Biophysical and Biochemical Characterization of TP0037, a d -Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum

• Published in: mBio Vol. 11; no. 5
• Main Authors: Deka, Ranjit K., Liu, Wei Z., Norgard, Michael V., Brautigam, Chad A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 22.09.2020
• Subjects: acetogenesis; BASIC BIOLOGICAL SCIENCES; d-lactate dehydrogenase; Host-Microbe Biology; spirochetes; Treponema pallidum; X-ray crystallography

Because T. pallidum lacks a Krebs cycle and the capability for oxidative phosphorylation, historically it has been difficult to reconcile how the syphilis spirochete generates sufficient ATP to fulfill its energy needs, particularly for its robust motility, solely from glycolysis. We have postulated...