Removal of milk by suckling acutely increases the prolactin receptor gene expression in the lactating mouse mammary gland

• Published in: Molecular and cellular endocrinology Vol. 131; no. 1; pp. 31 - 38
• Main Authors: Kim, Jae Young, Mizoguchi, Yasushi, Yamaguchi, Hirohito, Enami, Jumpei, Sakai, Senkiti
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 04.07.1997
• Subjects: Animals; Animals, Suckling; Female; Gene expression; Gene Expression Regulation - physiology; Lactation - genetics; Lactation - metabolism; Mammary Glands, Animal - chemistry; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - physiology; Mice; Mice, Inbred ICR; Milk; Milk - metabolism; Polymerase Chain Reaction; Prolactin receptor; Receptors, Prolactin - genetics; Receptors, Prolactin - physiology; RNA, Messenger - metabolism; Suckling; Time Factors; Weaning; Suckling; Prolactin receptor; Gene expression; Milk

To determine the effect of suckling on the prolactin receptor (PRL-R) gene expression, we measured the quantity of PRL-R mRNA in the lactating mouse mammary gland. When the pups were separated from their mother on day 5 of lactation, the long form of PRL-R (PRL-R L) mRNA disappeared with a half-life...