Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats

• Published in: Neuropharmacology Vol. 86; pp. 389 - 396
• Main Authors: Yin, Qingqing, Ma, Yingjuan, Hong, Yan, Hou, Xunyao, Chen, Jian, Shen, Chao, Sun, Menghan, Shang, Yuying, Dong, Siqin, Zeng, Ziling, Pei, Jin-Jing, Liu, Xueping
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2014
• Subjects: Animals; Antioxidants - metabolism; Carotenoids - pharmacology; Cerebral Cortex - drug effects; Cerebral Cortex - physiopathology; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - physiopathology; Cognitive deficits; Cytokines - metabolism; Drinking; Fructose - administration & dosage; Fructose - toxicity; Hippocampus - drug effects; Hippocampus - physiopathology; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Lycopene; Male; Medicin och hälsovetenskap; Memory Disorders - drug therapy; Memory Disorders - etiology; Memory Disorders - physiopathology; Neuroimmunomodulation - drug effects; Neuroimmunomodulation - physiology; Neuroinflammation; Nootropic Agents - pharmacology; Oxidative damage; Oxidative Stress - drug effects; Oxidative Stress - physiology; Random Allocation; Rats, Wistar; Sweetening Agents - administration & dosage; Sweetening Agents - toxicity; Insulin resistance; Neuroinflammation; Oxidative damage; Cognitive deficits; Lycopene

Fructose intake is linked with the increasing prevalence of insulin resistance, and insulin resistance links Alzheimer's disease with impaired insulin signaling, oxidative damage, neuroinflammation, and cognitive impairment. As a member of the carotenoid family of phytochemicals, lycopene is us...