A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Background: In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is...
Saved in:
Published in | Current biology Vol. 9; no. 1; pp. 1 - 10 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Inc
14.01.1999
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2–M DNA-damage checkpoint.
Results: Here, we show that the activity of Cdc25 decreased following exposure to ionizing radiation. The irradiation-induced decrease in Cdc25 activity was suppressed by wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinases, and was dependent on the function of the gene that is mutated in ataxia telangiectasia. We also identified two human kinases that phosphorylate and inactivate Cdc25 in vitro. One is the previously characterized Chk1 kinase. The second is novel and is homologous to the Cds1/Rad53 family of checkpoint kinases in yeast. Human Cds1 was found to be activated in response to DNA damage.
Conclusions: These results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1. |
---|---|
AbstractList | In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2-M DNA-damage checkpoint.
Here, we show that the activity of Cdc25 decreased following exposure to ionizing radiation. The irradiation-induced decrease in Cdc25 activity was suppressed by wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinases, and was dependent on the function of the gene that is mutated in ataxia telangiectasia. We also identified two human kinases that phosphorylate and inactivate Cdc25 in vitro. One is the previously characterized Chk1 kinase. The second is novel and is homologous to the Cds1/Rad53 family of checkpoint kinases in yeast. Human Cds1 was found to be activated in response to DNA damage.
These results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1. BACKGROUNDIn human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2-M DNA-damage checkpoint.RESULTSHere, we show that the activity of Cdc25 decreased following exposure to ionizing radiation. The irradiation-induced decrease in Cdc25 activity was suppressed by wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinases, and was dependent on the function of the gene that is mutated in ataxia telangiectasia. We also identified two human kinases that phosphorylate and inactivate Cdc25 in vitro. One is the previously characterized Chk1 kinase. The second is novel and is homologous to the Cds1/Rad53 family of checkpoint kinases in yeast. Human Cds1 was found to be activated in response to DNA damage.CONCLUSIONSThese results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1. In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2-M DNA-damage checkpoint. Here, we show that the activity of Cdc25 decreased following exposure to ionizing radiation. The irradiation-induced decrease in Cdc25 activity was suppressed by wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinases, and was dependent on the function of the gene that is mutated in ataxia telangiectasia. We also identified two human kinases that phosphorylate and inactivate Cdc25 in vitro. One is the previously characterized Chk1 kinase. The second is novel and is homologous to the Cds1/Rad53 family of checkpoint kinases in yeast. Human Cds1 was found to be activated in response to DNA damage. These results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1. Background: In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2–M DNA-damage checkpoint. Results: Here, we show that the activity of Cdc25 decreased following exposure to ionizing radiation. The irradiation-induced decrease in Cdc25 activity was suppressed by wortmannin, an inhibitor of phosphatidylinositol (PI) 3-kinases, and was dependent on the function of the gene that is mutated in ataxia telangiectasia. We also identified two human kinases that phosphorylate and inactivate Cdc25 in vitro. One is the previously characterized Chk1 kinase. The second is novel and is homologous to the Cds1/Rad53 family of checkpoint kinases in yeast. Human Cds1 was found to be activated in response to DNA damage. Conclusions: These results suggest that, in human cells, the DNA-damage checkpoint involves direct inactivation of Cdc25 catalyzed by Cds1 and/or Chk1. |
Author | de Weyer, Inez Van Luyten, Walter H.M.L. Blasina, Alessandra Laus, Marc C. McGowan, Clare H. Parker, Andrew E. |
Author_xml | – sequence: 1 givenname: Alessandra surname: Blasina fullname: Blasina, Alessandra organization: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA – sequence: 2 givenname: Inez Van surname: de Weyer fullname: de Weyer, Inez Van organization: Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium – sequence: 3 givenname: Marc C. surname: Laus fullname: Laus, Marc C. organization: Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium – sequence: 4 givenname: Walter H.M.L. surname: Luyten fullname: Luyten, Walter H.M.L. organization: Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium – sequence: 5 givenname: Andrew E. surname: Parker fullname: Parker, Andrew E. organization: Department of Experimental Molecular Biology, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium, Zeneca Pharmaceutical, Alderley Edge Cheshire, UK – sequence: 6 givenname: Clare H. surname: McGowan fullname: McGowan, Clare H. organization: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9889122$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkE1LxDAQhoMo67r6E4ScRA_VJE3zcRJZ_IIFD7v3kKZTG22b2rTC_nvr7uLV08DMM_MOzxk6bkMLCF1ScksJFXdrogVJtGLsWusbRQinCT9Cc6qkTgjn2TGa_yGn6CzGD0IoU1rM0EwrpSljc7R-wNXY2BZXoQl1eB8BhxIPFWBXgfvsgm8H_OlbGwEvi0hx4XtwQ73Fvq187oc4tR3LcFeF2FV2mMBzdFLaOsLFoS7Q5ulxs3xJVm_Pr8uHVeJ4JodEpYxwyXLtiNQs54IwRQQjzDIrypIUae7k9LEVMhdSKy2FygTkhbRKUkgX6Gp_tuvD1whxMI2PDurathDGaITOsimI_QtSSYVIeTqB2R50fYixh9J0vW9svzWUmF_pZifd_Bo1WpuddMOnvctDwJg3UPxtHSxP8_v9HCYb3x56E52H1sFepimC_yfhBz-KkTs |
CitedBy_id | crossref_primary_10_1016_S0955_0674_00_00154_X crossref_primary_10_1007_s11274_019_2762_2 crossref_primary_10_1038_sj_onc_1203124 crossref_primary_10_1091_mbc_11_1_1 crossref_primary_10_1073_pnas_172382899 crossref_primary_10_1021_cr2001367 crossref_primary_10_1242_jcs_00908 crossref_primary_10_1074_jbc_M412065200 crossref_primary_10_1158_1535_7163_MCT_06_0371 crossref_primary_10_1016_j_ccr_2005_01_009 crossref_primary_10_1038_sj_emboj_7600999 crossref_primary_10_1038_nrd963 crossref_primary_10_1038_sj_cdd_4401461 crossref_primary_10_1242_jcs_113_15_2659 crossref_primary_10_1074_jbc_M009727200 crossref_primary_10_1248_bpb_35_18 crossref_primary_10_1128_MCB_22_6_1868_1880_2002 crossref_primary_10_1016_j_cellsig_2008_05_007 crossref_primary_10_1038_sj_onc_1204574 crossref_primary_10_1006_bbrc_2001_6095 crossref_primary_10_1007_s00018_011_0875_3 crossref_primary_10_1074_jbc_M312215200 crossref_primary_10_1097_00029330_200712010_00010 crossref_primary_10_1080_15384101_2016_1249075 crossref_primary_10_1128_MCB_20_13_4543_4552_2000 crossref_primary_10_1128_JVI_03126_13 crossref_primary_10_52420_2071_5943_2023_22_3_126_136 crossref_primary_10_1667_0033_7587_2000_153_0371_IRIMAP_2_0_CO_2 crossref_primary_10_1089_ars_2005_7_761 crossref_primary_10_1128_MCB_24_22_9968_9985_2004 crossref_primary_10_1038_sj_onc_1203015 crossref_primary_10_1128_MCB_20_12_4288_4294_2000 crossref_primary_10_1091_mbc_12_3_551 crossref_primary_10_1074_jbc_M303604200 crossref_primary_10_1016_S0014_5793_00_02370_X crossref_primary_10_1128_MCB_21_12_4005_4015_2001 crossref_primary_10_1186_bcr435 crossref_primary_10_1002_ijc_10272 crossref_primary_10_1038_35103059 crossref_primary_10_1074_jbc_M111705200 crossref_primary_10_1038_35075107 crossref_primary_10_1074_jbc_M106460200 crossref_primary_10_1128_MCB_22_12_4419_4432_2002 crossref_primary_10_1016_j_bbrc_2018_08_080 crossref_primary_10_1016_j_ceb_2013_07_007 crossref_primary_10_1016_S0167_4781_01_00204_4 crossref_primary_10_1074_jbc_M307088200 crossref_primary_10_1007_BF01279894 crossref_primary_10_1002_rcm_3223 crossref_primary_10_3390_molecules25030501 crossref_primary_10_1128_MCB_20_23_8758_8766_2000 crossref_primary_10_1038_sj_onc_1206760 crossref_primary_10_1016_j_plaphy_2013_10_001 crossref_primary_10_1038_35036406 crossref_primary_10_1083_jcb_146_3_573 crossref_primary_10_1002_mc_20087 crossref_primary_10_1038_nature04384 crossref_primary_10_1091_mbc_10_12_4231 crossref_primary_10_1128_MCB_19_6_4262 crossref_primary_10_1074_jbc_M200822200 crossref_primary_10_1038_nrc2251 crossref_primary_10_1074_jbc_M208321200 crossref_primary_10_1093_mutage_gei063 crossref_primary_10_26508_lsa_202101022 crossref_primary_10_1006_geno_1999_5865 crossref_primary_10_1016_S1097_2765_02_00527_0 crossref_primary_10_1091_mbc_e08_01_0020 crossref_primary_10_1016_S1097_2765_00_80340_8 crossref_primary_10_1200_JCO_2011_37_1476 crossref_primary_10_1105_tpc_106_045047 crossref_primary_10_1242_jcs_01570 crossref_primary_10_1002_bies_10101 crossref_primary_10_1016_S0014_4800_03_00088_1 crossref_primary_10_1128_MCB_22_2_555_566_2002 crossref_primary_10_1021_pr700623p crossref_primary_10_14348_molcells_2014_2259 crossref_primary_10_1091_mbc_11_5_1535 crossref_primary_10_1016_S0014_5793_01_02205_0 crossref_primary_10_1016_j_bbamcr_2010_01_005 crossref_primary_10_1038_sj_onc_1205850 crossref_primary_10_1016_S0168_9525_99_01798_9 crossref_primary_10_1074_jbc_M600403200 crossref_primary_10_1074_jbc_275_14_10342 crossref_primary_10_1038_sj_onc_1205229 crossref_primary_10_1074_jbc_M302484200 crossref_primary_10_1038_sj_neo_7900175 crossref_primary_10_1242_jcs_01086 crossref_primary_10_1073_pnas_190030497 crossref_primary_10_1128_MCB_21_4_1066_1076_2001 crossref_primary_10_1006_taap_2000_8966 crossref_primary_10_1631_jzus_B1600306 crossref_primary_10_1101_gad_842500 crossref_primary_10_1074_jbc_M102946200 crossref_primary_10_1016_S0960_9822_00_00026_9 crossref_primary_10_1667_RR1603_1 crossref_primary_10_1093_genetics_165_4_1717 crossref_primary_10_3390_cells10123327 crossref_primary_10_1038_ja_2014_62 crossref_primary_10_1038_35044005 crossref_primary_10_1016_S0959_437X_00_00160_X crossref_primary_10_1074_jbc_274_44_31463 crossref_primary_10_3390_biom5043204 crossref_primary_10_1016_S0361_090X_03_00063_1 crossref_primary_10_1016_S0960_9822_99_80486_2 crossref_primary_10_1074_jbc_M107978200 crossref_primary_10_1101_gad_14_12_1448 crossref_primary_10_1158_1535_7163_621_3_5 crossref_primary_10_1111_febs_15240 crossref_primary_10_1016_j_dnarep_2004_03_033 crossref_primary_10_1101_gad_1157503 crossref_primary_10_1128_JVI_77_2_1257_1267_2003 crossref_primary_10_1242_jcs_113_10_1727 crossref_primary_10_1091_mbc_e03_02_0061 crossref_primary_10_1038_nrc1296 crossref_primary_10_1038_sj_onc_1204665 crossref_primary_10_1101_sqb_2000_65_489 crossref_primary_10_1074_jbc_M005782200 crossref_primary_10_1074_jbc_M306683200 crossref_primary_10_1016_S0006_291X_02_00739_8 crossref_primary_10_1080_12265071_2002_9647661 crossref_primary_10_1074_jbc_M104414200 crossref_primary_10_1074_jbc_M002942200 crossref_primary_10_1038_onc_2008_369 crossref_primary_10_1074_jbc_M609261200 crossref_primary_10_1074_jbc_M404440200 crossref_primary_10_1667_RR3235 crossref_primary_10_1038_sj_emboj_7600328 crossref_primary_10_1038_sj_onc_1202925 crossref_primary_10_1074_jbc_M007665200 crossref_primary_10_1007_s13258_011_0201_3 crossref_primary_10_1097_00008390_200404000_00007 crossref_primary_10_1080_15257770500269556 crossref_primary_10_1128_MCB_21_10_3398_3404_2001 crossref_primary_10_1248_bpb_30_1379 crossref_primary_10_1146_annurev_biochem_69_1_829 crossref_primary_10_1016_S0955_0674_00_00149_6 crossref_primary_10_1074_jbc_275_20_15363 crossref_primary_10_1126_science_286_5449_2528 crossref_primary_10_1038_cdd_2011_182 crossref_primary_10_2478_s11658_014_0200_x crossref_primary_10_1038_sj_onc_1206613 crossref_primary_10_1101_gad_14_3_278 crossref_primary_10_1074_jbc_M213185200 crossref_primary_10_1038_sj_cdd_4401801 crossref_primary_10_1074_jbc_M403232200 crossref_primary_10_1038_35004614 crossref_primary_10_1242_jcs_113_22_3889 crossref_primary_10_2217_fmb_13_127 crossref_primary_10_1016_j_ceb_2004_09_005 crossref_primary_10_1074_jbc_M410152200 crossref_primary_10_1016_j_cellsig_2014_05_004 crossref_primary_10_1016_j_ejcb_2017_02_006 crossref_primary_10_1083_jcb_151_7_1381 crossref_primary_10_1126_science_288_5470_1425 crossref_primary_10_1016_S0955_0674_99_80036_2 crossref_primary_10_1126_science_287_5459_1824 crossref_primary_10_1093_embo_reports_kvf069 crossref_primary_10_1073_pnas_98_1_125 crossref_primary_10_1158_1078_0432_CCR_10_1215 crossref_primary_10_1002_jat_2845 crossref_primary_10_1016_j_bbrc_2004_03_117 crossref_primary_10_1073_pnas_191557598 crossref_primary_10_1111_j_1440_1827_2004_01585_x crossref_primary_10_1128_MCB_19_11_7410 crossref_primary_10_1016_j_virol_2008_01_038 crossref_primary_10_1016_j_febslet_2007_05_053 crossref_primary_10_1074_jbc_275_8_5600 crossref_primary_10_1101_gad_14_3_289 crossref_primary_10_1016_S0014_5793_01_02756_9 crossref_primary_10_1074_jbc_M100728200 crossref_primary_10_1158_1535_7163_MCT_04_0274 crossref_primary_10_1101_sqb_2000_65_547 crossref_primary_10_1128_JVI_80_5_2257_2266_2006 crossref_primary_10_1016_S0014_5793_02_03327_6 crossref_primary_10_1016_S0960_9822_01_00626_1 crossref_primary_10_1128_MCB_23_22_8161_8171_2003 crossref_primary_10_1091_mbc_10_4_833 crossref_primary_10_1016_j_canlet_2022_01_018 crossref_primary_10_1016_j_toxlet_2013_01_019 crossref_primary_10_1074_jbc_M400015200 crossref_primary_10_1128_MCB_21_5_1499_1508_2001 crossref_primary_10_1146_annurev_pharmtox_40_1_617 crossref_primary_10_1074_mcp_M110_005157 crossref_primary_10_1006_dbio_2000_9968 crossref_primary_10_1074_jbc_M507150200 crossref_primary_10_1073_pnas_96_24_13777 crossref_primary_10_1126_science_286_5442_1162 crossref_primary_10_1074_jbc_M001244200 crossref_primary_10_1091_mbc_e03_03_0168 crossref_primary_10_1042_BJ20041966 crossref_primary_10_1073_pnas_182557299 crossref_primary_10_1128_MCB_21_4_1329_1335_2001 |
Cites_doi | 10.1016/0092-8674(92)90593-2 10.1016/0092-8674(94)90379-4 10.1038/26766 10.1038/363368a0 10.1038/387520a0 10.1074/jbc.271.22.13283 10.1002/j.1460-2075.1994.tb06750.x 10.1002/j.1460-2075.1992.tb05179.x 10.1083/jcb.142.6.1559 10.1101/gad.12.3.382 10.1016/S0960-9822(06)00189-8 10.1126/science.280.5365.909 10.1126/science.277.5331.1450 10.1016/0092-8674(91)90294-9 10.1091/mbc.6.2.199 10.1016/0076-6879(88)59039-0 10.1016/S0021-9258(18)43836-7 10.1126/science.281.5383.1674 10.1126/science.271.5247.357 10.1126/science.277.5331.1501 10.1016/0092-8674(95)90482-4 10.1002/j.1460-2075.1994.tb06417.x 10.1016/0092-8674(93)90500-P 10.1126/science.2683079 10.1016/S0092-8674(00)80487-0 10.1101/gad.10.19.2401 10.1038/387516a0 10.1126/science.277.5331.1495 10.1126/science.274.5293.1664 10.1101/gad.8.20.2401 10.1038/374817a0 10.1083/jcb.138.5.1105 10.1016/S0968-0004(00)89072-6 10.1016/0092-8674(93)90321-G 10.1073/pnas.88.23.10500 10.1101/gad.10.4.395 10.1126/science.1384126 10.1073/pnas.87.13.5139 10.1126/science.278.5345.1957 10.1016/0092-8674(93)90499-G 10.1126/science.277.5331.1497 10.1126/science.8036497 10.1038/40439 10.1242/jcs.109.5.1081 10.1091/mbc.8.6.1013 10.1101/gad.10.19.2383 10.1083/jcb.134.4.963 10.1073/pnas.77.12.7315 10.1002/j.1460-2075.1995.tb07210.x |
ContentType | Journal Article |
Copyright | 1999 Elsevier Science Ltd |
Copyright_xml | – notice: 1999 Elsevier Science Ltd |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 7X8 |
DOI | 10.1016/S0960-9822(99)80041-4 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Nucleic Acids Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Nucleic Acids Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic Nucleic Acids Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1879-0445 |
EndPage | 10 |
ExternalDocumentID | 10_1016_S0960_9822_99_80041_4 9889122 S0960982299800414 |
Genre | Research Support, U.S. Gov't, Non-P.H.S Journal Article |
GroupedDBID | --- --K -DZ -~X 0R~ 1RT 1~5 29F 2WC 4.4 457 4G. 53G 5GY 62- 6I. 6J9 7-5 AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAIKJ AAKRW AALRI AAQXK AAUCE AAVLU AAXJY AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ADBBV ADEZE ADJPV ADMUD AEFWE AENEX AEXQZ AFTJW AGHFR AGHSJ AGKMS AGUBO AHHHB AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CAG COF CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FGOYB FIRID HZ~ IHE IXB J1W JIG LX5 M3Z M41 NCXOZ O-L O9- OK1 OZT P2P R2- RCE ROL RPZ SCP SDG SES SSZ TR2 UHS WQ6 XPP ZA5 ZGI 0SF AAMRU ADVLN AKAPO AKRWK CGR CUY CVF ECM EIF NPM 5VS AAQFI AAYXX CITATION FEDTE G-2 HVGLF RIG SEW XIH Y6R 7TM 7X8 |
ID | FETCH-LOGICAL-c457t-8320472b9c0792b4602806202a2a6ff0d3bc7012a67b6798976856ebd7a871e3 |
IEDL.DBID | IXB |
ISSN | 0960-9822 |
IngestDate | Fri Aug 16 04:09:48 EDT 2024 Fri Aug 16 22:05:44 EDT 2024 Thu Sep 26 17:15:57 EDT 2024 Sat Sep 28 08:36:17 EDT 2024 Fri Feb 23 02:27:25 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c457t-8320472b9c0792b4602806202a2a6ff0d3bc7012a67b6798976856ebd7a871e3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0960982299800414 |
PMID | 9889122 |
PQID | 17166343 |
PQPubID | 23462 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_69554572 proquest_miscellaneous_17166343 crossref_primary_10_1016_S0960_9822_99_80041_4 pubmed_primary_9889122 elsevier_sciencedirect_doi_10_1016_S0960_9822_99_80041_4 |
PublicationCentury | 1900 |
PublicationDate | 1999-01-14 |
PublicationDateYYYYMMDD | 1999-01-14 |
PublicationDate_xml | – month: 01 year: 1999 text: 1999-01-14 day: 14 |
PublicationDecade | 1990 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Current biology |
PublicationTitleAlternate | Curr Biol |
PublicationYear | 1999 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Walworth, Davey, Beach (BIB33) 1993; 363 Jinno, Nagat, Igarashi, Kanaoka, Nojima, Okayama (BIB14) 1994; 13 Allen, Zhou, Siede, Friedberg, Elledge (BIB52) 1994; 8 Hartley, Gell, Smith, Zhang, Divecha, Connelly (BIB22) 1995; 82 Blasina, Paegle, McGowan (BIB6) 1997; 8 Baskaran, Wood, Whitaker, Canman, Morgan, Xu (BIB28) 1997; 387 Poon, Chau, Yamashita, Hunter (BIB9) 1997; 57 El-Deiry, Tokino, Velculescu, Levy, Parsons, Trent (BIB3) 1993; 75 McGowan, Russell (BIB57) 1995; 14 Jin, Gu, Morgan (BIB7) 1996; 134 Lindsay, Griffiths, Edwards, Christensen, Murray, Osman (BIB48) 1998; 12 Yaffe, Rittinger, Volinia, Caron, Aitken, Leffers (BIB39) 1997; 91 Murakami, Okayama (BIB32) 1995; 374 Peng, Graves, Thoma, Wu, Shaw, Piwnica-Worms (BIB19) 1997; 277 Peng, Graves, Ogg, Thoma, Byrnes, Wu (BIB41) 1998; 9 Parker, Piwnica-Worms (BIB54) 1992; 257 Harper, Adami, Wei, Keyomarsi, Elledge (BIB4) 1993; 75 Poon, Jiang, Toyoshima, Hunter (BIB8) 1996; 271 Kastan, Zhan, El-Deiry, Carrier, Jacks, Walsh (BIB27) 1992; 71 Sibon, Stevenson, Theurkauf (BIB50) 1997; 388 Cohen, Alemany, Hemmings, Resink, Stralfors, Tung (BIB55) 1988; 159 Nishijima, Nishitani, Seki, Nishimoto (BIB15) 1997; 138 Al-Khodairy, Carr (BIB49) 1992; 11 Khanna, Lavin (BIB30) 1993; 8 Ford, Al-Khodairy, Fotou, Sheldrick, Griffiths, Carr (BIB44) 1994; 265 Kumagai, Dunphy (BIB53) 1996; 6 Harlow, Lane (BIB56) 1988 Dulic, Kaufmann, Wilson, Tlsty, Lees, Harper (BIB5) 1994; 76 Hoffmann, Draetta, Karsenti (BIB13) 1994; 13 Galaktionov, Beach (BIB12) 1991; 67 Sun, Fay, Marini, Foiani, Stern (BIB46) 1996; 10 Hofmann, Bucher (BIB34) 1995; 20 Fogarty, Campbell, Abu-Shumays, de Staint Phall, Yu, Uy (BIB51) 1997; 7 Gabrielli, De Souza, Tonks, Clark, Hayward, Ellem (BIB17) 1996; 7 Millar, Blevitt, Gerace, Sadhu, Featherstone, Russell (BIB16) 1991; 88 Kumagai, Guo, Emami, Wang, Dunphy (BIB42) 1998; 142 Zeng, Forbes, Wu, Moreno, Piwnica-Worms, Enoch (BIB43) 1998; 395 Ogg, Gabrielli, Piwnica-Worms (BIB18) 1994; 269 Painter, Young (BIB25) 1980; 77 Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge (BIB35) 1997; 277 Shafman, Khanna, Kedar, Spring, Kozlov, Yen (BIB29) 1997; 387 Nagata, Igarashi, Jinno, Suto, Okayama (BIB11) 1991; 3 Sadhu, Reed, Richardson, Russell (BIB10) 1990; 87 Zhou, Elledge (BIB45) 1993; 75 Sanchez, Desany, Jones, Liu, Wang, Elledge (BIB47) 1996; 271 Price, Youmell (BIB23) 1996; 56 Canman, Wolff, Chen, Fornace, Kastan (BIB26) 1994; 54 Boddy, Furnari, Mondesert, Russell (BIB36) 1998; 280 Yaffe, Schutkowski, Shen, Zhou, Stukenberg, Rahfeld (BIB40) 1997; 278 Xu, Baltimore (BIB31) 1996; 10 Weinert (BIB38) 1997; 277 Furnari, Rhind, Russell (BIB37) 1997; 277 Zampetti-Bosseler, Scott (BIB24) 1981; 39 Hawley, Friend (BIB20) 1996; 10 Hartwell, Weinert (BIB1) 1989; 246 Banin, Moyal, Shieh, Taya, Anderson, Chessa (BIB21) 1998; 281 Elledge (BIB2) 1997; 274 Hartley (10.1016/S0960-9822(99)80041-4_BIB22) 1995; 82 Ogg (10.1016/S0960-9822(99)80041-4_BIB18) 1994; 269 Parker (10.1016/S0960-9822(99)80041-4_BIB54) 1992; 257 Weinert (10.1016/S0960-9822(99)80041-4_BIB38) 1997; 277 Zhou (10.1016/S0960-9822(99)80041-4_BIB45) 1993; 75 Hofmann (10.1016/S0960-9822(99)80041-4_BIB34) 1995; 20 Painter (10.1016/S0960-9822(99)80041-4_BIB25) 1980; 77 El-Deiry (10.1016/S0960-9822(99)80041-4_BIB3) 1993; 75 Dulic (10.1016/S0960-9822(99)80041-4_BIB5) 1994; 76 Nishijima (10.1016/S0960-9822(99)80041-4_BIB15) 1997; 138 Harlow (10.1016/S0960-9822(99)80041-4_BIB56) 1988 Blasina (10.1016/S0960-9822(99)80041-4_BIB6) 1997; 8 Sun (10.1016/S0960-9822(99)80041-4_BIB46) 1996; 10 Sibon (10.1016/S0960-9822(99)80041-4_BIB50) 1997; 388 Allen (10.1016/S0960-9822(99)80041-4_BIB52) 1994; 8 Zampetti-Bosseler (10.1016/S0960-9822(99)80041-4_BIB24) 1981; 39 Xu (10.1016/S0960-9822(99)80041-4_BIB31) 1996; 10 Ford (10.1016/S0960-9822(99)80041-4_BIB44) 1994; 265 Lindsay (10.1016/S0960-9822(99)80041-4_BIB48) 1998; 12 Elledge (10.1016/S0960-9822(99)80041-4_BIB2) 1997; 274 Peng (10.1016/S0960-9822(99)80041-4_BIB19) 1997; 277 Yaffe (10.1016/S0960-9822(99)80041-4_BIB39) 1997; 91 Murakami (10.1016/S0960-9822(99)80041-4_BIB32) 1995; 374 Poon (10.1016/S0960-9822(99)80041-4_BIB9) 1997; 57 Cohen (10.1016/S0960-9822(99)80041-4_BIB55) 1988; 159 Kumagai (10.1016/S0960-9822(99)80041-4_BIB53) 1996; 6 Kumagai (10.1016/S0960-9822(99)80041-4_BIB42) 1998; 142 Shafman (10.1016/S0960-9822(99)80041-4_BIB29) 1997; 387 Jin (10.1016/S0960-9822(99)80041-4_BIB7) 1996; 134 Galaktionov (10.1016/S0960-9822(99)80041-4_BIB12) 1991; 67 Hawley (10.1016/S0960-9822(99)80041-4_BIB20) 1996; 10 Fogarty (10.1016/S0960-9822(99)80041-4_BIB51) 1997; 7 Sanchez (10.1016/S0960-9822(99)80041-4_BIB35) 1997; 277 Yaffe (10.1016/S0960-9822(99)80041-4_BIB40) 1997; 278 McGowan (10.1016/S0960-9822(99)80041-4_BIB57) 1995; 14 Furnari (10.1016/S0960-9822(99)80041-4_BIB37) 1997; 277 Boddy (10.1016/S0960-9822(99)80041-4_BIB36) 1998; 280 Poon (10.1016/S0960-9822(99)80041-4_BIB8) 1996; 271 Sanchez (10.1016/S0960-9822(99)80041-4_BIB47) 1996; 271 Hartwell (10.1016/S0960-9822(99)80041-4_BIB1) 1989; 246 Baskaran (10.1016/S0960-9822(99)80041-4_BIB28) 1997; 387 Jinno (10.1016/S0960-9822(99)80041-4_BIB14) 1994; 13 Sadhu (10.1016/S0960-9822(99)80041-4_BIB10) 1990; 87 Banin (10.1016/S0960-9822(99)80041-4_BIB21) 1998; 281 Walworth (10.1016/S0960-9822(99)80041-4_BIB33) 1993; 363 Harper (10.1016/S0960-9822(99)80041-4_BIB4) 1993; 75 Peng (10.1016/S0960-9822(99)80041-4_BIB41) 1998; 9 Nagata (10.1016/S0960-9822(99)80041-4_BIB11) 1991; 3 Kastan (10.1016/S0960-9822(99)80041-4_BIB27) 1992; 71 Hoffmann (10.1016/S0960-9822(99)80041-4_BIB13) 1994; 13 Canman (10.1016/S0960-9822(99)80041-4_BIB26) 1994; 54 Millar (10.1016/S0960-9822(99)80041-4_BIB16) 1991; 88 Al-Khodairy (10.1016/S0960-9822(99)80041-4_BIB49) 1992; 11 Gabrielli (10.1016/S0960-9822(99)80041-4_BIB17) 1996; 7 Price (10.1016/S0960-9822(99)80041-4_BIB23) 1996; 56 Khanna (10.1016/S0960-9822(99)80041-4_BIB30) 1993; 8 Zeng (10.1016/S0960-9822(99)80041-4_BIB43) 1998; 395 |
References_xml | – volume: 14 start-page: 2166 year: 1995 end-page: 2175 ident: BIB57 article-title: Cell cycle regulation of human WEE1 publication-title: EMBO J contributor: fullname: Russell – volume: 277 start-page: 1501 year: 1997 end-page: 1505 ident: BIB19 article-title: Mitotic and G2 checkpoint control: regulation of 14–3-3 protein binding by phosphorylation of Cdc25C on serine-216 publication-title: Science contributor: fullname: Piwnica-Worms – volume: 75 start-page: 817 year: 1993 end-page: 825 ident: BIB3 article-title: WAF1, a potential mediator of p53 tumor suppression publication-title: Cell contributor: fullname: Trent – volume: 91 start-page: 961 year: 1997 end-page: 971 ident: BIB39 article-title: The structural basis for 14–3-3: phosphopeptide binding specificity publication-title: Cell contributor: fullname: Leffers – volume: 271 start-page: 357 year: 1996 end-page: 360 ident: BIB47 article-title: Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways publication-title: Science contributor: fullname: Elledge – volume: 395 start-page: 507 year: 1998 end-page: 510 ident: BIB43 article-title: Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1 publication-title: Nature contributor: fullname: Enoch – volume: 77 start-page: 7315 year: 1980 end-page: 7317 ident: BIB25 article-title: Radiosensitivity in ataxia-telangiectasia: a new explanation publication-title: Proc Natl Acad USA contributor: fullname: Young – volume: 138 start-page: 1105 year: 1997 end-page: 1116 ident: BIB15 article-title: A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34cdc2/Cyclin B activation in hamster BHK21 cells arrested with hydroxyurea publication-title: J Cell Biol contributor: fullname: Nishimoto – volume: 71 start-page: 587 year: 1992 end-page: 589 ident: BIB27 article-title: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia publication-title: Cell contributor: fullname: Walsh – volume: 10 start-page: 2383 year: 1996 end-page: 2388 ident: BIB20 article-title: Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53 publication-title: Genes Dev contributor: fullname: Friend – volume: 271 start-page: 13283 year: 1996 end-page: 13291 ident: BIB8 article-title: Cyclin-dependent kinases are inactivated by a combination of p21 and Thr14/Tyr15 phosphorylation after UV-induced DNA damage publication-title: J Biol Chem contributor: fullname: Hunter – volume: 388 start-page: 93 year: 1997 end-page: 97 ident: BIB50 article-title: DNA-replication, checkpoint at the publication-title: Nature contributor: fullname: Theurkauf – volume: 88 start-page: 10500 year: 1991 end-page: 10504 ident: BIB16 article-title: p55 publication-title: Proc Natl Acad Sci USA contributor: fullname: Russell – volume: 39 start-page: 547 year: 1981 end-page: 558 ident: BIB24 article-title: Cell death, chromosome damage and mitotic delay in normal, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation publication-title: Int J Radiat Biol contributor: fullname: Scott – volume: 269 start-page: 30461 year: 1994 end-page: 30469 ident: BIB18 article-title: Purification of a serine-kinase that associates with and phosphorylates human Cdc25C on serine 216 publication-title: J Biol Chem contributor: fullname: Piwnica-Worms – volume: 387 start-page: 516 year: 1997 end-page: 519 ident: BIB28 article-title: Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation publication-title: Nature contributor: fullname: Xu – volume: 7 start-page: 1081 year: 1996 end-page: 1093 ident: BIB17 article-title: Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells publication-title: J Cell Sci contributor: fullname: Ellem – volume: 87 start-page: 5139 year: 1990 end-page: 5143 ident: BIB10 article-title: Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 publication-title: Proc Natl Acad Sci USA contributor: fullname: Russell – volume: 54 start-page: 5054 year: 1994 end-page: 5058 ident: BIB26 article-title: The p53-dependent G1 cell cycle checkpoint pathway and Ataxia-Telangiectasia publication-title: Cancer Res contributor: fullname: Kastan – volume: 265 start-page: 533 year: 1994 end-page: 535 ident: BIB44 article-title: 14–3-3 protein homologs required for the DNA damage checkpoint in fission yeast publication-title: Science contributor: fullname: Carr – volume: 8 start-page: 1 year: 1997 end-page: 11 ident: BIB6 article-title: The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation induced damage in HeLa Cells publication-title: Mol Biol Cell contributor: fullname: McGowan – volume: 142 start-page: 1559 year: 1998 end-page: 1569 ident: BIB42 article-title: The publication-title: J Cell Biol contributor: fullname: Dunphy – volume: 277 start-page: 1497 year: 1997 end-page: 1501 ident: BIB35 article-title: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through cdc25 publication-title: Science contributor: fullname: Elledge – volume: 277 start-page: 1450 year: 1997 ident: BIB38 article-title: A DNA damage checkpoint meets the cell cycle engine publication-title: Science contributor: fullname: Weinert – volume: 374 start-page: 817 year: 1995 end-page: 819 ident: BIB32 article-title: A kinase from fission yeast responsible for blocking mitosis in S phase publication-title: Nature contributor: fullname: Okayama – volume: 20 start-page: 347 year: 1995 end-page: 349 ident: BIB34 article-title: The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors publication-title: Trends Biochem Sci contributor: fullname: Bucher – volume: 281 start-page: 1674 year: 1998 end-page: 1677 ident: BIB21 article-title: Enhanced phosphorylation of p53 by ATM in response to DNA damage publication-title: Science contributor: fullname: Chessa – volume: 82 start-page: 849 year: 1995 end-page: 856 ident: BIB22 article-title: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product publication-title: Cell contributor: fullname: Connelly – volume: 56 start-page: 246 year: 1996 end-page: 250 ident: BIB23 article-title: The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage publication-title: Cancer Res contributor: fullname: Youmell – volume: 67 start-page: 1181 year: 1991 end-page: 1194 ident: BIB12 article-title: Specific activation of cdc25 tyrosine phosphatases by β-type cyclins: evidence for multiple roles of mitotic cyclins publication-title: Cell contributor: fullname: Beach – volume: 274 start-page: 1664 year: 1997 end-page: 1671 ident: BIB2 article-title: Cell cycle checkpoints; preventing an identity crisis publication-title: Science contributor: fullname: Elledge – volume: 363 start-page: 368 year: 1993 end-page: 371 ident: BIB33 article-title: Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2 publication-title: Nature contributor: fullname: Beach – volume: 246 start-page: 629 year: 1989 end-page: 634 ident: BIB1 article-title: Checkpoints: controls that ensure the order of cell cycle events publication-title: Science contributor: fullname: Weinert – volume: 10 start-page: 395 year: 1996 end-page: 406 ident: BIB46 article-title: Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways publication-title: Genes Dev contributor: fullname: Stern – year: 1988 ident: BIB56 publication-title: Antibodies contributor: fullname: Lane – volume: 3 start-page: 959 year: 1991 end-page: 968 ident: BIB11 article-title: An additional homolog of the fission yeast publication-title: New Biol contributor: fullname: Okayama – volume: 277 start-page: 1495 year: 1997 end-page: 1497 ident: BIB37 article-title: Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase publication-title: Science contributor: fullname: Russell – volume: 6 start-page: 199 year: 1996 end-page: 213 ident: BIB53 article-title: Control of the CDC2/Cyclin B complex in publication-title: Mol Biol Cell contributor: fullname: Dunphy – volume: 57 start-page: 5168 year: 1997 end-page: 5178 ident: BIB9 article-title: The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells publication-title: Cancer Res contributor: fullname: Hunter – volume: 75 start-page: 805 year: 1993 end-page: 816 ident: BIB4 article-title: The p21 CDK-interacting protein Cip1 is a potent inhibitor of G1 cyclin dependent kinase publication-title: Cell contributor: fullname: Elledge – volume: 278 start-page: 1957 year: 1997 end-page: 1960 ident: BIB40 article-title: Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism publication-title: Science contributor: fullname: Rahfeld – volume: 280 start-page: 909 year: 1998 end-page: 912 ident: BIB36 article-title: Replication checkpoint enforced by kinases Cds1 and Chk1 publication-title: Science contributor: fullname: Russell – volume: 134 start-page: 963 year: 1996 end-page: 970 ident: BIB7 article-title: Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells publication-title: J Cell Biol contributor: fullname: Morgan – volume: 387 start-page: 520 year: 1997 end-page: 523 ident: BIB29 article-title: Interaction between ATM protein and cABL in response to DNA damage publication-title: Nature contributor: fullname: Yen – volume: 8 start-page: 3307 year: 1993 end-page: 3312 ident: BIB30 article-title: Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells publication-title: Oncogene contributor: fullname: Lavin – volume: 11 start-page: 1343 year: 1992 end-page: 1350 ident: BIB49 article-title: DNA repair mutants defining G2 checkpoint pathways in publication-title: EMBO J contributor: fullname: Carr – volume: 13 start-page: 1549 year: 1994 end-page: 1556 ident: BIB14 article-title: Cdc25A is a novel phosphatase functioning early in the cell cycle publication-title: EMBO J contributor: fullname: Okayama – volume: 159 start-page: 390 year: 1988 end-page: 408 ident: BIB55 article-title: Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle publication-title: Methods Enzymol contributor: fullname: Tung – volume: 8 start-page: 2401 year: 1994 end-page: 2415 ident: BIB52 article-title: The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast publication-title: Genes Dev contributor: fullname: Elledge – volume: 12 start-page: 382 year: 1998 end-page: 395 ident: BIB48 article-title: S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in publication-title: Genes Dev contributor: fullname: Osman – volume: 9 start-page: 197 year: 1998 end-page: 208 ident: BIB41 article-title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14–3-3 protein binding publication-title: Cell Growth Differ contributor: fullname: Wu – volume: 75 start-page: 1119 year: 1993 end-page: 1127 ident: BIB45 article-title: DUN1 encodes a protein kinase that controls the DNA damage response in yeast publication-title: Cell contributor: fullname: Elledge – volume: 10 start-page: 2401 year: 1996 end-page: 2410 ident: BIB31 article-title: Dual roles of ATM in the cellular response to radiation and in cell growth control publication-title: Genes Dev contributor: fullname: Baltimore – volume: 13 start-page: 4302 year: 1994 end-page: 4310 ident: BIB13 article-title: Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition publication-title: EMBO J contributor: fullname: Karsenti – volume: 76 start-page: 1013 year: 1994 end-page: 1023 ident: BIB5 article-title: p53-dependent inhibition of cyclin E/Cdk2 kinase activity in human fibroblasts during radiation-induced G1 arrest publication-title: Cell contributor: fullname: Harper – volume: 7 start-page: 418 year: 1997 end-page: 426 ident: BIB51 article-title: The publication-title: Curr Biol contributor: fullname: Uy – volume: 257 start-page: 1955 year: 1992 end-page: 1957 ident: BIB54 article-title: Inactivation of the p34 publication-title: Science contributor: fullname: Piwnica-Worms – volume: 71 start-page: 587 year: 1992 ident: 10.1016/S0960-9822(99)80041-4_BIB27 article-title: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia publication-title: Cell doi: 10.1016/0092-8674(92)90593-2 contributor: fullname: Kastan – volume: 76 start-page: 1013 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB5 article-title: p53-dependent inhibition of cyclin E/Cdk2 kinase activity in human fibroblasts during radiation-induced G1 arrest publication-title: Cell doi: 10.1016/0092-8674(94)90379-4 contributor: fullname: Dulic – volume: 395 start-page: 507 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB43 article-title: Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1 publication-title: Nature doi: 10.1038/26766 contributor: fullname: Zeng – volume: 56 start-page: 246 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB23 article-title: The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage publication-title: Cancer Res contributor: fullname: Price – volume: 363 start-page: 368 year: 1993 ident: 10.1016/S0960-9822(99)80041-4_BIB33 article-title: Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2 publication-title: Nature doi: 10.1038/363368a0 contributor: fullname: Walworth – volume: 387 start-page: 520 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB29 article-title: Interaction between ATM protein and cABL in response to DNA damage publication-title: Nature doi: 10.1038/387520a0 contributor: fullname: Shafman – volume: 271 start-page: 13283 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB8 article-title: Cyclin-dependent kinases are inactivated by a combination of p21 and Thr14/Tyr15 phosphorylation after UV-induced DNA damage publication-title: J Biol Chem doi: 10.1074/jbc.271.22.13283 contributor: fullname: Poon – volume: 13 start-page: 4302 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB13 article-title: Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition publication-title: EMBO J doi: 10.1002/j.1460-2075.1994.tb06750.x contributor: fullname: Hoffmann – volume: 57 start-page: 5168 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB9 article-title: The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells publication-title: Cancer Res contributor: fullname: Poon – volume: 39 start-page: 547 year: 1981 ident: 10.1016/S0960-9822(99)80041-4_BIB24 article-title: Cell death, chromosome damage and mitotic delay in normal, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation publication-title: Int J Radiat Biol contributor: fullname: Zampetti-Bosseler – volume: 11 start-page: 1343 year: 1992 ident: 10.1016/S0960-9822(99)80041-4_BIB49 article-title: DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe publication-title: EMBO J doi: 10.1002/j.1460-2075.1992.tb05179.x contributor: fullname: Al-Khodairy – volume: 142 start-page: 1559 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB42 article-title: The Xenopus chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts publication-title: J Cell Biol doi: 10.1083/jcb.142.6.1559 contributor: fullname: Kumagai – volume: 12 start-page: 382 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB48 article-title: S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe publication-title: Genes Dev doi: 10.1101/gad.12.3.382 contributor: fullname: Lindsay – year: 1988 ident: 10.1016/S0960-9822(99)80041-4_BIB56 contributor: fullname: Harlow – volume: 7 start-page: 418 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB51 article-title: The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity publication-title: Curr Biol doi: 10.1016/S0960-9822(06)00189-8 contributor: fullname: Fogarty – volume: 280 start-page: 909 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB36 article-title: Replication checkpoint enforced by kinases Cds1 and Chk1 publication-title: Science doi: 10.1126/science.280.5365.909 contributor: fullname: Boddy – volume: 277 start-page: 1450 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB38 article-title: A DNA damage checkpoint meets the cell cycle engine publication-title: Science doi: 10.1126/science.277.5331.1450 contributor: fullname: Weinert – volume: 67 start-page: 1181 year: 1991 ident: 10.1016/S0960-9822(99)80041-4_BIB12 article-title: Specific activation of cdc25 tyrosine phosphatases by β-type cyclins: evidence for multiple roles of mitotic cyclins publication-title: Cell doi: 10.1016/0092-8674(91)90294-9 contributor: fullname: Galaktionov – volume: 6 start-page: 199 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB53 article-title: Control of the CDC2/Cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors publication-title: Mol Biol Cell doi: 10.1091/mbc.6.2.199 contributor: fullname: Kumagai – volume: 54 start-page: 5054 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB26 article-title: The p53-dependent G1 cell cycle checkpoint pathway and Ataxia-Telangiectasia publication-title: Cancer Res contributor: fullname: Canman – volume: 159 start-page: 390 year: 1988 ident: 10.1016/S0960-9822(99)80041-4_BIB55 article-title: Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle publication-title: Methods Enzymol doi: 10.1016/0076-6879(88)59039-0 contributor: fullname: Cohen – volume: 269 start-page: 30461 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB18 article-title: Purification of a serine-kinase that associates with and phosphorylates human Cdc25C on serine 216 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)43836-7 contributor: fullname: Ogg – volume: 281 start-page: 1674 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB21 article-title: Enhanced phosphorylation of p53 by ATM in response to DNA damage publication-title: Science doi: 10.1126/science.281.5383.1674 contributor: fullname: Banin – volume: 271 start-page: 357 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB47 article-title: Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways publication-title: Science doi: 10.1126/science.271.5247.357 contributor: fullname: Sanchez – volume: 277 start-page: 1501 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB19 article-title: Mitotic and G2 checkpoint control: regulation of 14–3-3 protein binding by phosphorylation of Cdc25C on serine-216 publication-title: Science doi: 10.1126/science.277.5331.1501 contributor: fullname: Peng – volume: 82 start-page: 849 year: 1995 ident: 10.1016/S0960-9822(99)80041-4_BIB22 article-title: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product publication-title: Cell doi: 10.1016/0092-8674(95)90482-4 contributor: fullname: Hartley – volume: 3 start-page: 959 year: 1991 ident: 10.1016/S0960-9822(99)80041-4_BIB11 article-title: An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells publication-title: New Biol contributor: fullname: Nagata – volume: 13 start-page: 1549 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB14 article-title: Cdc25A is a novel phosphatase functioning early in the cell cycle publication-title: EMBO J doi: 10.1002/j.1460-2075.1994.tb06417.x contributor: fullname: Jinno – volume: 75 start-page: 817 year: 1993 ident: 10.1016/S0960-9822(99)80041-4_BIB3 article-title: WAF1, a potential mediator of p53 tumor suppression publication-title: Cell doi: 10.1016/0092-8674(93)90500-P contributor: fullname: El-Deiry – volume: 246 start-page: 629 year: 1989 ident: 10.1016/S0960-9822(99)80041-4_BIB1 article-title: Checkpoints: controls that ensure the order of cell cycle events publication-title: Science doi: 10.1126/science.2683079 contributor: fullname: Hartwell – volume: 91 start-page: 961 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB39 article-title: The structural basis for 14–3-3: phosphopeptide binding specificity publication-title: Cell doi: 10.1016/S0092-8674(00)80487-0 contributor: fullname: Yaffe – volume: 10 start-page: 2401 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB31 article-title: Dual roles of ATM in the cellular response to radiation and in cell growth control publication-title: Genes Dev doi: 10.1101/gad.10.19.2401 contributor: fullname: Xu – volume: 387 start-page: 516 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB28 article-title: Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation publication-title: Nature doi: 10.1038/387516a0 contributor: fullname: Baskaran – volume: 277 start-page: 1495 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB37 article-title: Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase publication-title: Science doi: 10.1126/science.277.5331.1495 contributor: fullname: Furnari – volume: 274 start-page: 1664 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB2 article-title: Cell cycle checkpoints; preventing an identity crisis publication-title: Science doi: 10.1126/science.274.5293.1664 contributor: fullname: Elledge – volume: 8 start-page: 2401 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB52 article-title: The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast publication-title: Genes Dev doi: 10.1101/gad.8.20.2401 contributor: fullname: Allen – volume: 374 start-page: 817 year: 1995 ident: 10.1016/S0960-9822(99)80041-4_BIB32 article-title: A kinase from fission yeast responsible for blocking mitosis in S phase publication-title: Nature doi: 10.1038/374817a0 contributor: fullname: Murakami – volume: 138 start-page: 1105 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB15 article-title: A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34cdc2/Cyclin B activation in hamster BHK21 cells arrested with hydroxyurea publication-title: J Cell Biol doi: 10.1083/jcb.138.5.1105 contributor: fullname: Nishijima – volume: 20 start-page: 347 year: 1995 ident: 10.1016/S0960-9822(99)80041-4_BIB34 article-title: The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors publication-title: Trends Biochem Sci doi: 10.1016/S0968-0004(00)89072-6 contributor: fullname: Hofmann – volume: 75 start-page: 1119 year: 1993 ident: 10.1016/S0960-9822(99)80041-4_BIB45 article-title: DUN1 encodes a protein kinase that controls the DNA damage response in yeast publication-title: Cell doi: 10.1016/0092-8674(93)90321-G contributor: fullname: Zhou – volume: 88 start-page: 10500 year: 1991 ident: 10.1016/S0960-9822(99)80041-4_BIB16 article-title: p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.88.23.10500 contributor: fullname: Millar – volume: 10 start-page: 395 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB46 article-title: Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways publication-title: Genes Dev doi: 10.1101/gad.10.4.395 contributor: fullname: Sun – volume: 257 start-page: 1955 year: 1992 ident: 10.1016/S0960-9822(99)80041-4_BIB54 article-title: Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase publication-title: Science doi: 10.1126/science.1384126 contributor: fullname: Parker – volume: 87 start-page: 5139 year: 1990 ident: 10.1016/S0960-9822(99)80041-4_BIB10 article-title: Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.87.13.5139 contributor: fullname: Sadhu – volume: 278 start-page: 1957 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB40 article-title: Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism publication-title: Science doi: 10.1126/science.278.5345.1957 contributor: fullname: Yaffe – volume: 75 start-page: 805 year: 1993 ident: 10.1016/S0960-9822(99)80041-4_BIB4 article-title: The p21 CDK-interacting protein Cip1 is a potent inhibitor of G1 cyclin dependent kinase publication-title: Cell doi: 10.1016/0092-8674(93)90499-G contributor: fullname: Harper – volume: 277 start-page: 1497 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB35 article-title: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through cdc25 publication-title: Science doi: 10.1126/science.277.5331.1497 contributor: fullname: Sanchez – volume: 265 start-page: 533 year: 1994 ident: 10.1016/S0960-9822(99)80041-4_BIB44 article-title: 14–3-3 protein homologs required for the DNA damage checkpoint in fission yeast publication-title: Science doi: 10.1126/science.8036497 contributor: fullname: Ford – volume: 388 start-page: 93 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB50 article-title: DNA-replication, checkpoint at the Drosophila midblastula transition publication-title: Nature doi: 10.1038/40439 contributor: fullname: Sibon – volume: 7 start-page: 1081 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB17 article-title: Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells publication-title: J Cell Sci doi: 10.1242/jcs.109.5.1081 contributor: fullname: Gabrielli – volume: 9 start-page: 197 year: 1998 ident: 10.1016/S0960-9822(99)80041-4_BIB41 article-title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14–3-3 protein binding publication-title: Cell Growth Differ contributor: fullname: Peng – volume: 8 start-page: 1 year: 1997 ident: 10.1016/S0960-9822(99)80041-4_BIB6 article-title: The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation induced damage in HeLa Cells publication-title: Mol Biol Cell doi: 10.1091/mbc.8.6.1013 contributor: fullname: Blasina – volume: 10 start-page: 2383 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB20 article-title: Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53 publication-title: Genes Dev doi: 10.1101/gad.10.19.2383 contributor: fullname: Hawley – volume: 134 start-page: 963 year: 1996 ident: 10.1016/S0960-9822(99)80041-4_BIB7 article-title: Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells publication-title: J Cell Biol doi: 10.1083/jcb.134.4.963 contributor: fullname: Jin – volume: 8 start-page: 3307 year: 1993 ident: 10.1016/S0960-9822(99)80041-4_BIB30 article-title: Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells publication-title: Oncogene contributor: fullname: Khanna – volume: 77 start-page: 7315 year: 1980 ident: 10.1016/S0960-9822(99)80041-4_BIB25 article-title: Radiosensitivity in ataxia-telangiectasia: a new explanation publication-title: Proc Natl Acad USA doi: 10.1073/pnas.77.12.7315 contributor: fullname: Painter – volume: 14 start-page: 2166 year: 1995 ident: 10.1016/S0960-9822(99)80041-4_BIB57 article-title: Cell cycle regulation of human WEE1 publication-title: EMBO J doi: 10.1002/j.1460-2075.1995.tb07210.x contributor: fullname: McGowan |
SSID | ssj0012896 |
Score | 2.1395633 |
Snippet | Background: In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites... In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates... BACKGROUNDIn human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1 |
SubjectTerms | Amino Acid Sequence Androstadienes - pharmacology Autoradiography Blotting, Northern Blotting, Western cdc25 Phosphatases Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - drug effects Cell Cycle Proteins - metabolism Cell Cycle Proteins - radiation effects Cell Line Checkpoint Kinase 1 Checkpoint Kinase 2 DNA Damage DNA Replication - genetics Electrophoresis, Polyacrylamide Gel Enzyme Activation HeLa Cells Humans Molecular Sequence Data Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - drug effects Phosphoprotein Phosphatases - metabolism Phosphoprotein Phosphatases - radiation effects Phosphorylation Protein Kinases - metabolism Protein Kinases - pharmacology Protein-Serine-Threonine Kinases Sequence Alignment Wortmannin |
Title | A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase |
URI | https://dx.doi.org/10.1016/S0960-9822(99)80041-4 https://www.ncbi.nlm.nih.gov/pubmed/9889122 https://search.proquest.com/docview/17166343 https://search.proquest.com/docview/69554572 |
Volume | 9 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELYQCIkF8RTl6YEBBtMk9SMe2wqEALG0oG6WnThqBCQRTYf-e85OCmKokFits2V_F9-dc_Z3CF2yLEhjpjMSxlYTKlNJYkkzQq0WnNuA2sRfkH3m9y_0YcIma2i4fAvjrlW2tr-x6d5aty3dFs1ulefdkSdLc3zlMnasUY4T1HF7ukd8k8F3JgEOFD5fCcLESf-84mlG8I1XUl77QQhd5Z9WxZ_eD93toO02gMT9Zo67aM0We2izKSm52EejPvZl9_C0_Cj9fxlcZhiiPAzaSd6qMi9q_JYX4LzwMJ2FuFn_-wLnxTQ3eT2D5iRiuJqWs2qqaxA8QOO72_HwnrSFE0hCmagJ7FJHAmlkEggZGcp9_jQKIh1pnoF2eiYRAI3mwrgsDIQkMePWpELD-cn2DtF6URb2CGFOoTeMIqRJqLZGxrENEhYKY7llWdpBN0u0VNXQY6ife2MAr3LwKimVh1fRDoqXmKpfelZgwv_qerHUgYI94BIburDlfKYc5Q_v0d5qCS4hbGIi6qDDRnnfs4UVyTCKjv8_rxO01XA5hCSkp2i9_pzbM4hUanOONvqD18enc_9JfgGu9-GU |
link.rule.ids | 315,786,790,3525,27600,27955,27956,45696,45907 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07b9swED64DoJ2Kdo8EPcVDhnSgbUk8yGOrtHAbZwscYtsBClRsOBUEmplyL_vkZITdDACdCVIgvqOPH7UHT8CnPEiylNuChqnzlCmckVTxQrKnJFCuIi5LCTIXov5T_bjlt8OYLa9C-PTKnvf3_n04K37knGP5rgpy_FNEEvzeuUq9apR7AXsIRtQOM33pl9_XS4egwl4pgghS6xPfYOnizxdJ6HwXKnPoR_Kdm1Ruyho2Iou3sDrnkOSaTfMtzBw1QHsd69KPhzCzZSEl_fIqv5dh18zpC4IEj2CBsrWTV1WLVmXFe5fZJZvYtJBcPdAympV2rLdYHGWcNKs6k2zMi1WPILlxbflbE77txNoxrhsKS5UrwNpVRZJlVgmQgg1iRKTGFGggSY2kwiNEdL6QAyykpQLZ3Np8AjlJscwrOrKnQARDFtjL1LZjBlnVZq6KOOxtE44XuQj-LJFSzedQoZ-Sh1DeLWHVyulA7yajSDdYqr_MbVGL_5c09OtDTQuAx_bMJWr7zfaq_6ICZvsriEUMicukxEcd8Z7HC1-kYqT5N3_j-sUXs6XVwu9-H59-R5eddIOMY3ZBxi2f-7dRyQurf3UT8y_mo7kSQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+human+homologue+of+the+checkpoint+kinase+Cds1+directly+inhibits+Cdc25+phosphatase&rft.jtitle=Current+biology&rft.au=Blasina%2C+A&rft.au=de+Weyer%2C+I+V&rft.au=Laus%2C+M+C&rft.au=Luyten%2C+W+H&rft.date=1999-01-14&rft.issn=0960-9822&rft.volume=9&rft.issue=1&rft.spage=1&rft.epage=10&rft_id=info:doi/10.1016%2Fs0960-9822%2899%2980041-4&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-9822&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-9822&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-9822&client=summon |