Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium

• Published in: Journal of the American Society of Hypertension Vol. 2; no. 6; pp. 439 - 447
• Main Authors: Carneiro, Fernando S., MSc, Carneiro, Zidonia N, Giachini, Fernanda R.C., MSc, Lima, Victor V., BSc, Nogueira, Edson F., MD, Rainey, William E., PhD, Tostes, Rita C., PhD, Webb, R. Clinton, PhD
• Format: Journal Article
• Language: English
• Published: United States 01.11.2008
• Subjects: Cardiovascular; DOCA-salt hypertension; ET A receptor; erectile dysfunction; corpus cavernosum

Abstract Endothelin-1 (ET-1) and urotensin-II (U-II) are the most potent constrictors of human vessels. Although the cavernosal tissue is highly responsive to ET-1, no information exists on the effects of U-II on cavernosal function. The aim of this study was to characterize ET-1 and U-II responses...