Cell-derived vesicles exposing coagulant tissue factor in saliva

• Published in: Blood Vol. 117; no. 11; pp. 3172 - 3180
• Main Authors: Berckmans, René J., Sturk, Auguste, van Tienen, Laurens M., Schaap, Marianne C.L., Nieuwland, Rienk
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 17.03.2011; Americain Society of Hematology
• Subjects: Adult; Biological and medical sciences; Blood Coagulation; Cell-Derived Microparticles - metabolism; Cell-Derived Microparticles - ultrastructure; Coagulants - metabolism; Exosomes - metabolism; Exosomes - ultrastructure; Factor VII - metabolism; Female; Fibrinogen - metabolism; Hematologic and hematopoietic diseases; Humans; Male; Medical sciences; Saliva - metabolism; Thromboplastin - metabolism; Coagulant; Vesicle; Hematology; Saliva; Tissue factor

On vascular damage, coagulation is initiated by extravascular tissue factor (TF). Intravascular TF, which is present on circulating cell-derived vesicles, is noncoagulant under physiologic conditions but prothrombotic under pathologic conditions. Human saliva triggers coagulation, but the mechanism...