A Model of the Ventilatory Depressant Potency of Remifentanil in the Non–steady State

• Published in: Anesthesiology (Philadelphia) Vol. 99; no. 4; pp. 779 - 787
• Main Authors: Bouillon, Thomas, Bruhn, Joergen, Radu-Radulescu, Lucian, Andresen, Corina, Cohane, Carol, Shafer, Steven L.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Hagerstown, MD Lippincott 01.10.2003
• Subjects: Adult; Bayes Theorem; Biological and medical sciences; Confidence Intervals; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Female; Humans; Linear Models; Male; Medical sciences; Models, Biological; Pharmacology. Drug treatments; Piperidines - administration & dosage; Piperidines - blood; Piperidines - toxicity; Pulmonary Ventilation - drug effects; Pulmonary Ventilation - physiology; Remifentanil; Respiratory Insufficiency - blood; Respiratory Insufficiency - chemically induced; Toxicity: respiratory system, ent, stomatology; Human; Hypercapnia; Pharmacokinetic pharmacodynamic relationship; Healthy subject; Activity concentration relation; Respiratory disease; Toxicity; Opiates; Respiratory depression; Narcotic analgesic; Pharmacokinetics; Remifentanil
• ISSN: 0003-3022
• DOI: 10.1097/00000542-200310000-00007

The C50 of remifentanil for ventilatory depression has been previously determined using inspired carbon dioxide and stimulated ventilation, which may not describe the clinically relevant situation in which ventilatory depression occurs in the absence of inspired carbon dioxide. The authors applied i...