Retroviral integration sites (RIS) mark cis -regulatory elements

• Published in: Critical reviews in oncology/hematology Vol. 71; no. 1; pp. 1 - 11
• Main Authors: Ng, Cherry Ee Lin, Ito, Yoshiaki, Osato, Motomi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.07.2009; Elsevier
• Subjects: Biological and medical sciences; Enhancer; Gene therapy; Genes, Viral; Hematologic and hematopoietic diseases; Hematology, Oncology and Palliative Medicine; Hox; Medical sciences; Pu.1; Regulatory Sequences, Nucleic Acid; Retroviral insertional mutagenesis; Retroviridae - genetics; Runx; Wnt-1; Hox; Enhancer; Retroviral insertional mutagenesis; Runx; Gene therapy; Wnt-1; Pu.1; Integration; Retroviridae; Virus; Cancerology; Transcription factor PU.1; Treatment; Insertion mutation; Regulatory sequence

Abstract Transcription in multicellular eukaryotic organisms involves an elaborate orchestration of the core promoter and cis -regulatory elements to drive spatiotemporally and quantitatively correct gene expression. Unlike promoters found immediately upstream of protein-coding genes, the positions...