Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro

• Published in: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Vol. 619; no. 1-2; pp. 45 - 58
• Main Authors: Papageorgiou, Iraklis, Yin, Zhirong, Ladon, Dariusz, Baird, Duncan, Lewis, Andrew C, Sood, Aman, Newson, Roger, Learmonth, Ian D, Case, Charles Patrick
• Format: Journal Article
• Language: English
• Published: Netherlands 01.06.2007
• Subjects: Apoptosis - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Cells, Cultured; Cellular Senescence - drug effects; Cellular Senescence - genetics; Chromium Alloys - toxicity; Chromosome Aberrations - chemically induced; Chromosome Painting; Cytogenetics; DNA Damage; Gene Expression - drug effects; Humans; In Vitro Techniques; Mitochondria - drug effects; Mitochondria - metabolism; Mutagens - toxicity; Reverse Transcriptase Polymerase Chain Reaction

Humans are exposed to metals from industry, the environment and from wear debris from worn orthopaedic joint replacements. Patients exposed to worn cobalt chrome hip replacements show an increase of chromosome aberrations in the bone marrow adjacent to the implant and an increase of chromosome trans...