Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits
Rabbits were fed Moringa oleifera (200 mg/kg/day, p.o.) or lovastatin (6 mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days. Moringa oleifera and lovastatin were found to lower the serum cholesterol, phospholipid, triglyceride, VLDL, LDL,...
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| Published in | Journal of ethnopharmacology Vol. 86; no. 2; pp. 191 - 195 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
01.06.2003
Elsevier |
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| Online Access | Get full text |
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| Abstract | Rabbits were fed
Moringa oleifera (200
mg/kg/day, p.o.) or lovastatin (6
mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days.
Moringa oleifera and lovastatin were found to lower the serum cholesterol, phospholipid, triglyceride, VLDL, LDL, cholesterol to phospholipid ratio and atherogenic index, but were found to increase the HDL ratio (HDL/HDL-total cholesterol) as compared to the corresponding control groups. Treatment with
M. oleifera or lovastatin in normal rabbits decreased the HDL levels. However, HDL levels were significantly increased or decreased in
M. oleifera- or lovastatin-treated hypercholesterolaemic rabbits, respectively. Lovastatin- or
M. oleifera-treated hypercholesterolaemic rabbits showed decrease in lipid profile of liver, heart and aorta while similar treatment of normal animals did not produce significant reduction in heart.
Moringa oleifera was found to increase the excretion of faecal cholesterol. Thus, the study demonstrates that
M. oleifera possesses a hypolipidaemic effect. |
|---|---|
| AbstractList | Rabbits were fed
Moringa oleifera (200
mg/kg/day, p.o.) or lovastatin (6
mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days.
Moringa oleifera and lovastatin were found to lower the serum cholesterol, phospholipid, triglyceride, VLDL, LDL, cholesterol to phospholipid ratio and atherogenic index, but were found to increase the HDL ratio (HDL/HDL-total cholesterol) as compared to the corresponding control groups. Treatment with
M. oleifera or lovastatin in normal rabbits decreased the HDL levels. However, HDL levels were significantly increased or decreased in
M. oleifera- or lovastatin-treated hypercholesterolaemic rabbits, respectively. Lovastatin- or
M. oleifera-treated hypercholesterolaemic rabbits showed decrease in lipid profile of liver, heart and aorta while similar treatment of normal animals did not produce significant reduction in heart.
Moringa oleifera was found to increase the excretion of faecal cholesterol. Thus, the study demonstrates that
M. oleifera possesses a hypolipidaemic effect. Rabbits were fed Moringa oleifera (200mg/kg/day, p.o.) or lovastatin (6mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and hypercholesterolaemic diet for 120 days. Moringa oleifera and lovastatin were found to lower the serum cholesterol, phospholipid, triglyceride, VLDL, LDL, cholesterol to phospholipid ratio and atherogenic index, but were found to increase the HDL ratio (HDL/HDL-total cholesterol) as compared to the corresponding control groups. Treatment with M. oleifera or lovastatin in normal rabbits decreased the HDL levels. However, HDL levels were significantly increased or decreased in M. oleifera- or lovastatin-treated hypercholesterolaemic rabbits, respectively. Lovastatin- or M. oleifera-treated hypercholesterolaemic rabbits showed decrease in lipid profile of liver, heart and aorta while similar treatment of normal animals did not produce significant reduction in heart. Moringa oleifera was found to increase the excretion of faecal cholesterol. Thus, the study demonstrates that M. oleifera possesses a hypolipidaemic effect. |
| Author | Amin, A.H. Bafna, P.A. Gulati, O.D. Mehta, Komal Balaraman, R. |
| Author_xml | – sequence: 1 givenname: Komal surname: Mehta fullname: Mehta, Komal organization: Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kalabhavan, Baroda 390 001, Gujarat, India – sequence: 2 givenname: R. surname: Balaraman fullname: Balaraman, R. email: rbalaraman@satyam.net.in organization: Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kalabhavan, Baroda 390 001, Gujarat, India – sequence: 3 givenname: A.H. surname: Amin fullname: Amin, A.H. organization: Alembic Ltd., Baroda, Gujarat, India – sequence: 4 givenname: P.A. surname: Bafna fullname: Bafna, P.A. organization: Department of Pharmacy, Faculty of Technology and Engineering, The M.S. University of Baroda, Kalabhavan, Baroda 390 001, Gujarat, India – sequence: 5 givenname: O.D. surname: Gulati fullname: Gulati, O.D. organization: Ambalal Sarabhai Enterprises, Baroda 390 007, Gujarat, India |
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| Cites_doi | 10.1111/j.1471-4159.1965.tb10256.x 10.1093/clinchem/18.7.673 10.1016/S0022-2275(20)43088-3 10.1172/JCI106102 10.1016/S0021-9258(18)64849-5 10.1055/s-2006-957414 10.1016/S0378-8741(99)00106-3 10.1016/0021-9150(77)90180-0 |
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| Keywords | Hypolipidaemic effect Lovastatin Moringa oleifera Cholesterol Prevention of atherosclerosis Rabbit Phospholipid Medicinal plant Dicotyledones Angiospermae Atherosclerosis Moringaceae Phytotherapy Fruit Oral administration Lagomorpha Triglyceride Biological activity Vertebrata Mammalia Treatment Animal Plant origin Spermatophyta Antilipemic agent |
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| Snippet | Rabbits were fed
Moringa oleifera (200
mg/kg/day, p.o.) or lovastatin (6
mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and... Rabbits were fed Moringa oleifera (200mg/kg/day, p.o.) or lovastatin (6mg/kg/day, p.o.) in banana pulp along with standard laboratory diet and... |
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| SubjectTerms | Animals Biological and medical sciences Cholesterol Cholesterol, HDL - blood Fruit General pharmacology Hypercholesterolemia - diet therapy Hypercholesterolemia - drug therapy Hypolipidaemic effect Hypolipidemic Agents - therapeutic use Lipids - blood Lovastatin Lovastatin - therapeutic use Male Medical sciences Moringa oleifera Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Preparations - therapeutic use Prevention of atherosclerosis Rabbits |
| Title | Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits |
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