Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular Cells - Sanada, Fumihiro; Kanbara, Yasuhiro; Taniyama, Yoshiaki; Otsu, Rei; Carracedo, Miguel; Ikeda-Iwabu, Yuka; Muratsu, Jun; Sugimoto, Ken; Yamamoto, Koichi; Rakugi, Hiromi; Morishita, Ryuichi (Arteriosclerosis, thrombosis, and vascular biology, 2016)
Keywords: Angiogenesis Inducing Agents - pharmacology; Angiopoietin-1 - metabolism; Animals; Capillaries - drug effects; Capillaries - enzymology; Capillaries - physiopathology; Cells, Cultured; Cyclic AMP - metabolism; Disease Models, Animal; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; Hindlimb; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - enzymology; Ischemia - drug therapy; Ischemia - enzymology; Ischemia - genetics; Ischemia - physiopathology; Mice, Inbred C57BL; Muscle, Skeletal - blood supply; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - enzymology; Neovascularization, Physiologic - drug effects; Phosphodiesterase 3 Inhibitors - pharmacology; PPAR gamma - agonists; PPAR gamma - metabolism; Rats; Second Messenger Systems; Tetrazoles - pharmacology; Time Factors; Transfection; Vascular Endothelial Growth Factor A - metabolism; cilostazol; peripheral arterial disease; muscle development; angiogenesis effect; hepatocyte growth factor; intermittent claudication