Emerging Insights into the Role of Calcium Ions in Osteoclast Regulation

• Published in: Journal of bone and mineral research Vol. 14; no. 5; pp. 669 - 674
• Main Authors: Zaidi, Mone, Adebanjo, Olugbenga A., Moonga, Baljit S., Sun, Li, Huang, Christopher L.‐H.
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.05.1999; American Society for Bone and Mineral Research
• Subjects: Animals; Biological and medical sciences; Calcitonin - physiology; Calcium - physiology; Fundamental and applied biological sciences. Psychology; Humans; Hydrogen-Ion Concentration; Interleukin-6 - physiology; Membrane Potentials; Osteoclasts - physiology; Signal Transduction; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; Osteoarticular system; Signal transduction; Regulation(control); Calcium ion; Cell death; Resorption; Osteoclast; Bone; Gene expression; Extracellular; Apoptosis

Osteoclasts are exposed to unusually high, millimolar, Ca2+ concentrations and can “sense” changes in their ambient Ca2+ concentration during resorption. This results in a sharp cystolic Ca2+ increase through both Ca2+ release and Ca2+ influx. The rise in cystolic Ca2+ is transduced finally into an...