Expression of heat shock protein 27 correlates with actin cytoskeletal dynamics and contractility of cultured human bladder smooth muscle cells

• Published in: Experimental cell research Vol. 338; no. 1; pp. 39 - 44
• Main Authors: Wang, Yongquan, Xiong, Zhiyong, Gong, Wei, Zhou, Peng, Xie, Qiubo, Zhou, Zhansong, Lu, Gensheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2015; Elsevier BV
• Subjects: Actin cytoskeleton; Actin Cytoskeleton - metabolism; Bladder smooth muscle cells; Contraction; Gene Expression; HEK293 Cells; HSP27; HSP27 Heat-Shock Proteins - genetics; HSP27 Heat-Shock Proteins - metabolism; Humans; Muscle Contraction; Myocytes, Smooth Muscle - physiology; Urinary Bladder - cytology; Actin cytoskeleton; Bladder smooth muscle cells; Contraction; HSP27

Heat shock protein 27 (HSP27) is one of the most important chaperone proteins that modulates smooth muscle contraction. Here we investigated the effects of HSP27 expression on cytoskeleton dynamics and contractile function of human bladder smooth muscle cells (BSMCs) in vitro. Cultured human BSMCs w...