MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

• Published in: DNA repair Vol. 6; no. 8; pp. 1079 - 1099
• Main Authors: Kaina, Bernd, Christmann, Markus, Naumann, Steffen, Roos, Wynand P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2007
• Subjects: Alkylating agents; Alkylating Agents - toxicity; Alkylation; Alkyltransferase; Animals; Apoptosis - drug effects; Carcinogenicity; Carmustine; Chromosome Aberrations; DNA - chemistry; DNA - metabolism; DNA Damage; DNA Mismatch Repair; DNA Modification Methylases - genetics; DNA Modification Methylases - metabolism; DNA Repair; DNA Repair Enzymes - genetics; DNA Repair Enzymes - metabolism; Drug resistance; Gene Expression; Genotoxicity; Humans; In Vitro Techniques; MGMT; Models, Biological; Mutation; Necrosis; Neoplasms - etiology; Neoplasms - genetics; Neoplasms - metabolism; O-Methylguanine-DNA Methyltransferase - genetics; O-Methylguanine-DNA Methyltransferase - metabolism; Sister Chromatid Exchange; Temozolomide; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumor therapy; Alkyltransferase; MGMT; Carmustine; Alkylating agents; Genotoxicity; Temozolomide; Carcinogenicity; Drug resistance; Tumor therapy

O 6-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O 6-alkylguanine in DNA (collectively termed O 6-alkylating agents [O 6AA]). The defense is highly important, since O 6AA are common environmental carcinog...