Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide

• Published in: Archives of pharmacal research Vol. 43; no. 11; pp. 1207 - 1213
• Main Authors: Bae, Jung-Woo, Oh, Kyung-Yul, Yoon, So-Jung, Shin, Hyo-Bin, Jung, Eui Hyun, Cho, Chang-Keun, Lim, Chang Woo, Kang, Pureum, Choi, Chang-Ik, Jang, Choon-Gon, Lee, Seok-Yong, Lee, Yun Jeong
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.11.2020; 대한약학회
• Subjects: gastrointestinal system; genetic polymorphism; genotype; genotyping; Medicine; metoclopramide; oral administration; pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Research Article; 약학; Genotype; Pharmacokinetics; CYP2D6; Metoclopramide; Genetic polymorphism

Metoclopramide inhibits the central and peripheral D 2 receptors and is frequently prescribed in adults and children as an antiemetic or a prokinetic drug to control symptoms of upper gastrointestinal motor disorders. Metoclopramide is predominantly metabolized via N-dealkylation and it is primarily...