Orally Ingested Human Lactoferrin Is Digested and Secreted in the Upper Gastrointestinal Tract In Vivo in Women with Ileostomies

• Published in: The Journal of nutrition Vol. 132; no. 9; pp. 2597 - 2600
• Main Authors: Troost, Freddy J., Saris, Wim H.M., Brummer, Robert-Jan M.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.09.2002; American Society for Nutritional Sciences; American Institute of Nutrition
• Subjects: Administration, Oral; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Beverages; Biological and medical sciences; breakdown; colon; Digestion; Digestive system; digestive system diseases; Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery; Enzyme-Linked Immunosorbent Assay; excretion; Female; Gastrointestinal Transit; glycoproteins; Humans; Ileostomy; ileum; inflammation; ingredients; Intensive care medicine; lactoferrin; Lactoferrin - administration & dosage; Lactoferrin - metabolism; Lactoferrin - secretion; Medical sciences; Metabolism; Middle Aged; milk; nutrition; oral administration; oxidative stress; patients; Pilot Projects; Recombinant Proteins - administration & dosage; Recombinant Proteins - metabolism; Small intestine; survival rate; Women; GI; rhLF; breakdown; ileostomy; lactoferrin; digestion; small intestine; IBD; LF; TNF; Human; Human origin; Ileostomy; Pathophysiology; Digestive system; Supplemented diet; Digestion; Small intestine; Survival; Feeding; Lactoferrin; Surgery; Female; Colon; Recombinant protein

Lactoferrin (LF), a glycoprotein present in milk and other secretions, may provide a nutritional ingredient for the treatment of intestinal disorders associated with hyperpermeability, oxidative stress and inflammation. The aim of the study was to determine the survival rate of orally administered r...