Lenalidomide Synergistically Enhances the Effect of Dendritic Cell Vaccination in a Model of Murine Multiple Myeloma

• Published in: Journal of immunotherapy (1997) Vol. 38; no. 8; p. 330
• Main Authors: Nguyen-Pham, Thanh-Nhan, Jung, Sung-Hoon, Vo, Manh-Cuong, Thanh-Tran, Huong-Thi, Lee, Youn-Kyung, Lee, Hyun-Ju, Choi, Nu-Ri, Hoang, My-Dung, Kim, Hyeoung-Joon, Lee, Je-Jung
• Format: Journal Article
• Language: English
• Published: United States 01.10.2015
• Subjects: Angiogenesis Inhibitors - therapeutic use; Animals; Cancer Vaccines - therapeutic use; Cell Line, Tumor; Combined Modality Therapy; Dendritic Cells - immunology; Female; Immunologic Factors - therapeutic use; Killer Cells, Natural - immunology; Mice, Inbred BALB C; Multiple Myeloma - drug therapy; Multiple Myeloma - therapy; Spleen - immunology; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Regulatory - immunology; Thalidomide - analogs & derivatives; Thalidomide - therapeutic use

We investigated the efficacy of lenalidomide (LEN) in combination with dendritic cell (DC) vaccination in the MOPC-315 murine myeloma model. After tumor growth, LEN was injected intraperitoneally for 4 consecutive days in combination with DC vaccination. The combination of LEN and vaccination effici...