Diagnostic Value of Alcohol Dehydrogenase (ADH) Isoenzymes and Aldehyde Dehydrogenase (ALDH) Measurement in the Sera of Colorectal Cancer Patients

• Published in: Digestive diseases and sciences Vol. 55; no. 10; pp. 2953 - 2957
• Main Authors: Jelski, Wojciech, Mroczko, Barbara, Szmitkowski, Maciej
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Aged; Alcohol Dehydrogenase - blood; Aldehyde Dehydrogenase - blood; Biochemistry; Biological and medical sciences; Biomarkers - blood; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - metabolism; Feeding. Feeding behavior; Female; Fluorometry; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Isoenzymes - blood; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplant Surgery; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Alcohol dehydrogenase isoenzymes; Aldehyde dehydrogenase; Colorectal cancer; Human; Rectal disease; Enzyme; Metabolic diseases; Malignant tumor; Alcohol dehydrogenase; Aldehyde; Dehydrogenase; Colonic disease; Gastroenterology; Digestive diseases; Intestinal disease; Serum; Oxidoreductases; Diagnosis; Cancer

Background The activity of total alcohol dehydrogenase (ADH) and class I isoenzymes is significantly higher in colorectal cancer tissue than in healthy mucosa. The activity of these enzymes in cancer cells is probably reflected in the sera and could thus be helpful for diagnosing colorectal cancer....