A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis

• Published in: American journal of respiratory cell and molecular biology Vol. 52; no. 2; pp. 217 - 231
• Main Authors: Bauer, Yasmina, Tedrow, John, de Bernard, Simon, Birker-Robaczewska, Magdalena, Gibson, Kevin F., Guardela, Brenda Juan, Hess, Patrick, Klenk, Axel, Lindell, Kathleen O., Poirey, Sylvie, Renault, Bérengère, Rey, Markus, Weber, Edgar, Nayler, Oliver, Kaminski, Naftali
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2015
• Subjects: Animals; Biopsy; Bleomycin - metabolism; Disease Models, Animal; Epithelial Cells - metabolism; Epithelial Cells - pathology; Extracellular matrix; Fibroblasts - metabolism; Gene expression; Gene Expression - physiology; Genomics; Humans; Idiopathic Pulmonary Fibrosis - genetics; Lung - metabolism; Lung - pathology; Lung diseases; Mortality; Original Research; Principal components analysis; Protein Biosynthesis; Pulmonary fibrosis; Rats, Sprague-Dawley; Rodents; Signal Transduction - genetics; genomics; animal model; lung fibrosis; biomarkers

The bleomycin-induced rodent lung fibrosis model is commonly used to study mechanisms of lung fibrosis and to test potential therapeutic interventions, despite the well recognized dissimilarities to human idiopathic pulmonary fibrosis (IPF). Therefore, in this study, we sought to identify genomic co...