Optimization of a pressurized liquid extraction method by experimental design methodologies for the determination of fluoroquinolone residues in infant foods by liquid chromatography

• Published in: Journal of Chromatography A Vol. 1217; no. 5; pp. 605 - 613
• Main Authors: Rodriguez, E., Villoslada, F. Navarro, Moreno-Bondi, M.C., Marazuela, M.D.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 29.01.2010; Elsevier
• Subjects: Acetonitriles - chemistry; Analysis of Variance; Antibacterials; Biological and medical sciences; Chemical Fractionation - methods; Chromatography, Liquid - methods; Experimental design; Fluoroquinolones; Fluoroquinolones - analysis; Food industries; Fundamental and applied biological sciences. Psychology; Infant Food - analysis; Infant foods; LC-FLD; Models, Chemical; Pressure; Pressurized liquid extraction; Reproducibility of Results; Research and development. New food products, dietetic foods and beverages; Sensitivity and Specificity; Tandem Mass Spectrometry - methods; Temperature; Fluoroquinolones; Pressurized liquid extraction; Antibacterials; Experimental design; Infant foods; LC-FLD; Fluorescence detector; Chemical analysis; HPLC chromatography; Solvent extraction; Veterinary medicine; Contamination; Optimization; Operating conditions; Fluoroquinolone derivatives; Pressure effect; Sample preparation; Residue; Infant food; Antibacterial agent; Factorial design; Chemometrics; Quantitative analysis

In the present study, we have developed a method based on pressurized liquid extraction (PLE) and liquid chromatography with fluorescence detection (LC-FLD) for the determination of residues of fluoroquinolones (FQs) in infant food products. PLE extraction has been optimized by the application of ex...