Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 21; pp. 8791 - 8796
• Main Authors: Li, Da-Qiang, Pakala, Suresh B., Reddy, Sirigiri Divijendra Natha, Ohshiro, Kazufumi, Zhang, Jun-Xiang, Wang, Lei, Zhang, Yanping, de Alborán, Ignacio Moreno, Pillai, M. Radhakrishna, Eswaran, Jeyanthy, Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.05.2011; National Acad Sciences
• Subjects: adenosinetriphosphatase; Antibodies; Biological Sciences; Cancer; carcinogenesis; Cell Line; Cells; Cyclin-Dependent Kinase Inhibitor p16 - antagonists & inhibitors; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; DNA; Down regulation; Epithelial cells; Gene Expression Regulation; Genes; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; histones; Homeostasis; Homeostasis - genetics; Humans; Metastasis; neoplasms; Neoplasms - etiology; nucleosomes; nucleotide sequences; Promoter regions; proteasome endopeptidase complex; Proteins; Reading Frames; Repressor Proteins - antagonists & inhibitors; Repressor Proteins - genetics; Repressor Proteins - metabolism; signal transduction; Trans-Activators; Transcription factors; Transcriptional Activation; Tumor Suppressor Protein p53; Tumors

Although metastasis-associated protein 1 (MTA1), a component of the nucleosome remodeling and histone deacetylation complex, is widely up-regulated in human cancers and correlates with tumor metastasis, its regulatory mechanism and related signaling pathways remain unknown. Here, we report a previou...