_19_1 doi: 10.1073/pnas.1516622112 – ident: e_1_2_8_16_1 doi: 10.1001/jamaneurol.2019.1879 – ident: e_1_2_8_18_1 doi: 10.1038/s41591-020-0781-z – ident: e_1_2_8_8_1 doi: 10.3389/fnagi.2015.00094 – ident: e_1_2_8_13_1 doi: 10.1007/s12017-015-8361-y – ident: e_1_2_8_15_1 doi: 10.1523/JNEUROSCI.2814-14.2014 – ident: e_1_2_8_7_1 doi: 10.1111/jnc.13713 – ident: e_1_2_8_2_1 doi: 10.1016/j.cmet.2015.08.016 – ident: e_1_2_8_6_1 doi: 10.1016/j.freeradbiomed.2016.04.200 – ident: e_1_2_8_12_1 doi: 10.18632/aging.102391 – ident: e_1_2_8_17_1 doi: 10.1016/j.jalz.2017.09.006 – ident: e_1_2_8_3_1 doi: 10.3233/JAD-179911 |
| SSID | ssj0001492410 |
| Score | 2.4058518 |
| Snippet | Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and... Abstract Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect... |
| SourceID | doaj pubmedcentral proquest crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Publisher |
| SubjectTerms | Alzheimer's disease BDNF Biomarkers Brain-derived neurotrophic factor Cerebrospinal fluid Cerebrospinal Fluid Biomarkers Cognition & reasoning Dementia FNDC5 irisin |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3BTtwwELUQp16qVrTqthRZaiWkisDGcRL7uLBdoR44FYmbNbHHItUSqgUuPfUT-i18CB_BlzDjBLTpob1wi-JEsd_EmTf25I0Qn72JtiFXlEFZx0wHClBsw6tNUAdEkzPL5myLk-r4VH87K8_WSn1xTlgvD9wDd2Cg9JBPESOLg2mEWEVjK-0LBRpNr16al2vB1I-e95Nrmj7pkaqDAEHt52pa6JEHSkL9I3b5d27kOmdNTmfxSrwc2KKc9b18LTaw2xL-CFcUyXLBD26My5s2yJYma9tJz8U2lswfJa-wSriggLwN97__3N3uycP5yWJPQhfkkDV02Um6abb8dY7tBa52r-SwYfNGnC6-fj86zoZaCZnnnc4Mya0A1N4Cu5uGZdZUo8Ga2qtI87KJRpe1CpE4jq0Ix2DRKFCxrBsoFBZvxWZ32eE7IQtdoTZe1WC1hryxxIEwlLkvAAn7aiI-PeLnfvaSGK4XP1aOUXYJ5Yk4ZGifrmAZ63SCjOsG47r_GXcith8N44a5deVYPof_UM-pJ_XIWKOHjVu69jxpZ9MHrSJwJuJLMus_BuDms7lKR--fYygfxAvFoXpavdkWm9erG_xIfOa62Umv7gOw-vUO priority: 102 providerName: Directory of Open Access Journals – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELZKe-GCqAARKJUlkJBQw24cJ7FP1W63qxWHFUJU6s0a22MaaZst2-2FE4_As_AgPARPUk822xIOvUVxIiczHs-vv2HsnVNB26iKUiiqkEofHRRtKdoElUdUGVnZVG0xL2dn8tN5cb7DZtuzMFRWud0T243aLx3FyAcEmkLnkrNyAJaiAG49OL76nlL_KMqzds00HrE9kUlK2O6NT-efv9zHW2T0NLLhHUKpGHjw4mMmhrns6aQWur9nb_5fLfmvFduqoelT9qSzH_low_B9toPNM-ZOcBV9W2oBQoNhcVN7XkfxrRvuqP3GgixKTjFXDpfRRa_935-__vw-4uPJfHrEofG8qyNaNjy-NFr8uMD6Elfvr3mXwnnOzqanX09madc9IXWU-0wxKhqAymkgBWQJeE1YCVpVToQoqTYoWVTCh2j16FJI9BqVABGKykIuMH_Bdptlgy8Zz2WJUjlRgZYSMqujVYS-yFwOWAZVJuztln7magOSYTZwyMIQlU1L5YSNibR3TxCwdXtjufpmOjkxCgoH2RAxEBacRAhxAl1KlwuQqIqEHWwZYzppuzb3ayNhVY9Zvcn6I0190aJpxy2ujMRJ2IeWrQ_8gJmMJqK9evXwV7xmjwW55W2k5oDtrlc3-CbaLmt72C3LW98H8TA priority: 102 providerName: ProQuest – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3BbtQwELVKuXBBIEAsFGQJJCTU0MZxElvisu2yqjhUHKjUmzWxxzTSNlvtthdOfEK_pR_CR_AlzHizu4QDErcotuVkxuN5M7afhXjrTbQNuaIMyjpmOlCAYhvONkEdEE3OKJt3W5xWJ2f683l5viM-rs_CrPghNgk3tow0X7OBQ7M82JKGBgjqQ64OC31P3CdcY3hMK_1lm2HRFFskOgJFKIPMXtkNP6k62DYfeKRE3D9Am3_vlfwTwyYnNH0kHvboUY5X6n4sdrB7IvwxLiiy5QtAuDDObtogWzLetpOeL9-YMZ6UnHGVcEkBeht-_bj9ebcvjyan030JXZD9LqJ5J6nRePb9AttLXLxbyn4B56k4m376enyS9XcnZJ5XPjMkNwNQewvsfhqmXVONBmtqryLZaRONLmsVImEeWymNwaJRoGJZN1AoLJ6J3W7e4XMhC12hNl7VYLWGvLGEiTCUuS8Aq2iqkXizlp-7WlFkuBUZsnIsZZekPBJHLNpNDaa1Ti_mi2-utxJnoPSQHyJGZoLTCJE6sJX2hQKNphyJvbViXG9rS8d0OnxiPacvqQfKGnQ2LOnai8SlTRNcRcIZifdJrf_4ATcZT1R6evE_lV-KB4pD9JS12RO714sbfEU45rp5nYbrb5Nf7kw priority: 102 providerName: Wiley-Blackwell |
| Title | Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdad2.12034 https://www.proquest.com/docview/2635818016/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC7306518 https://doaj.org/article/8a5ca10eef21424eaf6f8964c32a4e85 |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NahsxEBZxeumltKSlblMjSKFQsrZX0q60R__EhEKNKQ34tuhn1Gyx18FJLj31EfosfZA8RJ6kGnkdsj300MuyrHaRdkZivhmNviHkvVW-MMEUJTqTPhEuOCiFwWiTlg5ApYiyMdtinp9fiE_LbHlAsv1ZmJi0b03Vr1frfl1dxtzKq7Ud7PPEBovPE4nlzlM16JCO5PyRi_59B_mDVRo-UJGygdOO9VM25FiEhzPcKOK8ZYciXX8LY_6dIfkYuUbTM3tOnjWYkY52Y3tBDqA-InYC2-DPYtkPbPSr28rRKizZqqYWS26sEEVSjLNSvQ5ueeXuf_66-31Kx9P57JTq2tEmd2hT0_DRaPXjEqo1bD9c02bb5iW5mJ19nZwnTcWExOJ-ZwLBuGgtbaHR6BgkW2NG6EJJy3xYncYrkUnmfEA6Rc4EuAIU08xn0mjOgL8ih_WmhteEcpGDUJZJXQihU1MEJAQuSy3XkHuVd8nJXn7l1Y4Yo9xRILMSBV5GgXfJGEX78AaSWccHm-23slFpqXRmdToE8Mj_JkD70EGRC8uZFqCyLjneK6ZsVth1iSQ6eE49DSORLWW1Omu3hAkVGbSbCdQlH6Na__ED5XQ0ZfHuzX9385Y8Zeilx8DNMTm82d7CuwBlbkyPdJhYhKtcyh55Mj6bL770YligFyf1H4K9-Vg |
| link.rule.ids | 230,315,733,786,790,870,891,2115,4043,11589,12083,21416,27956,27957,27958,31754,33779,43345,43840,46087,46511,50849,50958,53827,53829,74102,74659 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELagHOCCQIAIFLAEEhJq6MZxYvuEtl1WC5Q9tdLeLMcet5G22bLbXnrqI_AsPAgPwZPg8XpbwqG3KD9yMuPxfDOefEPIOyu9aoIryk0lfM5dCFBUg9kmIxyALBBlY7XFtJ4c8a-zapYSbqtUVrlZE-NC7RYWc-S7SJqC_yUX9aezHzl2jcLd1dRC4y65x8uSY0mfmImbHAsP0UUxuGYlZbvOOPaxYIOS9_xQpOvvYcz_KyT_Ra7R9YwfkYcJM9LhWsmPyR3onhC7D8sQz2LbD7zo5xeto20w2bajFltuzBFFUsyzUnMawvLW_bn6-fvXDt0bTcc71HSOptqhRUfDQ8P55Qm0p7B8v6Jp2-YpORp_Ptyf5KljQm5xvzOH4FyMEVYZdDoNkq2xhhslhWU-WGfjJa8Ecz4gHVUzDk6BZIb5SjSmZFA-I1vdooPnhJa8Bi4tE0ZxbopGBSQEripsaaD2ss7I24389NmaGEOvKZCZRinrKOWM7KFor-9AMut4YrE81sk2tDSVNcUAwCP_GwfjwwCq5rZkhoOsMrK9UYxOFrbSN_MhI6KnrN5g_StdexIZtMOyVgfhZORDVOstH6BHwxGLRy9uf4s35P7k8PuBPvgy_faSPGAYlsdMzTbZOl9ewKuAXc6b13GC_gXWMe79 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELagSIgLogJEoFBLICGhht04Tmyf0LbbVfnRigOV9mY59riNtM2W3fbCiUfgWXgQHoInqcfrbQmH3qL8yMmMx_PNePINIW-s9KoJrig3lfA5dyFAUQ1mm4xwALJAlI3VFtP66Jh_mlWzVP-0SmWVmzUxLtRuYTFHPkDSFPwvuagHPpVFfB1PPpx_z7GDFO60pnYad8m94CWH2M1AzMRNvoWHSKMYXjOUsoEzjr0v2LDkPZ8Uqft7ePP_asl_UWx0Q5NH5GHCj3S0Vvg2uQPdY2IPYBliW2wBghf9_LJ1tA3m23bUYvuNOSJKijlXas5CiN66vz9__fm9R_fH08keNZ2jqY5o0dHw0Gj-4xTaM1i-XdG0hfOEHE8Ovx0c5al7Qm5x7zOH4GiMEVYZdEANEq-xhhslhWU-WGrjJa8Ecz6gHlUzDk6BZIb5SjSmZFA-JVvdooNnhJa8Bi4tE0ZxbopGBVQEripsaaD2ss7I64389PmaJEOv6ZCZRinrKOWM7KNor-9AYut4YrE80clOtDSVNcUQwCMXHAfjwwCq5rZkhoOsMrKzUYxO1rbSN3MjI6KnrN5g_StdexrZtMMSVwfhZORdVOstH6DHozGLR89vf4tdcj_MTf3l4_TzC_KAYYQekzY7ZOtieQkvA4y5aF7F-XkFxQ3zKQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cerebrospinal+fluid+irisin+correlates+with+amyloid%E2%80%90%CE%B2%2C+BDNF%2C+and+cognition+in+Alzheimer%27s+disease&rft.jtitle=Alzheimer%27s+%26+dementia+%3A+diagnosis%2C+assessment+%26+disease+monitoring&rft.au=Lourenco%2C+Mychael+V.&rft.au=Ribeiro%2C+Felipe+C.&rft.au=Sudo%2C+Felipe+K.&rft.au=Drummond%2C+Cl%C3%A1udia&rft.date=2020&rft.issn=2352-8729&rft.eissn=2352-8729&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1002%2Fdad2.12034&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_dad2_12034 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-8729&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-8729&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-8729&client=summon |