Pelvic recurrence in stage I seminoma: A new phenomenon that questions modern protocols for radiotherapy and follow-up
Objective: To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para‐aortic template alone. Patients and methods: Over a four‐year period, three patients presented with early pelvic recurrence after radical orchidectomy...
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| Published in | International journal of urology Vol. 12; no. 4; pp. 378 - 382 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Science Pty
01.04.2005
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| Abstract | Objective: To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para‐aortic template alone.
Patients and methods: Over a four‐year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para‐aortic region with omission of the ipsilateral hemi pelvis.
Results: Pelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity.
Conclusion: This significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field. |
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| AbstractList | To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para-aortic template alone.
Over a four-year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para-aortic region with omission of the ipsilateral hemi pelvis.
Pelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity.
This significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field. Objective: To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para‐aortic template alone. Patients and methods: Over a four‐year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para‐aortic region with omission of the ipsilateral hemi pelvis. Results: Pelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity. Conclusion: This significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field. Abstract Objective: To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para‐aortic template alone. Patients and methods: Over a four‐year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para‐aortic region with omission of the ipsilateral hemi pelvis. Results: Pelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity. Conclusion: This significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field. OBJECTIVETo highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para-aortic template alone.PATIENTS AND METHODSOver a four-year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para-aortic region with omission of the ipsilateral hemi pelvis.RESULTSPelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity.CONCLUSIONThis significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field. |
| Author | CROWN, JOHN FRASER, IAN THORNHILL, JOHN A POWER, RICHARD E KENNEDY, JOHN |
| Author_xml | – sequence: 1 givenname: RICHARD E surname: POWER fullname: POWER, RICHARD E organization: Department of Urology, The Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght – sequence: 2 givenname: JOHN surname: KENNEDY fullname: KENNEDY, JOHN organization: St. James's Hospital – sequence: 3 givenname: JOHN surname: CROWN fullname: CROWN, JOHN organization: St. Luke's Hospital, Rathgar, Dublin, Ireland – sequence: 4 givenname: IAN surname: FRASER fullname: FRASER, IAN organization: St. Luke's Hospital, Rathgar, Dublin, Ireland – sequence: 5 givenname: JOHN A surname: THORNHILL fullname: THORNHILL, JOHN A email: richiep@eircom.net organization: Department of Urology, The Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght |
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Phys – volume: 55 start-page: 102 year: 2000 end-page: 106 article-title: Adjuvant treatment of clinical stage 1 seminoma: is a single course of carboplatin sufficient? publication-title: Urology – ident: e_1_2_5_3_2 doi: 10.1016/0360-3016(93)90414-Q – ident: e_1_2_5_18_2 doi: 10.1016/0360-3016(96)00093-4 – ident: e_1_2_5_9_2 doi: 10.1111/j.1464-410X.1987.tb04646.x – ident: e_1_2_5_7_2 doi: 10.1002/1097-0142(19891015)64:8<1608::AID-CNCR2820640809>3.0.CO;2-1 – volume: 80 start-page: 417 year: 1987 ident: e_1_2_5_22_2 article-title: Testicular seminoma in Ireland (1980–85): management, results and prognostic variables publication-title: Ir Med. J. contributor: fullname: Thornhill JA. – volume: 14 start-page: 429 year: 1988 ident: e_1_2_5_23_2 article-title: An evaluation of predisposing factors for testis cancer in Ireland publication-title: Eur. 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Roentgenol. contributor: fullname: Desjandins AU – ident: e_1_2_5_12_2 doi: 10.1016/0959-8049(93)90446-M – ident: e_1_2_5_25_2 doi: 10.1053/clon.2001.9273 – volume: 63 start-page: 37 year: 1991 ident: e_1_2_5_24_2 article-title: A national programme for testis cancer, the Irish Testis Tumour Registry (ITTR) publication-title: Arch. Ital Urol. Nefrol. Androl. contributor: fullname: Thornhill JA – ident: e_1_2_5_15_2 doi: 10.1177/030089169408000212 – ident: e_1_2_5_16_2 doi: 10.1016/0360-3016(93)90954-T – ident: e_1_2_5_20_2 doi: 10.1046/j.1464-410X.2003.04273.x – ident: e_1_2_5_5_2 doi: 10.1016/S0140-6736(51)93202-3 – ident: e_1_2_5_13_2 doi: 10.1200/JCO.2002.01.038 – ident: e_1_2_5_10_2 doi: 10.1016/S0094-0143(05)70032-X |
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| SubjectTerms | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bleomycin - administration & dosage Bleomycin - therapeutic use Cisplatin - administration & dosage Cisplatin - therapeutic use Etoposide - administration & dosage Etoposide - therapeutic use Follow-Up Studies Humans Male Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - epidemiology Neoplasm Staging Orchiectomy Pelvic Neoplasms - diagnostic imaging Pelvic Neoplasms - drug therapy Pelvic Neoplasms - secondary pelvic relapse radiation therapy Radiotherapy, Adjuvant Remission Induction - methods Seminoma - radiotherapy Seminoma - secondary Seminoma - surgery Stage 1 seminoma Testicular Neoplasms - pathology Testicular Neoplasms - radiotherapy Testicular Neoplasms - surgery Tomography, X-Ray Computed |
| Title | Pelvic recurrence in stage I seminoma: A new phenomenon that questions modern protocols for radiotherapy and follow-up |
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