Nano-encapsulation of furosemide microcrystals for controlled drug release

• Published in: Journal of controlled release Vol. 86; no. 1; pp. 59 - 68
• Main Authors: Ai, Hua, Jones, Steven A, de Villiers, Melgardt M, Lvov, Yuri M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 09.01.2003; Elsevier
• Subjects: Antihypertensive agents; Biological and medical sciences; Cardiovascular system; Controlled release; Crystallization; Delayed-Action Preparations - chemical synthesis; Delayed-Action Preparations - pharmacokinetics; Drug Compounding - methods; Furosemide; Furosemide - chemical synthesis; Furosemide - pharmacokinetics; General pharmacology; Medical sciences; Microspheres; Nano-encapsulation; Nanotechnology - methods; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Self-assembly; Self-assembly; Nano-encapsulation; Controlled release; Furosemide; Encapsulation; Sulfanilamide derivatives; Sulfonamide; Pharmaceutical technology; Controlled release: Furosemide; Slow release form; Drug carrier; In vitro; Adsorption; Gelatin; Dosage form; Styrenesulfonate polymer; Nao-encapsulation; Antihypertensive agent; Microparticle; Active ingredient; Polyion; Coating; Microcrystal; Release

Furosemide microcrystals were encapsulated with polyions and gelatin to control the release of the drug in aqueous solutions. Charged linear polyions and gelatin were alternatively deposited on 5-μm drug microcrystals through layer-by-layer (LbL) assembly. Sequential layers of poly(dimethyldiallyl a...