Targeting the DNA damage response for cancer therapy

• Published in: DNA repair Vol. 8; no. 9; pp. 1153 - 1165
• Main Authors: Powell, Simon N., Bindra, Ranjit S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.09.2009
• Subjects: BRCA1 Protein - metabolism; Checkpoints; Chromatin; Chromatin - metabolism; DNA Damage; DNA damage response; DNA Repair; Double-strand break repair; Homologous recombination; Humans; Hypoxia; Neoplasms - genetics; Neoplasms - therapy; Non-homologous end joining; S Phase; Single-strand break repair; Tumor micro-environment; Tumor suppressor gene; Chromatin; Single-strand break repair; Tumor micro-environment; DNA damage response; Homologous recombination; Non-homologous end joining; Checkpoints; Hypoxia; Double-strand break repair; Tumor suppressor gene

Human tumors frequently have defects in the maintenance of genomic integrity, which involve a loss of the appropriate response to DNA damage. These pathways of genome integrity include key proteins involved in cell cycle checkpoints, histone modifications, and DNA repair. In this review, we discuss...