Surrogate end points for pulmonary arterial hypertension

• Published in: The American heart journal Vol. 148; no. 4; pp. 559 - 565
• Main Authors: Kawut, Steven M., Palevsky, Harold I.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2004; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Biomarkers - blood; Clinical trials; Disease; Drug therapy; Echocardiography; Exercise Test; FDA approval; Hemodynamics; Humans; Hypertension; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - therapy; Medical sciences; Neurotransmitter Agents - blood; Outcome Assessment (Health Care) - methods; Pneumology; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Quality of life; Regulatory approval; Studies; Cardiovascular disease; End; Respiratory disease; Artery; Pulmonary hypertension

Pulmonary arterial hypertension is a rare disease that is characterized by increased pulmonary vascular resistance and right heart failure. Recent advances in the understanding of pulmonary arterial hypertension have been translated into effective therapies tested in clinical trials. These trials ha...