Micelles of pulmonary surfactant in human amniotic fluid at term
Studies using in vitro analysis have shown that the interaction between pulmonary surfactant and vernix caseosa could explain the appearance of amniotic fluid turbidity. That phenomenon is interpreted based on the "roll-up" hypothesis. We tested the roll-up hypothesis by examining the pres...
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Published in | Pediatric research Vol. 60; no. 2; pp. 196 - 199 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Lippincott Williams & Wilkins
01.08.2006
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Abstract | Studies using in vitro analysis have shown that the interaction between pulmonary surfactant and vernix caseosa could explain the appearance of amniotic fluid turbidity. That phenomenon is interpreted based on the "roll-up" hypothesis. We tested the roll-up hypothesis by examining the presence of micelles of pulmonary surfactant in human amniotic fluid at term. Amniotic fluid samples were collected from each of six healthy pregnant women at term and at 16 wk of gestation. These samples were stained negatively and analyzed using an electron microscope. Ultrastructures present in amniotic fluid were compared with the structure of micelles derived from suspended surfactant TA isolated from bovine lung. Surfactant TA formed spheroidal and rod-shaped micelles 10-70 nm in diameter above the critical micelle concentration. Identical micelle particles were described in human amniotic fluid at term. In addition, surfactant protein B was identified in the micelle fraction of amniotic fluid. However, no micelles were found in human amniotic fluid taken at 16 wk of gestation. Our results support the view that pulmonary surfactant could induce the detachment of vernix caseosa and increase the turbidity of the amniotic fluid. |
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AbstractList | Studies using in vitro analysis have shown that the interaction between pulmonary surfactant and vernix caseosa could explain the appearance of amniotic fluid turbidity. That phenomenon is interpreted based on the "roll-up" hypothesis. We tested the roll-up hypothesis by examining the presence of micelles of pulmonary surfactant in human amniotic fluid at term. Amniotic fluid samples were collected from each of six healthy pregnant women at term and at 16 wk of gestation. These samples were stained negatively and analyzed using an electron microscope. Ultrastructures present in amniotic fluid were compared with the structure of micelles derived from suspended surfactant TA isolated from bovine lung. Surfactant TA formed spheroidal and rod-shaped micelles 10-70 nm in diameter above the critical micelle concentration. Identical micelle particles were described in human amniotic fluid at term. In addition, surfactant protein B was identified in the micelle fraction of amniotic fluid. However, no micelles were found in human amniotic fluid taken at 16 wk of gestation. Our results support the view that pulmonary surfactant could induce the detachment of vernix caseosa and increase the turbidity of the amniotic fluid. |
Author | NISHIJIMA, Koji KOTSUJI, Fumikazu MIURA, Junichiro ORISAKA, Makoto SHUKUNAMI, Ken-Ichi TSUKAHARA, Hirokazu |
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References | Narendran V (pr2006220-bib5) 2000; 48 Castro M (pr2006220-bib11) 2001; 78 Maggio B (pr2006220-bib13) 1988; 945 Dubertret B (pr2006220-bib14) 2002; 298 pr2006220-bib8 pr2006220-bib7 pr2006220-bib1 Agorastos T (pr2006220-bib4) 1986; 22 pr2006220-bib2 Glumoff V (pr2006220-bib15) 2000; 22 Kabin JA (pr2006220-bib6) 1998; 206 Ananthapadmanabhan KP (pr2006220-bib12) 1985; 1 Ross MG (pr2006220-bib17) 1998; 274 Hook GE (pr2006220-bib3) 1978; 117 Fujiwara T (pr2006220-bib9) 1980; 1 Tanaka Y (pr2006220-bib10) 1982; 13 Wright JR (pr2006220-bib16) 1990; 259 |
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SubjectTerms | Amniotic Fluid - chemistry Amniotic Fluid - metabolism Animals Biological and medical sciences Cattle Female General aspects Humans Medical sciences Micelles Microscopy, Electron Pregnancy Pregnancy Trimester, Third - metabolism Pulmonary Surfactant-Associated Protein B - analysis Pulmonary Surfactants - chemistry Pulmonary Surfactants - metabolism Vernix Caseosa - chemistry Vernix Caseosa - metabolism |
Title | Micelles of pulmonary surfactant in human amniotic fluid at term |
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