NOVEL PS-OME MIRNA130B-3P REDUCES INFLAMMATION AND INJURY AND IMPROVES SURVIVAL AFTER RENAL ISCHEMIA-REPERFUSION INJURY

• Published in: Shock (Augusta, Ga.) Vol. 60; no. 4; p. 613
• Main Authors: Vazquez, Gustavo, Sfakianos, Maria, Coppa, Gene, Jacob, Asha, Wang, Ping
• Format: Journal Article
• Language: English
• Published: United States 01.10.2023
• Subjects: Acute Kidney Injury - genetics; Acute Kidney Injury - therapy; Animals; Inflammation - metabolism; Ischemia - metabolism; Kidney - metabolism; Lipocalin-2; Male; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; Reperfusion Injury - metabolism

Introduction : Acute kidney injury (AKI) is a prevalent medical disorder characterized by a sudden decline in kidney function, often because of ischemia/reperfusion (I/R) events. It is associated with significant chronic complications, and currently available therapies are limited to supportive meas...