The interplay of cholinergic function, attention, and falls in Parkinson's disease

• Published in: Movement disorders Vol. 26; no. 14; pp. 2496 - 2503
• Main Authors: Yarnall, Alison, Rochester, Lynn, Burn, David J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2011; Wiley
• Subjects: Accidental Falls; Acetylcholine - physiology; attention; Attention - physiology; Biological and medical sciences; cholinergic; Cholinergic Neurons - pathology; Cholinergic Neurons - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dementia; Dementia - pathology; Dementia - physiopathology; falls; Humans; Medical sciences; Neurology; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Nervous system diseases; Parkinson's disease; falls; Central nervous system disease; Attention; cholinergic; Parkinson disease; Degenerative disease; Cerebral disorder; Extrapyramidal syndrome; Dementia

Dopamine loss in the substantia nigra causes several of the motor signs seen in Parkinson's disease, but there is now increasing evidence highlighting the importance of cholinergic loss in the pathophysiology of nonmotor symptoms. The nucleus basalis of Meynert supplies the majority of the chol...