Stimulation of Tyrosine Phosphorylation of a Brain Protein by Hibernation
Mammalian hibernation is a state of natural tolerance to severely decreased brain blood flow. As protein tyrosine phosphorylation is believed to be involved in the development of resistance to potentially cell-damaging insults, we used immunoblotting for the phosphotyrosine moiety to analyze extract...
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Published in | Journal of cerebral blood flow and metabolism Vol. 18; no. 9; pp. 1040 - 1045 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.09.1998
Lippincott Williams & Wilkins |
Subjects | |
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Abstract | Mammalian hibernation is a state of natural tolerance to severely decreased brain blood flow. As protein tyrosine phosphorylation is believed to be involved in the development of resistance to potentially cell-damaging insults, we used immunoblotting for the phosphotyrosine moiety to analyze extracts from various tissues of hibernating and nonhibernating ground squirrels. A single, hibernation-specific phosphoprotein was detected in the brain, but not in any other tissue tested. This protein, designated pp98 to reflect its apparent molecular weight, is distributed throughout the brain, and is associated with the cellular membrane fraction. The presence of the protein is tightly linked to the hibernation state; it is not present in contemporaneously assayed animals that are exposed to the same cold temperature as the hibernators, is present for the duration of a hibernation bout (tested from 1 to 14 days), and disappears within 1 hour of arousal from hibernation. The close association of pp98 with the hibernation state, its presence in cellular membranes, and the known properties of membrane phosphotyrosine proteins suggest that it may transduce a signal for adaptation to the limited availability of oxygen and glucose and low cellular temperature that characterizes hibernation in the ground squirrel. |
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AbstractList | Mammalian hibernation is a state of natural tolerance to severely decreased brain blood flow. As protein tyrosine phosphorylation is believed to be involved in the development of resistance to potentially cell-damaging insults, we used immunoblotting for the phosphotyrosine moiety to analyze extracts from various tissues of hibernating and nonhibernating ground squirrels. A single, hibernation-specific phosphoprotein was detected in the brain, but not in any other tissue tested. This protein, designated pp98 to reflect its apparent molecular weight, is distributed throughout the brain, and is associated with the cellular membrane fraction. The presence of the protein is tightly linked to the hibernation state; it is not present in contemporaneously assayed animals that are exposed to the same cold temperature as the hibernators, is present for the duration of a hibernation bout (tested from 1 to 14 days), and disappears within 1 hour of arousal from hibernation. The close association of pp98 with the hibernation state, its presence in cellular membranes, and the known properties of membrane phosphotyrosine proteins suggest that it may transduce a signal for adaptation to the limited availability of oxygen and glucose and low cellular temperature that characterizes hibernation in the ground squirrel. |
Author | Azzam, Rita Hallenbeck, John M. Jaffe, Howard Frerichs, Kai U. Brenner, Michael Ohtsuki, Toshiho Azzam, Nabil |
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Cites_doi | 10.1126/science.2417316 10.2165/00023210-199605060-00005 10.1152/ajpcell.1996.271.4.C1085 10.1073/pnas.76.9.4350 10.1126/science.7701324 10.1016/0896-6273(92)90177-F 10.1001/archneur.1990.00530110107027 10.1016/S0021-9258(19)75689-0 10.1046/j.1471-4159.1994.62041357.x 10.1007/978-3-642-73375-8_1 10.1073/pnas.89.15.7119 10.1038/316554a0 10.1097/00004647-199802000-00007 10.1001/archneur.1993.00540070080020 10.1016/0896-6273(93)90307-D 10.1038/369233a0 10.1126/science.1650499 10.1016/S0092-8674(05)80058-3 10.1126/science.1361685 10.1038/353558a0 10.1038/jcbfm.1994.26 10.1038/227680a0 10.1073/pnas.89.2.648 10.1126/science.1715095 10.1007/BF02515154 |
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Keywords | Ischemic tolerance Tyrosine kinase Membrane phosphotyrosine protein Ground squirrel Tyrosine Phosphorylation Ischemia Animal Hibernation Plasma membrane Immunoblotting assay Tolerance Exploration Physiology Localization |
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References | Storey, KB 1987; 262 Bading, H, Greenberg, ME 1991; 253 Dorman, PJ, Counsell, CE, Sandercock, AG 1996; 5 Merlio, J-P, Ernfors, P, Kokaia, Z, Middlemas, DS, Bengzon, J, Kokaia, JM, Smith, ML, Siesjö, BK, Hunter, T, Lindvall, O, Persson, H 1993; 10 Grant, SGN, O'Dell, TJ, Karl, KA, Stein, PL, Soriano, P, Kandel, ER 1992; 258 Frerichs, KU, Dienel, GA, Cruz, NF, Sokoloff, L, Hallenbeck, JM 1995; 268 Hallenbeck, JM, Frerichs, KU 1993; 50 Devary, Y, Gottlieb, RA, Smeal, T, Karin, M 1992; 71 Frerichs, KU, Kennedy, C, Sokoloff, L, Hallenbeck, JM 1994; 14 Hochachka, PW 1986; 231 Wang, LCH 1988 Ohtsuki, T, Matsumoto, M, Hayashi, Y, Yamamoto, K, Kitagawa, K, Ogawa, S, Yamamoto, S, Kamada, T 1995; 268 Pehowich D, J, Wang, LCH 1984; 154 Schlessinger, J, Ullrich, A 1992; 9 Brugge, JS, Cotton, PC, Queral, AE, Barrett, JN, Nonner, D, Keane, RW 1985; 316 D'Alecy, LG, Lundy, EF, Kluger, MJ, Harker, CT, LeMay, DR, Shlafer, M 1990; 96B Hu, B-R, Wieloch, T 1994; 62 O'Dell T, J, Kandel, ER, Grant, SGN 1991; 353 Towbin, H, Staehelin, T, Gordon, J 1979; 76 Laemmli, UK 1970; 227 Wang, YT, Salter, MW 1994; 369 Fisher, EH, Charbonneau, H, Tonks, NK 1991; 253 Frerichs, KU, Hallenbeck, JM 1997; 18 Ohtsuki, T, Matsumoto, M, Kitagawa, K, Mabuchi, T, Mandai, K, Matsushita, K, Kuwabara, K, Tagaya, M, Ogawa, S, Ueda, H, Kamada, T, Yanagihara, T 1996; 271 Yao, R, Cooper, GM 1995; 267 Hallenbeck, JM, Dutka, AJ 1990; 47 Srere, HK, Wang, LCH, Martin, SL 1992; 89 Lindvall, OP, Ernfors, J, Bengzon, Z, Kokaia, M-L, Smith, ML, Siesjö, BK, Persson, H 1992; 89 Frerichs, Dienel, Cruz, Sokoloff, Hallenbeck 1995; 268 Schlessinger, Ullrich 1992; 9 Ohtsuki, Matsumoto, Hayashi, Yamamoto, Kitagawa, Ogawa, Yamamoto, Kamada 1995; 268 Hallenbeck, Frerichs 1993; 50 Laemmli 1970; 227 Srere, Wang, Martin 1992; 89 Hochachka 1986; 231 O'Dell, Kandel, Grant 1991; 353 Brugge, Cotton, Queral, Barrett, Nonner, Keane 1985; 316 Grant, O'Dell, Karl, Stein, Soriano, Kandel 1992; 258 Fisher, Charbonneau, Tonks 1991; 253 Hallenbeck, Dutka 1990; 47 Wang, Salter 1994; 369 Frerichs, Hallenbeck 1997; 18 Dorman, Counsell, Sandercock 1996; 5 Devary, Gottlieb, Smeal, Karin 1992; 71 Frerichs, Kennedy, Sokoloff, Hallenbeck 1994; 14 Storey 1987; 262 Merlio, Ernfors, Kokaia, Middlemas, Bengzon, Kokaia, Smith, Siesjö, Hunter, Lindvall, Persson 1993; 10 Yao, Cooper 1995; 267 Lindvall, Ernfors, Bengzon, Kokaia, Smith, Siesjö, Persson 1992; 89 Ohtsuki, Matsumoto, Kitagawa, Mabuchi, Mandai, Matsushita, Kuwabara, Tagaya, Ogawa, Ueda, Kamada, Yanagihara 1996; 271 Bading, Greenberg 1991; 253 Hu, Wieloch 1994; 62 D'Alecy, Lundy, Kluger, Harker, LeMay, Shlafer 1990; 96B Towbin, Staehelin, Gordon 1979; 76 Pehowich, Wang 1984; 154 bibr4-00004647-199809000-00014 bibr14-00004647-199809000-00014 bibr27-00004647-199809000-00014 bibr26-00004647-199809000-00014 bibr5-00004647-199809000-00014 bibr13-00004647-199809000-00014 Frerichs KU (bibr8-00004647-199809000-00014) 1995; 268 bibr28-00004647-199809000-00014 bibr25-00004647-199809000-00014 bibr2-00004647-199809000-00014 bibr16-00004647-199809000-00014 bibr12-00004647-199809000-00014 bibr6-00004647-199809000-00014 Storey KB (bibr23-00004647-199809000-00014) 1987; 262 bibr15-00004647-199809000-00014 D'Alecy LG (bibr3-00004647-199809000-00014) 1990; 96 bibr21-00004647-199809000-00014 bibr9-00004647-199809000-00014 bibr20-00004647-199809000-00014 bibr7-00004647-199809000-00014 bibr11-00004647-199809000-00014 bibr1-00004647-199809000-00014 bibr17-00004647-199809000-00014 bibr24-00004647-199809000-00014 Ohtsuki T (bibr19-00004647-199809000-00014) 1995; 268 bibr18-00004647-199809000-00014 bibr22-00004647-199809000-00014 bibr10-00004647-199809000-00014 |
References_xml | – volume: 14 start-page: 193 year: 1994 end-page: 205 article-title: Local cerebral blood flow during hibernation, a model of natural tolerance to "cerebral ischemia." publication-title: J Cereb Blood Flow Metab contributor: fullname: Hallenbeck, JM – volume: 271 start-page: C1085 year: 1996 end-page: C1097 article-title: Delayed neuronal death in ischemic hippocampus involves stimulation of protein tyrosine phosphorylation publication-title: Am J Physiol contributor: fullname: Yanagihara, T – volume: 369 start-page: 233 year: 1994 end-page: 235 article-title: Regulation of NMDA receptors by tyrosine kinases and phosphatases publication-title: Nature Lond contributor: fullname: Salter, MW – volume: 10 start-page: 151 year: 1993 end-page: 164 article-title: Increased production of the TrkB protein tyrosine kinase receptor after brain insults publication-title: Neuron contributor: fullname: Persson, H – volume: 47 start-page: 1245 year: 1990 end-page: 1254 article-title: Background review and current concepts of reperfusion injury publication-title: Arch Neurol contributor: fullname: Dutka, AJ – volume: 96B start-page: 189 year: 1990 end-page: 193 article-title: β-hydroxybutyrate and response to hypoxia in the ground squirrel publication-title: Spermophilus tridecemlineatus. Comp Biochem Physiol contributor: fullname: Shlafer, M – volume: 253 start-page: 401 year: 1991 end-page: 406 article-title: Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes publication-title: Science Wash DC contributor: fullname: Tonks, NK – volume: 9 start-page: 383 year: 1992 end-page: 391 article-title: Growth factor signaling by receptor tyrosine kinases publication-title: Neuron contributor: fullname: Ullrich, A – volume: 62 start-page: 1357 year: 1994 end-page: 1367 article-title: Tyrosine phosphorylation and activation of mitogen activated protein kinase in the rat brain following transient cerebral ischemia publication-title: J Neurochem contributor: fullname: Wieloch, T – volume: 267 start-page: 2003 year: 1995 end-page: 2006 article-title: Requirement for phophatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor publication-title: Science Wash DC contributor: fullname: Cooper, GM – volume: 5 start-page: 457 year: 1996 end-page: 474 article-title: Recently developed neuroprotective therapies for acute stroke. A qualitative systematic review of clinical trials publication-title: CNS Drugs contributor: fullname: Sandercock, AG – volume: 18 start-page: 168 year: 1997 end-page: 175 article-title: Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia - an study in hippocampal slices publication-title: J Cereb Blood Flow Metab contributor: fullname: Hallenbeck, JM – volume: 50 start-page: 768 year: 1993 end-page: 770 article-title: Stroke therapy. It may be time for an integrated approach publication-title: Arch Neurol contributor: fullname: Frerichs, KU – volume: 258 start-page: 1903 year: 1992 end-page: 1910 article-title: Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice publication-title: Science Wash DC contributor: fullname: Kandel, ER – volume: 89 start-page: 648 year: 1992 end-page: 652 article-title: Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma publication-title: Proc Natl Acad Sci USA contributor: fullname: Persson, H – volume: 76 start-page: 4350 year: 1979 end-page: 4354 article-title: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications publication-title: Proc Natl Acad Sci USA contributor: fullname: Gordon, J – volume: 71 start-page: 1081 year: 1992 end-page: 1091 article-title: The mammalian ultraviolet response is triggered by activation of src tyrosine kinases publication-title: Cell contributor: fullname: Karin, M – start-page: 1 year: 1988 end-page: 45 article-title: Mammalian hibernation: an escape from the cold publication-title: Advances in Comparative and Environmental Physiology, Vol. 2 contributor: fullname: Wang, LCH – volume: 316 start-page: 554 year: 1985 end-page: 557 article-title: J Neurones express high levels of a structurally modified activated form of pp60c-src publication-title: Nature Lond contributor: fullname: Keane, RW – volume: 262 start-page: 1670 year: 1987 end-page: 1673 article-title: Regulation of liver metabolism by enzyme phosphorylation during hibernation publication-title: J Biol Chem contributor: fullname: Storey, KB – volume: 227 start-page: 680 year: 1970 end-page: 685 article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4 publication-title: Nature Lond contributor: fullname: Laemmli, UK – volume: 353 start-page: 558 year: 1991 end-page: 560 article-title: Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors publication-title: Nature Lond contributor: fullname: Grant, SGN – volume: 154 start-page: 495 year: 1984 end-page: 501 article-title: Seasonal changes in mitochondrial succinate dehydrogenase activity in a hibernator, Spermophilus richardsonii publication-title: J Comp Physiol B contributor: fullname: Wang, LCH – volume: 253 start-page: 912 year: 1991 end-page: 914 article-title: Stimulation of protein tyrosine phosphorylation by NMDA receptor activation publication-title: Science Wash DC contributor: fullname: Greenberg, ME – volume: 268 start-page: H1249 year: 1995 end-page: 1257 article-title: Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain publication-title: Am J Physiol contributor: fullname: Kamada, T – volume: 231 start-page: 234 year: 1986 end-page: 241 article-title: Defense strategies against hypoxia and hypothermia publication-title: Science Wash DC contributor: fullname: Hochachka, PW – volume: 268 start-page: R445 year: 1995 end-page: R453 article-title: Rate of glucose utilization in brain of active and hibernating ground squirrels publication-title: Am J Physiol contributor: fullname: Hallenbeck, JM – volume: 89 start-page: 7119 year: 1992 end-page: 7123 article-title: Central role for differential gene expression in mammalian hibernation publication-title: Proc Natl Acad Sci USA contributor: fullname: Martin, SL – volume: 154 start-page: 495 year: 1984 end-page: 501 article-title: Seasonal changes in mitochondrial succinate dehydrogenase activity in a hibernator, Spermophilus richardsonii publication-title: J Comp Physiol B contributor: fullname: Wang – volume: 353 start-page: 558 year: 1991 end-page: 560 article-title: Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors publication-title: Nature Lond contributor: fullname: Grant – volume: 262 start-page: 1670 year: 1987 end-page: 1673 article-title: Regulation of liver metabolism by enzyme phosphorylation during hibernation publication-title: J Biol Chem contributor: fullname: Storey – volume: 316 start-page: 554 year: 1985 end-page: 557 article-title: J Neurones express high levels of a structurally modified activated form of pp60c-src publication-title: Nature Lond contributor: fullname: Keane – volume: 18 start-page: 168 year: 1997 end-page: 175 article-title: Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and agly-cemia - an study in hippocampal slices publication-title: J Cereb Blood Flow Metab contributor: fullname: Hallenbeck – volume: 71 start-page: 1081 year: 1992 end-page: 1091 article-title: The mammalian ultraviolet response is triggered by activation of src tyrosine kinases publication-title: Cell contributor: fullname: Karin – volume: 231 start-page: 234 year: 1986 end-page: 241 article-title: Defense strategies against hypoxia and hypothermia publication-title: Science Wash DC contributor: fullname: Hochachka – volume: 9 start-page: 383 year: 1992 end-page: 391 article-title: Growth factor signaling by receptor tyrosine kinases publication-title: Neuron contributor: fullname: Ullrich – volume: 62 start-page: 1357 year: 1994 end-page: 1367 article-title: Tyrosine phosphorylation and activation of mitogen activated protein kinase in the rat brain following transient cerebral ischemia publication-title: J Neurochem contributor: fullname: Wieloch – volume: 258 start-page: 1903 year: 1992 end-page: 1910 article-title: Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice publication-title: Science Wash DC contributor: fullname: Kandel – volume: 47 start-page: 1245 year: 1990 end-page: 1254 article-title: Background review and current concepts of reperfusion injury publication-title: Arch Neurol contributor: fullname: Dutka – volume: 50 start-page: 768 year: 1993 end-page: 770 article-title: Stroke therapy. It may be time for an integrated approach publication-title: Arch Neurol contributor: fullname: Frerichs – volume: 253 start-page: 912 year: 1991 end-page: 914 article-title: Stimulation of protein tyrosine phosphorylation by NMDA receptor activation publication-title: Science Wash DC contributor: fullname: Greenberg – volume: 268 start-page: R445 year: 1995 end-page: R453 article-title: Rate of glucose utilization in brain of active and hibernating ground squirrels publication-title: Am J Physiol contributor: fullname: Hallenbeck – volume: 14 start-page: 193 year: 1994 end-page: 205 article-title: Local cerebral blood flow during hibernation, a model of natural tolerance to “cerebral ischemia.” publication-title: J Cereb Blood Flow Metab contributor: fullname: Hallenbeck – volume: 253 start-page: 401 year: 1991 end-page: 406 article-title: Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes publication-title: Science Wash DC contributor: fullname: Tonks – volume: 227 start-page: 680 year: 1970 end-page: 685 article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4 publication-title: Nature Lond contributor: fullname: Laemmli – volume: 369 start-page: 233 year: 1994 end-page: 235 article-title: Regulation of NMDA receptors by tyrosine kinases and phosphatases publication-title: Nature Lond contributor: fullname: Salter – volume: 76 start-page: 4350 year: 1979 end-page: 4354 article-title: Electrophoretic transfer of proteins from Polyacrylamide gels to nitrocellulose sheets: procedure and some applications publication-title: Proc Natl Acad Sci USA contributor: fullname: Gordon – volume: 5 start-page: 457 year: 1996 end-page: 474 article-title: Recently developed neuroprotective therapies for acute stroke. A qualitative systematic review of clinical trials publication-title: CNS Drugs contributor: fullname: Sandercock – volume: 10 start-page: 151 year: 1993 end-page: 164 article-title: Increased production of the TrkB protein tyrosine kinase receptor after brain insults publication-title: Neuron contributor: fullname: Persson – volume: 89 start-page: 648 year: 1992 end-page: 652 article-title: Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma publication-title: Proc Natl Acad Sci USA contributor: fullname: Persson – volume: 268 start-page: H1249 year: 1995 end-page: 1257 article-title: Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain publication-title: Am J Physiol contributor: fullname: Kamada – volume: 271 start-page: C1085 year: 1996 end-page: C1097 article-title: Delayed neuronal death in ischemic hippocampus involves stimulation of protein tyrosine phosphorylation publication-title: Am J Physiol contributor: fullname: Yanagihara – volume: 267 start-page: 2003 year: 1995 end-page: 2006 article-title: Requirement for phophatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor publication-title: Science Wash DC contributor: fullname: Cooper – volume: 89 start-page: 7119 year: 1992 end-page: 7123 article-title: Central role for differential gene expression in mammalian hibernation publication-title: Proc Natl Acad Sci USA contributor: fullname: Martin – volume: 96B start-page: 189 year: 1990 end-page: 193 article-title: β-hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecemlineatus publication-title: Comp Biochem Physiol contributor: fullname: Shlafer – ident: bibr13-00004647-199809000-00014 doi: 10.1126/science.2417316 – ident: bibr5-00004647-199809000-00014 doi: 10.2165/00023210-199605060-00005 – ident: bibr20-00004647-199809000-00014 doi: 10.1152/ajpcell.1996.271.4.C1085 – ident: bibr25-00004647-199809000-00014 doi: 10.1073/pnas.76.9.4350 – ident: bibr28-00004647-199809000-00014 doi: 10.1126/science.7701324 – volume: 268 start-page: H1249 year: 1995 ident: bibr19-00004647-199809000-00014 publication-title: Am J Physiol contributor: fullname: Ohtsuki T – ident: bibr24-00004647-199809000-00014 doi: 10.1016/0896-6273(92)90177-F – ident: bibr11-00004647-199809000-00014 doi: 10.1001/archneur.1990.00530110107027 – volume: 262 start-page: 1670 year: 1987 ident: bibr23-00004647-199809000-00014 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)75689-0 contributor: fullname: Storey KB – ident: bibr14-00004647-199809000-00014 doi: 10.1046/j.1471-4159.1994.62041357.x – ident: bibr26-00004647-199809000-00014 doi: 10.1007/978-3-642-73375-8_1 – ident: bibr22-00004647-199809000-00014 doi: 10.1073/pnas.89.15.7119 – ident: bibr2-00004647-199809000-00014 doi: 10.1038/316554a0 – ident: bibr9-00004647-199809000-00014 doi: 10.1097/00004647-199802000-00007 – ident: bibr12-00004647-199809000-00014 doi: 10.1001/archneur.1993.00540070080020 – ident: bibr17-00004647-199809000-00014 doi: 10.1016/0896-6273(93)90307-D – volume: 96 start-page: 189 year: 1990 ident: bibr3-00004647-199809000-00014 publication-title: Comp Biochem Physiol contributor: fullname: D'Alecy LG – ident: bibr27-00004647-199809000-00014 doi: 10.1038/369233a0 – ident: bibr6-00004647-199809000-00014 doi: 10.1126/science.1650499 – ident: bibr4-00004647-199809000-00014 doi: 10.1016/S0092-8674(05)80058-3 – ident: bibr10-00004647-199809000-00014 doi: 10.1126/science.1361685 – ident: bibr18-00004647-199809000-00014 doi: 10.1038/353558a0 – ident: bibr7-00004647-199809000-00014 doi: 10.1038/jcbfm.1994.26 – ident: bibr15-00004647-199809000-00014 doi: 10.1038/227680a0 – ident: bibr16-00004647-199809000-00014 doi: 10.1073/pnas.89.2.648 – volume: 268 start-page: R445 year: 1995 ident: bibr8-00004647-199809000-00014 publication-title: Am J Physiol contributor: fullname: Frerichs KU – ident: bibr1-00004647-199809000-00014 doi: 10.1126/science.1715095 – ident: bibr21-00004647-199809000-00014 doi: 10.1007/BF02515154 |
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SubjectTerms | Animals Biological and medical sciences Brain - metabolism Brain - physiology Cold Climate Fundamental and applied biological sciences. Psychology Hibernation - physiology Membrane Proteins - metabolism Nerve Tissue Proteins - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Sciuridae - physiology Signal Transduction - physiology Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
Title | Stimulation of Tyrosine Phosphorylation of a Brain Protein by Hibernation |
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