The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze

• Published in: European journal of pharmacology Vol. 476; no. 3; pp. 193 - 199
• Main Authors: Guscott, Martin R., Clarke, Hannah F., Murray, Fraser, Grimwood, Sarah, Bristow, Linda J., Hutson, Peter H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 29.08.2003; Elsevier
• Subjects: Administration, Oral; Animals; Behavior, Animal - drug effects; Behavioral psychophysiology; Biological and medical sciences; CP-101,606; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Fundamental and applied biological sciences. Psychology; Hippocampus - metabolism; Hippocampus - physiology; Injections, Intraperitoneal; Male; Maze Learning - drug effects; Memory - drug effects; Memory - physiology; Morris watermaze; Neurotransmission and behavior; NMDA receptor NR2B subunit selective antagonist; Piperidines - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Radioligand Assay; Rat; Rats; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Swimming; CP-101,606; Rat; Morris watermaze; NMDA receptor NR2B subunit selective antagonist; Rodentia; Cognition; Learning; Vertebrata; Mammalia; Animal; Antagonist; NMDA receptor; Spatial memory

It is well established that the NMDA receptor antagonists block hippocampal long-term potentiation and impair acquisition in the Morris watermaze task, although the role of individual NMDA receptor subtypes is largely unknown. In the present study, we compared the effects of (±)-CP-101,606, an antag...