Etanercept (Enbrel®) therapy for chronic inflammatory demyelinating polyneuropathy
Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and/or variants who were refractory or intolerant of standard therapies were treated with etanercept, 25 mg twice per week. Ten patients underwent treatment, and manual muscle strength, sensory thresholds and functional abilities...
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Published in | Journal of the neurological sciences Vol. 210; no. 1; pp. 19 - 21 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
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Elsevier B.V
15.06.2003
Elsevier Science |
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Abstract | Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and/or variants who were refractory or intolerant of standard therapies were treated with etanercept, 25 mg twice per week. Ten patients underwent treatment, and manual muscle strength, sensory thresholds and functional abilities were tested prior to and 4–6 months after initiating therapy. Three patients had significant improvement and three others had possible improvement. Based on these preliminary observations, treatment with etanercept may be considered in patients with CIDP, who cannot undergo standard therapies, although its efficacy in CIDP needs to be examined in a double-blinded, controlled clinical trial. |
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AbstractList | Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and/or variants who were refractory or intolerant of standard therapies were treated with etanercept, 25 mg twice per week. Ten patients underwent treatment, and manual muscle strength, sensory thresholds and functional abilities were tested prior to and 4–6 months after initiating therapy. Three patients had significant improvement and three others had possible improvement. Based on these preliminary observations, treatment with etanercept may be considered in patients with CIDP, who cannot undergo standard therapies, although its efficacy in CIDP needs to be examined in a double-blinded, controlled clinical trial. |
Author | Sherman, William H Latov, Norman Hays, Arthur P Sander, Howard W Chin, Russell L |
Author_xml | – sequence: 1 givenname: Russell L surname: Chin fullname: Chin, Russell L email: ruc9002@med.cornell.edu organization: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA – sequence: 2 givenname: William H surname: Sherman fullname: Sherman, William H organization: Department of Medicine, Columbia University, New York, NY, USA – sequence: 3 givenname: Howard W surname: Sander fullname: Sander, Howard W organization: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA – sequence: 4 givenname: Arthur P surname: Hays fullname: Hays, Arthur P organization: Department of Pathology, Columbia University, New York, NY, USA – sequence: 5 givenname: Norman surname: Latov fullname: Latov, Norman organization: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA |
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Keywords | Therapy Tumor necrosis factor (TNF) Polyneuropathy Etanercept (Enbrel®) Demyelination Chronic inflammatory demyelinating polyneuropathy (CIDP) Human Nervous system diseases Cytokine Inflammatory disease Case study Chemotherapy Chronic Treatment Etanercept Peripheral nerve disease Antagonist Tumor necrosis factor α |
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SubjectTerms | Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Chronic inflammatory demyelinating polyneuropathy (CIDP) Combined Modality Therapy Demyelination Drug Administration Schedule Etanercept Etanercept (Enbrel®) Female Humans Immunoglobulin G - therapeutic use Immunomodulators Male Medical sciences Middle Aged Movement - physiology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Muscle, Skeletal - drug effects Muscle, Skeletal - physiopathology Neural Conduction Neurology Pharmacology. Drug treatments Polyneuropathy Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - drug therapy Receptors, Tumor Necrosis Factor - therapeutic use Therapy Treatment Outcome Tumor necrosis factor (TNF) |
Title | Etanercept (Enbrel®) therapy for chronic inflammatory demyelinating polyneuropathy |
URI | https://dx.doi.org/10.1016/S0022-510X(03)00010-8 https://www.ncbi.nlm.nih.gov/pubmed/12736082 https://search.proquest.com/docview/73263511 |
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