In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives - Shao, Jing-Wei; Dai, Yong-Chao; Xue, Jin-Ping; Wang, Ji-Chuang; Lin, Feng-Ping; Guo, Yang-Hao (European journal of medicinal chemistry, 2011)
Keywords: Animals; Anticancer activity; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Caspase 3 - genetics; Caspase 3 - metabolism; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemistry, Medicinal; Crystallography, X-Ray; Cytotoxicity; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Expression - drug effects; General aspects; HeLa Cells; Hep G2 Cells; Humans; Life Sciences & Biomedicine; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Medical sciences; Mice; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; Synthesis; Triterpenes - chemical synthesis; Triterpenes - pharmacology; Ursolic Acid; Ursolic acid derivatives; Xenograft Model Antitumor Assays; Cytotoxicity; Ursolic acid derivatives; Synthesis; Anticancer activity; Apoptosis; CELLS; ACTIVATION; DOWN-REGULATION; AGENTS; CYTOTOXIC ACTIVITY; Antineoplastic agent; Pentacyclic compound; Intraperitoneal administration; Liver; Hepatic disease; Hepatocellular carcinoma; Hepatocyte; Structure activity relation; Secondary alcohol; Mechanism of action; Chemical synthesis; Acylate; Antimitotic; Tumor cell; Human; Ursane derivatives; Terpenoid; Rodentia; Malignant tumor; In vitro; Primary alcohol; In vivo; Vertebrata; Chemotherapy; Mammalia; Treatment; Cell line; Mouse; Animal; Triterpene; Digestive diseases; Cancer